Per- and polyfluoroalkyl substances (PFAS) exposure is associated with radioiodine therapy resistance and dedifferentiation of differentiated thyroid cancer

Environmental Pollution, Journal Year: 2025, Volume and Issue: 367, P. 125629 - 125629

Published: Jan. 2, 2025

Language: Английский

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Detection of Polycyclic Aromatic Hydrocarbons in Water and Beverages Using Membrane-Assisted Solvent Extraction Coupled with Large Volume Injection GC-MS

Journal of Scientific Research, Journal Year: 2025, Volume and Issue: 17(1), P. 325 - 339

Published: Jan. 1, 2025

The present investigation aimed to enhance the identification of polycyclic aromatic hydrocarbons in water and beverages by employing large-volume injection (LVI) conjunction with membrane-assisted solvent extraction for gas chromatography-mass spectrometry analyses. High-purity solvents isotope-labeled standards were used calibrate create hydrocarbon (PAH) standards. Water samples from polluted rivers India commercially available collected preserved under controlled conditions. Microwave-assisted (MASE) was optimized adjusting temperature pH efficient extraction. extracts analyzed using (GC-MS) a system sensitive PAH detection. MASE-LVI-GC-MS efficiently determined 16 PAHs aqueous optimizing parameters like shaking speed, temperature, composition. Recovery percentages above 65 %, relative standard deviation 6 % guaranteed repeatability 18 during five consecutive extractions. It shown that great sensitivity achieved reaching detection limits within range nanograms per litre. In conclusion, combined GC-MS detects various beverage samples, achieving nanogram-per-liter sensitivity. offers uniform extraction, rapid analysis, reduced use across diverse matrices.

Language: Английский

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Contamination levels and distribution of persistent and non-persistent pollutants in paired hair, urine and serum samples from a Belgian non-occupationally exposed population

Journal of Toxicology and Environmental Health, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 16

Published: Jan. 16, 2025

Designing ideal human biomonitoring studies involves the selection of reliable markers exposure in adequate biological matrix. Besides conventional matrices such as blood or urine, hair has been increasingly investigated a promising noninvasive alternative. However, understanding pollutant distribution between differing compartments is essential for interpretation data collected. Therefore, contamination levels and some persistent (8 perfluoroalkyl substances – PFAS 6 polychlorobiphenyls PCBs) non-persistent pollutants (2 bisphenols 3 parabens) were paired serum samples, spot urine samples obtained from 30 Belgian non-occupationally exposed individuals. The measured close to those reported recent larger-scale studies. PFAS, PCB bisphenol distributions largely differed depending upon matrix within same chemical family congener. correlation agreement demonstrated that information provided comparable only highly chlorinated PCBs parabens, while classification was substantially different according thus remains complex might markedly bias results obtained, especially when assessing health risk related exposure.

Language: Английский

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Thyroid under Attack: The Adverse Impact of Plasticizers, Pesticides, and PFASs on Thyroid Function

Endocrines, Journal Year: 2024, Volume and Issue: 5(3), P. 430 - 453

Published: Sept. 19, 2024

Endocrine-disrupting chemicals (EDCs) are synthetic or natural compounds that interfere with the endocrine system, inducing harmful effects on organisms depending dose and period of exposure. Numerous studies have identified concerning amounts EDCs in environmental human samples. The thyroid gland is essential for hormone production controls several body functions. Several been classified as disruptors, impairing production, synthesis, metabolism, transport, and/or actions. Notably, disorders second most prevalent disease worldwide, incidence increasing significantly recent years. Some correlated this rise dysfunctions cancers increased exposure to EDCs. Although many linked dysfunction, review focuses deleterious plasticizers, organochlorine pesticides, per- poly-fluoroalkyl substances function. These contaminants commonly found food, water, everyday products. impact these controversial, numerous epidemiological, vivo, vitro indicated their Given critical role function growth, development, summarizes consequences disruptors health.

Language: Английский

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Redo Thyroidectomy: Updated Insights

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(18), P. 5347 - 5347

Published: Sept. 10, 2024

The risk of post-operatory hypothyroidism and hypocalcaemia, along with recurrent laryngeal nerve injury, is lower following a less-than-total thyroidectomy; however, previously unsuspected carcinoma or disease progression might be detected after initial surgery, hence indicating re-intervention as mandatory (so-called “redo” surgery) completion. This decision takes into consideration multidisciplinary approach, but the surgical technique actual approach entirely based on skills availability team according to standard protocols regarding personalised decision. We aimed introduce review most recently published data, respect redo thyroid surgery. For basis discussion, novel vignette point was introduced. narrative review. searched English-language papers key search terms in different combinations such “thyroid”, alternatively “thyroidectomy” “thyroid surgery”, across PubMed database. Inclusion criteria were original articles. timeframe publication between 1 January 2020 20 July 2024. Exclusion non-English papers, reviews, non-human studies, case reports series, exclusive data parathyroid cell line experiments. identified ten studies five-year recent window searches that showed heterogeneous spectrum complications applications surgeries interventions during removal (e.g., monitoring other types incision than cervicotomy, use fluorescence, bleeding risk, etc.). Most addressing perspectives focused robotic-assisted re-intervention, an expansion this kind expected. Further multifactorial models assessment prediction are necessary decide, assess, recommend adequate techniques.

Language: Английский

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Thyrotoxic Effects of Mixed Exposure to Perfluorinated Compounds: Integrating Population-Based, Toxicogenomic, Animal, and Cellular Evidence to Elucidate Molecular Mechanisms and Identify Potential Effector Targets

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 3, 2024

Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are emerging environmental endocrine disruptors that may adversely affect the human system, particularly thyroid gland, largest gland in body. An epidemiologic survey was conducted involving 318 community residents Shanghai, China, to assess PFAS exposure levels. The relationship between five function indicators analyzed using Bayesian Kernel Regression (BKMR) Weighted Quantile Sum (WQS). Ten effector genes related diseases were identified through Comparative Toxicogenomics Database (CTD) for bioinformatics analysis pathways involved explored mediation analysis. In vivo validation of these PCR, complemented by vitro cellular experiments transcriptome sequencing construction animal models simulate mixed general population. Mixed found impact health primarily lipid metabolism toxicogenomic studies resulted upregulation key associated with models. Our results demonstrate could expression modulation transcription factors, contributing development disease.

Language: Английский

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NARRATIVE OVERVIEW OF POSSIBLE PREVENTIVE MEASURES FOR DIFFERENTIATED THYROID CARCINOMAS.

Heliyon, Journal Year: 2024, Volume and Issue: 11(1), P. e41284 - e41284

Published: Dec. 18, 2024

Language: Английский

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