Avaliação da mortalidade associada ao status tireoidiano em uma coorte de pessoas idosas eutireoidianas de ambulatório de geriatria em hospital universitário DOI Creative Commons
Aline Saraiva da Silva Correia, Natália Santana Paiva, Cláudia Medina Coeli

et al.

Revista Brasileira de Geriatria e Gerontologia, Journal Year: 2024, Volume and Issue: 27

Published: Jan. 1, 2024

Resumo Objetivo Avaliar associações entre a média da tireotropina (TSH) e tiroxina livre (T4L) mantida durante follow-up, mortalidade em pacientes idosos eutireoidianos definidos de acordo com faixa referência específica para idade (FR-e) do TSH. Método Coorte retrospectiva tipo análise sobrevivência incluindo acompanhados no ambulatório hospital universitário 2010 2013. Todos os participantes haviam sido avaliados quanto ao risco incapacidade funcional como critério admissão nesse ambulatório. As médias dos valores TSH T4L foram calculadas através das dosagens obtidas período acompanhamento. Cada FR-e foi dividida quatro partes iguais, considerando níveis mais baixos variável exposição (≤1,75 mUI/L <80 ≤2,0 ≥80 anos). Os dicotomizados duas categorias (< ≥1,37 ng/dL). O desfecho o tempo até morte. A regressão proporcional Cox empregada estimar hazard ratio (HR) intervalo confiança (IC) 95% Resultados 285 (73% mulheres, =80,4 anos) seguidos pela mediana 5,7 anos (IQR =3,7–6,4; máximo =7), sendo que 114 faleceram. Após modelo final ajustado, esteve associada limite inferior (HR=1,7; IC=1,1–2,7; p=0,016) elevado. (HR=2,0; IC=1,0–3,8; p=0,052). Conclusão Níveis médios altos associados morte coorte usando

Associations between indicators of lipid and glucose metabolism and hypothyroidism DOI Creative Commons
Xinyi Huang,

Huaiping Cheng,

Shuting Wang

et al.

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 18, 2025

Language: Английский

Citations

0
High Prevalence of CKM Syndrome in the US and Chinese Population with MASLD DOI
Dongmei Wang, Qingtao Yu,

Shze Jer HU

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Association between thyroid function and acute mountain sickness upon rapid ascent to 3650 m in euthyroid lowlanders in China DOI Creative Commons

Cencen Wu,

Yuanyuan Fan,

Jiageng Cai

et al.

Experimental Physiology, Journal Year: 2025, Volume and Issue: unknown

Published: May 5, 2025

Abstract Acute mountain sickness (AMS) is a major health issue for lowlanders when they ascend rapidly to altitudes above 2500 m. Thyroid hormones are essential adaptive responses the hypoxic environment of high altitude. However, there limited evidence regarding association between thyroid function and prevalence AMS. This study included 70 healthy euthyroid Chinese who ascended from Beijing (44 m sea level) Lhasa (3650 by aircraft (flight time, approximately 5 h). The dataset was divided into training set (80%) validation (20%) development prediction model. hormones, demographic data blood biochemical were measured in week before ascent. subjects an AMS group non‐AMS based on 2018 Lake Louise Mountain Sickness Scale score. hormone sensitivity indices compared groups. Multivariable logistic regression analysis revealed that higher baseline total triiodothyronine (TT3) level (odds ratio (OR) 2.474, 95% confidence interval (CI) 1.083–5.653) free triiodothyronine/free thyroxine (FT3/FT4) (OR 3.427; CI 1.266–9.280) independent risk factors receiver‐operating characteristic calibration curves showed model had good predictive ability consistency both sets. In China, with TT3 or FT3/FT4 more susceptible after exposure altitudes.

Language: Английский

Citations

0
Sex-specific associations between the developmental alterations in the pituitary-thyroid hormone axis and thyroid nodules in Chinese euthyroid adults: a community-based cross−sectional study DOI Creative Commons
Ying Li,

Genfeng Yu,

Nanfang Yao

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: May 10, 2024

Background Previous studies have revealed the sex-specific features of pituitary–thyroid hormone (TH) actions and prevalence thyroid nodules (TNs) in children adolescents. However, it was unclear adults. We aimed to investigate pituitary–TH women men at different ages, associations thyrotropin (TSH), THs, central sensitivity THs indices including feedback quantile-based index by FT4 (TFQI ) FT3(TFQI FT3 with TNs Chinese euthyroid Methods 8771 adults from communities China were involved. Demographic, behavioral, anthropometric data gathered through questionnaires. Ultrasound performed evaluate TNs. TSH levels measured. The multivariable logistic regression ordinal conducted. Results TFQI among both genders, except aged 43 59 years, where increased slightly. Additionally, there an age-related decline ages &lt; 50 53, respectively, but a marked increase after that. Lower significantly associated higher lower odds having fewer using multiple as base category (both P for trend 0.05). 0.05), men. Both women. relationships between or number not found. Conclusions trends TSH, , sex-dependent. negatively present results may lead better understanding development pituitary-TH axis formation

Language: Английский

Citations

1
Impaired Sensitivity to Thyroid Hormones is Associated with Central Obesity in Euthyroid Type 2 Diabetes Mellitus Patients with Overweight and Obesity DOI Creative Commons

Fei Chen,

Rujun Chen,

Jiangfeng Zhou

et al.

Diabetes Metabolic Syndrome and Obesity, Journal Year: 2024, Volume and Issue: Volume 17, P. 3379 - 3396

Published: Sept. 1, 2024

Thyroid hormone levels are associated with the distribution of body components in humans.

Language: Английский

Citations

1
Assessment of mortality associated with thyroid status in a cohort of euthyroid older adults from a geriatric outpatient clinic at a university hospital DOI Creative Commons
Aline Saraiva da Silva Correia, Natália Santana Paiva, Cláudia Medina Coeli

et al.

Revista Brasileira de Geriatria e Gerontologia, Journal Year: 2024, Volume and Issue: 27

Published: Jan. 1, 2024

Abstract Objective To assess the associations between mean thyrotropin (TSH) and free thyroxine (FT4), detected during follow-up, mortality in a group of older euthyroid patients according to age-specific reference range (as-RR) for TSH. Method Retrospective survival analysis cohort including elderly who were being monitored at outpatient clinic university hospital from 2010 2013. All participants had been assessed risk functional disability as criterion admission this clinic. Mean TSH FT4 values calculated using hormone dosages obtained follow-up period. Each as-RR was divided into four equal parts, considering lower levels main exposure variable (≤1.75 mlU/L <80, ≤2.0 ≥80 years). explored two categories (< e ≥1.37 ng/dL). The outcome time death. We used Cox proportional hazard regression estimate ratio (HR) 95% confidence interval (CI). Results 285 (73% females, age =80.4 years) followed by median 5.7 years (IQR =3.7–6.4; maximum =7), which 114 died. After adjusted final model, associated with lowest (HR=1.7; CI=1.1–2.7; p=0.016) upper (HR=2.0; CI=1.0–3.8; p=0.052). Conclusions Higher death adults an

Language: Английский

Citations

0
Avaliação da mortalidade associada ao status tireoidiano em uma coorte de pessoas idosas eutireoidianas de ambulatório de geriatria em hospital universitário DOI Creative Commons
Aline Saraiva da Silva Correia, Natália Santana Paiva, Cláudia Medina Coeli

et al.

Revista Brasileira de Geriatria e Gerontologia, Journal Year: 2024, Volume and Issue: 27

Published: Jan. 1, 2024

Resumo Objetivo Avaliar associações entre a média da tireotropina (TSH) e tiroxina livre (T4L) mantida durante follow-up, mortalidade em pacientes idosos eutireoidianos definidos de acordo com faixa referência específica para idade (FR-e) do TSH. Método Coorte retrospectiva tipo análise sobrevivência incluindo acompanhados no ambulatório hospital universitário 2010 2013. Todos os participantes haviam sido avaliados quanto ao risco incapacidade funcional como critério admissão nesse ambulatório. As médias dos valores TSH T4L foram calculadas através das dosagens obtidas período acompanhamento. Cada FR-e foi dividida quatro partes iguais, considerando níveis mais baixos variável exposição (≤1,75 mUI/L <80 ≤2,0 ≥80 anos). Os dicotomizados duas categorias (< ≥1,37 ng/dL). O desfecho o tempo até morte. A regressão proporcional Cox empregada estimar hazard ratio (HR) intervalo confiança (IC) 95% Resultados 285 (73% mulheres, =80,4 anos) seguidos pela mediana 5,7 anos (IQR =3,7–6,4; máximo =7), sendo que 114 faleceram. Após modelo final ajustado, esteve associada limite inferior (HR=1,7; IC=1,1–2,7; p=0,016) elevado. (HR=2,0; IC=1,0–3,8; p=0,052). Conclusão Níveis médios altos associados morte coorte usando

Citations

0