Cells,
Journal Year:
2022,
Volume and Issue:
11(6), P. 997 - 997
Published: March 15, 2022
Much
is
known,
but
there
also
much
more
to
discover,
about
the
actions
that
thyroid
hormones
(TH)
exert
on
metabolism.
Indeed,
despite
fact
are
recognized
as
one
of
most
important
regulators
metabolic
rate,
remains
be
clarified
which
mechanisms
control/regulate
these
actions.
Given
their
energy
metabolism
and
mitochondria
main
cellular
site
where
transformations
take
place,
organelles
have
been
subject
extensive
investigations.
In
relatively
recent
times,
new
knowledge
concerning
both
(such
action,
existence
metabolically
active
TH
derivatives)
transduction
such
(among
others)
dynamics,
respiratory
chain
organization
in
supercomplexes
cristes
organization,
opened
pathways
investigation
field
control
action
at
level.
this
review,
we
highlight
approaches
complex
relationship
between
TH,
including
some
derivatives,
mitochondrial
chain.
Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: Jan. 13, 2022
Little
is
known
about
how
the
observed
fat-specific
pattern
of
3D-spatial
genome
organisation
established.
Here
we
report
that
adipocyte-specific
knockout
gene
encoding
nuclear
envelope
transmembrane
protein
Tmem120a
disrupts
fat
organisation,
thus
causing
a
lipodystrophy
syndrome.
deficiency
broadly
suppresses
lipid
metabolism
pathway
expression
and
induces
myogenic
by
repositioning
genes,
enhancers
miRNA-encoding
loci
between
periphery
interior.
Tmem120a-/-
mice,
particularly
females,
exhibit
syndrome
similar
to
human
familial
partial
FPLD2,
with
profound
insulin
resistance
metabolic
defects
manifest
upon
exposure
an
obesogenic
diet.
Interestingly,
occurred
in
cells
from
FPLD2
patients
harbour
LMNA
mutations.
Our
data
indicate
TMEM120A
functions
affect
many
adipose
its
loss
may
yield
adiposity
spectrum
disorders,
including
miRNA-based
mechanism
could
explain
muscle
hypertrophy
lipodystrophy.
Cells,
Journal Year:
2022,
Volume and Issue:
11(6), P. 991 - 991
Published: March 14, 2022
The
epicardial
adipose
tissue
(EAT)
is
the
visceral
fat
depot
of
heart
which
highly
plastic
and
in
direct
contact
with
myocardium
coronary
arteries.
Because
its
singular
proximity
myocardium,
adipokines
pro-inflammatory
molecules
secreted
by
this
may
directly
affect
metabolism
Its
accumulation,
measured
recent
new
non-invasive
imaging
modalities,
has
been
prospectively
associated
onset
progression
artery
disease
(CAD)
atrial
fibrillation
humans.
Recent
studies
have
shown
that
EAT
exhibits
beige
fat-like
features,
express
uncoupling
protein
1
(UCP-1)
at
both
mRNA
levels.
However,
thermogenic
potential
could
be
lost
age,
obesity
CAD.
Here
we
provide
an
overview
physiological
pathophysiological
relevance
further
discuss
whether
properties
serve
as
a
target
for
therapeutic
management
specific
focus
on
role
immune
cells
beiging
phenomenon.
Cells,
Journal Year:
2022,
Volume and Issue:
11(6), P. 997 - 997
Published: March 15, 2022
Much
is
known,
but
there
also
much
more
to
discover,
about
the
actions
that
thyroid
hormones
(TH)
exert
on
metabolism.
Indeed,
despite
fact
are
recognized
as
one
of
most
important
regulators
metabolic
rate,
remains
be
clarified
which
mechanisms
control/regulate
these
actions.
Given
their
energy
metabolism
and
mitochondria
main
cellular
site
where
transformations
take
place,
organelles
have
been
subject
extensive
investigations.
In
relatively
recent
times,
new
knowledge
concerning
both
(such
action,
existence
metabolically
active
TH
derivatives)
transduction
such
(among
others)
dynamics,
respiratory
chain
organization
in
supercomplexes
cristes
organization,
opened
pathways
investigation
field
control
action
at
level.
this
review,
we
highlight
approaches
complex
relationship
between
TH,
including
some
derivatives,
mitochondrial
chain.
