Hyperexcitation of the glutamatergic neurons in lateral hypothalamus induced by chronic pain contributes to depression-like behavior and learning and memory impairment in male mice DOI Creative Commons

Lianghui Meng,

Xuefeng Zheng,

Keman Xie

et al.

Neurobiology of Stress, Journal Year: 2024, Volume and Issue: 31, P. 100654 - 100654

Published: June 1, 2024

Chronic pain can induce mood disorders and cognitive dysfunction, such as anxiety, depression, learning memory impairment in humans. However, the specific neural network involved anxiety- depression-like behaviors caused by chronic remains poorly understood. In this study, behavioral test results showed that induced behaviors, male mice. c-Fos immunofluorescence fiber photometry recording glutamatergic neurons LH of mice with were selectively activated. Next, normal activated using optogenetic chemogenetic methods, which recapitulates some depressive-like well impairment, but not anxiety-like behavior. Finally, inhibition pain, effectively relieved impairment. Taken together, our findings suggest hyperexcitation is behavior pain.

Language: Английский

Copper-Induced Neurodegenerative Disorders and Therapeutic Potential of Curcumin-Loaded Nanoemulsion DOI Creative Commons

Govind Hake,

Akshada Mhaske, Rahul Shukla

et al.

Toxics, Journal Year: 2025, Volume and Issue: 13(2), P. 108 - 108

Published: Jan. 29, 2025

Copper accumulation in neurons induces oxidative stress, disrupts mitochondrial activity, and accelerates neuronal death, which is central to the pathophysiology of neurodegenerative diseases like Wilson disease. Standard treatments for copper toxicity, such as D-penicillamine, trientine, chloroquine, are frequently associated with severe side effects, creating a need safer therapeutic alternatives. To address this, we developed curcumin-loaded nanoemulsion (CUR-NE) using spontaneous emulsification technique, aimed at enhancing bioavailability efficacy curcumin. The optimized displayed particle size 76.42 nm, zeta potential −20.4 mV, high encapsulation efficiency 93.69%, stable uniform structure. vitro tests on SH-SY5Y neuroblastoma cells demonstrated that CUR-NE effectively protected against copper-induced promoting significant cellular uptake. Pharmacokinetic studies revealed exhibited longer half-life extended circulation time compared free Additionally, pharmacodynamic evaluations, including biochemical assays histopathological analysis, confirmed provided superior neuroprotection overload conditions. These results emphasize ability augment effects curcumin, presenting novel approach managing neurodegeneration. study highlights effectiveness nanoemulsion-based delivery platforms improving chelation neurological diseases.

Language: Английский

Citations

3
Theaflavins in Black Tea Mitigate Aging-Associated Cognitive Dysfunction via the Microbiota–Gut–Brain Axis DOI
Maiquan Li, Can Zhang,

Xing Xiao

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2023, Volume and Issue: 71(5), P. 2356 - 2369

Published: Jan. 31, 2023

Aging-associated cognitive dysfunction has a great influence on the lifespan and healthspan of elderly. Theaflavins (TFs), mixture ingredients formed from enzymatic oxidation catechins during manufacture tea, have positive contribution to qualities antiaging activities black tea. However, role TFs in mitigating aging-induced underlying mechanism remains largely unknown. Here, we find that effectively improve behavioral impairment via microbiota-gut-brain axis: maintain gut homeostasis by improving antioxidant ability, strengthening immune response, increasing expression tight junction proteins, restructuring microbiota, altering core microbiota metabolites, i.e., short-chain fatty acids essential amino (SCFAs AAs), upregulating brain neurotrophic factors. Removing with antibiotics partly abolishes neuroprotective effects TFs. Besides, correlation analysis indicates decrease such as Bacteroidetes Lachnospiraceae, increase metabolites' levels are positively correlated improvements. Taken together, our findings reveal potential aging-driven axis. The intake can be translated into novel dietary intervention approach against decline.

Language: Английский

Citations

29
Prolonged High-Fat Diet Consumption throughout Adulthood in Mice Induced Neurobehavioral Deterioration via Gut-Brain Axis DOI Open Access
Haicui Wu,

Wenxiu Zhang,

Mingyue Huang

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(2), P. 392 - 392

Published: Jan. 12, 2023

Neuropsychiatric disorders have been one of the worldwide health problems contributing to profound social and economic consequences. It is reported that consumption an excessive high-fat diet (HFD) in middle age could induce cognitive emotional dysfunctions, whereas mechanisms effects long-term HFD intake on brain not fully investigated. We propose a hypothesis prolonged throughout adulthood lead neurobehavioral deterioration via gut-brain axis. In this study, adult C57BL/6J mice consuming (24 weeks) exhibited more anxiety-like, depression-like, disruptive behaviors poorer performance learning memory than control fed with normal (ND). addition, homeostasis gut microbiota was impaired by consumption. Changes some flora, such as Prevotellaceae_NK3B31_group Ruminococcus, within communities, were correlated alterations. Furthermore, permeability increased after due decreased thickness mucus layer reduced expression tight junction proteins colon. The mRNA levels genes related synaptic-plasticity, neuronal development, microglia maturation, activation hippocampus prefrontal cortex HFD-fed lower those ND. Interestingly, transcripts proteins, ZO-1 Occludin involved blood-brain-barrier (BBB), both Those results indicated chronic resulted dysbiosis, which induced colon, turn leading local systemic inflammation. changes further contribute impairment functions alterations, including mood, sociability, memory. short, behavioral phenotypes neuropsychiatric observations study provide potential intervention strategies reduce risk targeting or manipulating microbiota.

Language: Английский

Citations

24
The chronic unpredictable mild stress (CUMS) Paradigm: Bridging the gap in depression research from bench to bedside DOI

Shweta Sharma,

Shivani Chawla,

Praveen Kumar

et al.

Brain Research, Journal Year: 2024, Volume and Issue: 1843, P. 149123 - 149123

Published: Nov. 1, 2024

Language: Английский

Citations

16
Small-molecule-induced epigenetic rejuvenation promotes SREBP condensation and overcomes barriers to CNS myelin regeneration DOI
Xuezhao Liu, Dazhuan Xin,

Xiaowen Zhong

et al.

Cell, Journal Year: 2024, Volume and Issue: 187(10), P. 2465 - 2484.e22

Published: May 1, 2024

Language: Английский

Citations

13
Exploring the anti-ferroptosis mechanism of Kai-Xin-San against Alzheimer's disease through integrating network pharmacology, bioinformatics, and experimental validation strategy in vivo and in vitro DOI
Chenchen Yan, S. Yang, Simai Shao

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 326, P. 117915 - 117915

Published: Feb. 13, 2024

Language: Английский

Citations

12
Kai-Xin-San ameliorates Alzheimer's disease-related neuropathology and cognitive impairment in APP/PS1 mice via the mitochondrial autophagy-NLRP3 inflammasome pathway DOI

Xiaoxiao Shan,

Wenwen Tao,

Junying Li

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 329, P. 118145 - 118145

Published: April 4, 2024

Language: Английский

Citations

12
Ginsenoside Ro ameliorates cognitive impairment and neuroinflammation in APP/PS1 mice via the IBA1/GFAP-MAPK signaling pathway DOI Creative Commons

Tianyao Li,

Jiaxin Chen,

Zhouyuan Xie

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 24, 2025

Ginseng, known as the "king of herbs," has long been used in traditional Chinese medicine due to its beneficial properties, including anti-aging, anti-inflammatory, and anti-apoptotic effects. Ginsenosides, active compounds ginseng, have shown promise treating neurodegenerative diseases such Alzheimer's disease (AD). This study investigates therapeutic potential Ginsenoside Ro underlying mechanisms AD treatment. In this study, male APP/PS1 transgenic mice were divided into five groups treated with or ginseng for one month. Cognitive function anxiety assessed through behavioral tests, open field test (OFT) Morris water maze (MWM). To evaluate Aβ deposition, neuronal apoptosis, neuroinflammation, MAPK pathway, various techniques employed: Thioflavin-T staining, Nissl immunofluorescence, Western blot, qRT-PCR analyses. significantly improved cognitive reduced mice. It also decreased deposition ameliorated apoptosis cerebral cortex. The treatment regulated expression pro-apoptotic proteins (Bax Caspase3) increased protein Bcl-2. Additionally, neuroinflammation by decreasing IBA1-positive microglia GFAP-positive astrocytes lowering pro-inflammatory cytokines while enhancing anti-inflammatory cytokine IL-10. Furthermore, phosphorylation levels p38 JNK pathway reduced, suggesting a key mechanism These findings provide strong evidence supporting agent disease. Its effects appear be mediated modulation IBA1/GFAP-MAPK which may offer new insights strategies.

Language: Английский

Citations

2
Treadmill Training-Induced Remyelination Rescues Cognitive Impairment After Acute Hypoxia DOI
Qing Zhang, Yangjie Xu, Haodong Luo

et al.

Neurochemical Research, Journal Year: 2025, Volume and Issue: 50(2)

Published: March 1, 2025

Language: Английский

Citations

1
Antibiotic-induced gut dysbiosis and cognitive, emotional, and behavioral changes in rodents: a systematic review and meta-analysis DOI Creative Commons

Shivdeep S. Hayer,

Soonjo Hwang, Jonathan B. Clayton

et al.

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: Sept. 1, 2023

There are previous epidemiological studies reporting associations between antibiotic use and psychiatric symptoms. Antibiotic-induced gut dysbiosis alteration of microbiota-gut-brain axis communication has been proposed to play a role in this association. In systematic review meta-analysis, we reviewed published articles that have presented results on changes cognition, emotion, behavior rodents (rats mice) after antibiotic-induced dysbiosis. We searched three databases—PubMed, Web Science, SCOPUS identify such using dedicated search strings extracted data from 48 articles. Increase anxiety depression-like was reported 32.7 40.7 percent the study-populations, respectively. Decrease sociability, social novelty preference, recognition memory spatial cognition found 18.1, 35.3, 26.1, 62.5 Only one bacterial taxon (increase Proteobacteria ) showed statistically significant association with behavioral anxiety). were no consistent findings statistical significance for potential biomarkers [Brain-derived neurotrophic factor (BDNF) expression hippocampus, serum corticosterone circulating IL-6 IL-1β levels]. Results meta-analysis revealed symptoms negative valence system (including depression) cognitive (decreased cognition) intake ( p < 0.05). However, between-study heterogeneity publication bias Risk evaluated be high majority studies. identified discussed several reasons could contribute examined. The provide promising evidence there is indeed an psychopathologies. inconsistencies implemented methodologies make generalizing these difficult. Gut microbiota depletion antibiotics may useful strategy evaluate if how microbes influence behavior, but used precludes any definitive interpretations translational impact clinical practice.

Language: Английский

Citations

17