Clinical Electrophysiology and Mathematical Modeling for Precision Diagnosis of Infertility DOI Creative Commons

Fernanda Carvalho Cavalari,

Paola Sulis Mendes,

Bruna Antunes Zaniboni

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 250 - 250

Published: Jan. 21, 2025

How can cellular electrophysiology measurements and mathematical modeling of ionic channels help to identify pivotal targets in disease-related cell signaling? The purpose this review is highlight the advantages disadvantages using both these complementary techniques determine molecular that may be structurally or functionally altered a specific disease. In addition, improve coordinated drug development, accelerate prediction new drugs, facilitate repositioning pharmacological agents. This focuses on data obtained from model approaches, including intracellular recording, patch clamp measurements, Hodgkin Huxley equation, as key precision methodologies. To end, seminiferous tubules, Sertoli line (TM4), and/or primary cultures cells were used explore role follicle-stimulating hormone (FSH), thyroid hormones, retinol, testosterone, 1,25(OH)2 vitamin D3 activation inhibition essential for male fertility. Based discussed data, precisely regulate their biological activity by coordinating channel according hormonal environment nutritional requirements required germ development.

Language: Английский

Clinical Electrophysiology and Mathematical Modeling for Precision Diagnosis of Infertility DOI Creative Commons

Fernanda Carvalho Cavalari,

Paola Sulis Mendes,

Bruna Antunes Zaniboni

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 250 - 250

Published: Jan. 21, 2025

How can cellular electrophysiology measurements and mathematical modeling of ionic channels help to identify pivotal targets in disease-related cell signaling? The purpose this review is highlight the advantages disadvantages using both these complementary techniques determine molecular that may be structurally or functionally altered a specific disease. In addition, improve coordinated drug development, accelerate prediction new drugs, facilitate repositioning pharmacological agents. This focuses on data obtained from model approaches, including intracellular recording, patch clamp measurements, Hodgkin Huxley equation, as key precision methodologies. To end, seminiferous tubules, Sertoli line (TM4), and/or primary cultures cells were used explore role follicle-stimulating hormone (FSH), thyroid hormones, retinol, testosterone, 1,25(OH)2 vitamin D3 activation inhibition essential for male fertility. Based discussed data, precisely regulate their biological activity by coordinating channel according hormonal environment nutritional requirements required germ development.

Language: Английский

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