Exploring the mechanisms of chronic obstructive pulmonary disease and Crohn’s disease: a bioinformatics-based study DOI Creative Commons
Xinxin Zhang, Caiping Liu, L CAO

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 10, 2024

This study explored the comorbid mechanisms between Crohn's disease (CD) and chronic obstructive pulmonary (COPD) using bioinformatics analysis. From Gene Expression Omnibus (GEO) microarray dataset, 349 common differentially expressed genes (coDEGs) were identified, 8 shared hub found: CCL2, CXCL1, TLR2, ICAM1, PTPRC, ITGAX, PTGS2, MMP9, which vital for immune function regulation of inflammatory responses. In addition, also analyzed association coDEGs cell infiltration single-sample gene set enrichment algorithm (ssGSEA). Potential drugs related to these identified connectivity map (CMap). These findings provided new perspectives understanding interaction CD COPD.

Language: Английский

Exploring the mechanisms of chronic obstructive pulmonary disease and Crohn’s disease: a bioinformatics-based study DOI Creative Commons
Xinxin Zhang, Caiping Liu, L CAO

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 10, 2024

This study explored the comorbid mechanisms between Crohn's disease (CD) and chronic obstructive pulmonary (COPD) using bioinformatics analysis. From Gene Expression Omnibus (GEO) microarray dataset, 349 common differentially expressed genes (coDEGs) were identified, 8 shared hub found: CCL2, CXCL1, TLR2, ICAM1, PTPRC, ITGAX, PTGS2, MMP9, which vital for immune function regulation of inflammatory responses. In addition, also analyzed association coDEGs cell infiltration single-sample gene set enrichment algorithm (ssGSEA). Potential drugs related to these identified connectivity map (CMap). These findings provided new perspectives understanding interaction CD COPD.

Language: Английский

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