The microbiota: a key regulator of health, productivity, and reproductive success in mammals

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 5, 2024

The microbiota, intensely intertwined with mammalian physiology, significantly impacts health, productivity, and reproductive functions. normal microbiota interacts the host through following key mechanisms: acting as a protective barrier against pathogens, maintain mucosal integrity, assisting in nutrient metabolism, modulating of immune response. Therefore, supporting growth development host, providing protection pathogens toxic substances. influences brain behavior, demonstrated by comprehensive findings from controlled laboratory experiments human clinical studies. prospects suggested that gut microbiome influence neurodevelopmental processes, modulate stress responses, affect cognitive function gut-brain axis. Microbiota gastrointestinal tract farm animals break down ferment ingested feed into nutrients, utilize to produce meat milk. Among beneficial by-products short-chain fatty acids (SCFAs) are particularly noteworthy for their substantial role disease prevention promotion various productive aspects mammals. plays pivotal hormonal systems mammals, boosting performance both sexes fostering maternal-infant connection, thereby becoming crucial factor sustaining existence. is critical influencing success production traits A well-balanced improves absorption metabolic efficiency, leading better rates, increased milk production, enhanced overall health. Additionally, it regulates hormones like estrogen progesterone, which essential successful conception pregnancy. Understanding offers valuable insights optimizing breeding improving outcomes, contributing advancements agriculture veterinary medicine. This study emphasizes ecological roles highlighting contributions success. By integrating perspectives, demonstrates how microbial communities enhance function, regulation across species, offering benefit agricultural advancements.

Language: Английский

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Gut and reproductive tract microbiota: Insights into the pathogenesis of endometriosis (Review)

Biomedical Reports, Journal Year: 2023, Volume and Issue: 19(1)

Published: May 29, 2023

Endometriosis is characterized by the presence of endometrial-like tissue outside uterus and associated with an inflammatory immune response. The gut reproductive tract microbiota constitute a protective barrier against infection pathogens regulate functions. This review summarizes imbalance (i.e., dysbiosis) in endometriosis discusses how dysbiosis influences disease development. literature was searched for studies published from inception to March 2022 PubMed Google Scholar databases using combination specific terms. An altered microbiome has been reported numerous conditions, such as bowel disease, allergies, autoimmunity, cancer disorders (e.g., endometriosis). Furthermore, microbial hallmark decrease beneficial probiotics increase pathogenic microbes, which leads series estrobolomic metabolomic changes. Gut or mice, nonhuman primates, females endometriosis. Animal models demonstrated effects on lesion growth vice versa. system mediated microbiota-gut-reproductive axis triggers response that damages tissue, possibly However, whether alteration eubiosis (a balanced microbiota) cause result unclear. In conclusion, this provides overview relationship between endometriosis, focusing mechanisms may risk disease.

Language: Английский

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Microbiota Transplant and Gynecological Disorders: The Bridge between Present and Future Treatments

Microorganisms, Journal Year: 2023, Volume and Issue: 11(10), P. 2407 - 2407

Published: Sept. 27, 2023

Fecal microbiota transplantation (FMT) is a procedure that involves transferring fecal bacteria from healthy donor to patients’ intestines restore gut–immunity homeostasis. While FMT was primarily supposed treat gastrointestinal disorders such as inflammatory bowel disease and irritable syndrome—and especially Clostridium difficile infection (currently the only used clinical treatment)—recent research has suggested it may also become potential treatment for gynecological disorders, including endometriosis polycystic ovary syndrome (PCOS). On contrary, vaginal (VMT) newer less commonly than approach, its applications are still being explored. It direct grafting of entire women into tract patients easily rebuild local environment, restoring eubiosis relieving symptoms. Like FMT, VMT thought have in treating different microbiota-related conditions. In fact, many bacterial vaginosis vulvovaginal candidiasis, be caused by an imbalance microbiota. this review, we will summarize development, current challenges, future perspectives transplant, with aim exploring new strategies employment promising avenue broad range diseases.

Language: Английский

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Hotspots and research trends of gut microbiome in polycystic ovary syndrome: a bibliometric analysis (2012–2023)

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 8, 2025

Polycystic ovary syndrome (PCOS) is a common gynecological condition affecting individuals of reproductive age and linked to the gut microbiome. This study aimed identify hotspots research trends within domain microbiome in PCOS through bibliometric analysis. Utilizing techniques, we examined literature on from Web Science Core Collection spanning period 2012 2023. Analytical tools such as CiteSpace, VOSviewer, Bibliometric R packages were employed evaluate various metrics, including countries/regions, institutions, authors, co-cited authors' H-index, journals, co-references, keywords. A total 191 publications identified field PCOS, with an increase annual 2018 People's Republic China was most productive country, followed by United States America (USA), India. Shanghai Jiao Tong University, Fudan Beijing University Chinese Medicine top three institutions. Thackray VG prolific author, holding highest while Liu received number citations. The journal "Frontiers Endocrinology" published articles this domain. frequently reference authored Qi XY. analysis keyword burst detection "bile acids" (2021-2023) leading frontier keyword. Additionally, "gut dysbiosis," "phenotypes," "adolescents," "metabolomics," "metabolites," "fecal microbiota transplantation," "IL-22" have emerged primary keywords reflecting recent trends. explores how influences endocrine metabolic disorders related emphasizing its role development treatments targeting findings serve valuable resource for researchers, enabling them critical emerging areas investigation field.

Language: Английский

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Sex Hormones–Gut Microbiome Axis: An Update of What Is Known So Far

Current Opinion in Endocrine and Metabolic Research, Journal Year: 2025, Volume and Issue: unknown, P. 100571 - 100571

Published: Jan. 1, 2025

Language: Английский

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Complement Factor B Deficiency Is Dispensable for Female Fertility but Affects Microbiome Diversity and Complement Activity

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1393 - 1393

Published: Feb. 6, 2025

Complement factor B (CFB) is a crucial component for the activation of alternative pathway due to formation C3 convertase with C3b, which further produces C3b enhance overall complement activity. Although Cfb expressed not only in immune tissues, but also reproductive tract, physiological role reproduction remains unclear. In this study, we addressed issue by producing Cfb-knockout (KO) mice and analyzing their phenotypes. Sperm function, number ovulated oocytes, litter size were normal KO mice. contrast, diversity microbiomes gut vaginal tract significantly increased Some serine protease activity serum from was lower than that wild-type Since showed pathway, CFB found be essential pathway. Our results indicate although dispensable fertility development, it maintains suppressing activating

Language: Английский

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The Gut–Endometrium Axis: Exploring the Role of Microbiome in the Pathogenesis and Treatment of Endometrial Cancer—A Narrative Review

Cancers, Journal Year: 2025, Volume and Issue: 17(6), P. 1044 - 1044

Published: March 20, 2025

Background/Objectives: Endometrial cancer (EC) is a prevalent gynecological malignancy with an increasing incidence, particularly in developed countries. Recent research has demonstrated the significant involvement of gut and endometrial microbiomes pathogenesis progression EC. This review provides comprehensive overview existing knowledge on interactions between these microbial communities their influence Methodology: A literature was conducted using electronic databases including Google Scholar, Scopus, PUBMED, covering period from 2017 to 2024. The following keywords were used for search: (1) microbiome cancer, (2) endometrium (3) dysbiosis. selected articles chosen based inclusion exclusion criteria. Scale Assessment Narrative Review Articles (SANRA) evaluating assessing quality articles. Results: modulates systemic inflammation, immune responses, estrogen metabolism, all which are crucial factors EC development. Dysbiosis imbalance composition microbes that can cause chronic inflammation hormonal imbalances, contribute Similarly, microbiome, while less extensively studied, been implicated through mechanisms involving local modulation production harmful metabolites. Probiotics, prebiotics, fecal microbiota transplantation (FMT), personalized microbiota-based therapies be as clinical interventions management. emphasizes need further explore gut–endometrium axis its potential innovative therapeutic approaches. Understanding complex will become novel strategy prevent treat EC, ultimately enhancing patient outcomes.

Language: Английский

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Causal estimation of the relationship between reproductive performance and the fecal bacteriome in cattle

Animal Microbiome, Journal Year: 2025, Volume and Issue: 7(1)

Published: March 28, 2025

The gut bacteriome influences host metabolic and physiological functions. However, its relationship with reproductive performance remains unclear. In this study, we evaluated the between in beef cattle, such as Japanese black heifers. Artificial insemination (AI) was performed after 300 days of age, number AI required for pregnancy (AI number) evaluated. fecal at 150 age visualized using statistical structural equation modelling traits based on four types machine-learning algorithms (linear discriminant analysis, association random forest, XGBoost). heifers were classified into superior (1.04 ± 0.04 cycles, n = 26) inferior groups (3.87 0.27 23) according to median frequency AI. bacteria two examined compared differential which demonstrated that genera Rikenellaceae RC9 group Christensenellaceae R-7 increased group. Subsequently, correlation analysis interrelationships bacteriomes, patterns exhibited distinct characteristics. Therefore, employed identify distinctive factors groups. directed acyclic graphs carried out by DirectLiNGAM these extracted inferred family Erysipelotrichaceae Clostridium sensu stricto 1 Family XIII AD3011 strongly associated an increase number. Furthermore, a pathway involved creatinine degradation (PWY-4722) related bacteriomes and/or pathways not necessarily causal inference methodology applied investigate AI-dependent bacterial communities pregnant cattle. These findings suggest numbers, are crucial cattle production management, could be from nearly six months before AI, rather than immediately before. This study provides novel perspective environment role performance.

Language: Английский

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Association between the dietary index for gut microbiota and female infertility: the mediation effects of lymphocyte count and red blood cell folate

Journal of Reproductive Immunology, Journal Year: 2025, Volume and Issue: unknown, P. 104528 - 104528

Published: April 1, 2025

Language: Английский

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Emerging hallmarks of endometriosis metabolism: A promising target for the treatment of endometriosis

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Journal Year: 2022, Volume and Issue: 1870(1), P. 119381 - 119381

Published: Oct. 17, 2022

Language: Английский

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