The effect of curcumin and high-content eicosapentaenoic acid supplementations in type 2 diabetes mellitus patients: a double-blinded randomized clinical trial

Nutrition and Diabetes, Journal Year: 2024, Volume and Issue: 14(1)

Published: April 8, 2024

Abstract Background/objectives The present study investigated the effect of curcumin and eicosapentaenoic acid, as one main components omega-3 polyunsaturated fatty acids, on anthropometric, glucose homeostasis, gene expression markers cardio-metabolic risk in patients with type 2 diabetes mellitus. Subjects/methods This clinical trial was conducted at Endocrinology Clinic Imam Reza Hospital Tabriz. It aimed to determine impact Eicosapentaenoic Acid (EPA), Docosahexaenoic (DHA), supplements various health indicators Type Diabetes Mellitus (DM2) from 2021.02.01 2022.02.01. a randomized double-blinded over 12 weeks 100 participants randomly divided into four groups. Stratified randomization used assign two months supplementation based sex Body Mass Index (BMI). comprised groups: Group 1 received capsules 500 mg EPA 200 DHA, along nano-curcumin placebo; capsule 80 omega 3 Fatty Acids placebos; nano-curcumin; 4, control, placebos placebo. Results After twelve taking + Nano-curcumin supplements, experienced statistically significant reduction insulin levels their blood [MD: −1.44 (−2.70, −0.17)]. decrease significantly greater than changes observed placebo group −0.63 (−1.97, 0.69)]. also showed High-Sensitivity C-Reactive Protein (hs-CRP) compared ( p < 0.05). Additionally, had increase Total Antioxidant Capacity (TAC) 0.01). However, there were no differences Fasting Blood Sugar (FBS), Homeostatic Model Assessment Insulin Resistance (HOMA-IR) index, Quantitative Sensitivity Check (QUICKI), or Hemoglobin A1c (HbA1C) between groups (all > There −17.02 (−32.99, −1.05)], control −20.76 (−36.73, −4.79)] terms lowering serum cholesterol level. difference Triglycerides (TG) not = 0.093). decreases Low-Density Lipoprotein (LDL) −20.12 (−36.90, −3.34)] −20.79 (−37.57, −4.01)]. near-to-significant High-Density (HDL) 0.056). Finally, Vascular Endothelial Growth Factor (VEGF) −127.50 (−247.91, −7.09)], 126.25 (5.83, 246.66)], −122.76 (−243.17, −2.35)], Nano- 121.50 (1.09, 241.92)]. Conclusions findings suggest that 12-week may positively inflammation, oxidative stress, metabolic parameters diabetes. be potential intervention manage reduce complications associated further research is needed validate study’s establish long-term effects

Language: Английский

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Five Key Criteria for Identifying Optimal Therapeutic Targets in Protein‐Mediated Diseases

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(4)

Published: Jan. 1, 2025

Abstract Therapeutic trends involve designing ligands to target proteins in various diseases, but no parallel filters have been established prioritize pathological within pathogens for optimal inhibition. This study unveils that order a protein serve as an therapeutic intervention, it must exhibit five key attributes. It should druggable site with recognized cleft which ligand can be fitted high specificity. possess unique structure, distinct sequences having low similarity other non‐targeted proteins. dispensable the pathogenesis of disease, and case microbial infection, crucial survival infectious organisms. available crystallized 3D structure enable high‐throughput screening candidate ligands. occupy accessible localization provide easy route reach its less effort. The justifies rules essential considering ideal any protein‐mediated dysfunction. When these targeting are found protein, eradicating intended ailment primarily enhanced time, money,

Language: Английский

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Potential of SIRT6 modulators in targeting molecular pathways involved in cardiovascular diseases and their treatment-A comprehensive review

Biochemical Pharmacology, Journal Year: 2025, Volume and Issue: 233, P. 116787 - 116787

Published: Jan. 31, 2025

Language: Английский

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The structure of a NEMO construct engineered for screening reveals novel determinants of inhibition

Structure, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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Potencial Terapêutico da Vortioxetina: Respostas Cardíacas ao Estresse Crônico Moderado Imprevisível em um Modelo de Rato

Arquivos Brasileiros de Cardiologia, Journal Year: 2025, Volume and Issue: 122(2)

Published: Jan. 1, 2025

Stress arises in response to threats or challenges, affecting both physical and mental health. While its harmful effects on the heart are widely recognized, cellular-level investigations remain limited. Antidepressants, including vortioxetine (VOR), known impact cardiovascular system. VOR, used treat major depressive disorder, is considered a promising option for patients with disease due anti-inflammatory antioxidant properties, which may reduce cardiac damage. This study aimed assess of chronic unpredictable mild stress (CUMS) rat hearts evaluate VOR's potential protective against stress-induced Twenty-eight male Wistar Albino rats were divided into four groups. The CUMS group experienced random daily 6 weeks, while CUMS+VOR received VOR treatment alongside stress. control groups not exposed Heart samples examined histopathologically immunohistochemically. showed increased hyperemia, hemorrhage, edema, vacuolar degeneration, mononuclear cell infiltrations, reduced troponin IL-10 caspase-3 NF-κB expressions compared (p≤0.001). improved these findings, normalizing histopathological immunohistochemical results. caused significant damage rats, by alleviating pathological changes.

Language: Английский

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Sex Differences in Circulating Inflammatory, Immune, and Tissue Growth Markers Associated with Fabry Disease-Related Cardiomyopathy

Cells, Journal Year: 2025, Volume and Issue: 14(5), P. 322 - 322

Published: Feb. 20, 2025

Fabry disease (FD) is a lysosomal disorder due to alpha-galactosidase-A enzyme deficiency, accumulation of globotriaosylceramide (Gb3) and globotriaosylsphingosine (lyso-Gb3) which lead proinflammatory effects. Males develop progressive hypertrophic cardiomyopathy (HCM) followed by fibrosis; females nonconcentric hypertrophy and/or early fibrosis. The inflammatory response Gb3/lyso-Gb-3 one the suggested pathogenic mechanisms in FD when secretion transforming growth factors with infiltration lymphocytes macrophages into tissue promotes cardiofibrosis. This study aims evaluate inflammation-driving cytokines cardio-hypertrophic remodeling biomarkers contributing sex-specific HCM progression. Biomarkers were studied 20 healthy subjects 45 patients. IL-2, IL-10, TNF-α, IFN-γ elevated all patients, while IL-1α, MCP-1, TNFR2 showed differences. increased associated NF-kB pathway males HCM, revealing correlation between IFN-γ, VEGF, GM-CSF, IL-2. In female impaired TNFα/TNFR2/TGFβ cluster correlations IL-1α was observed. activation indicates significant inflammation during males. signaling may explain fibrosis cardiomyopathy. Sex-specific responses influence severity progression HCM.

Language: Английский

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Comparative chemical profiling, antimicrobial activity of Cyclospermum leptophyllum (Pers.) Sprague ex Britton and P. Wilson essential oil and evaluation of their integrative network pharmacology

Natural Product Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 6

Published: March 31, 2025

Cyclospermum leptophyllum is an annual herb of the Apiaceae family. This study aims to investigate chemical compositions C. aerial, fruits, leaves, and stem parts evaluate their potential anti-microbial activity. For identification quantification essential oil (EO) constituents gas chromatography-mass spectrometry chromatography-flame ionisation detector techniques was used. The hydrodistillation stem, fruit part resulted in (0.45-0.65)% v/w EOs yield. Altogether, twenty compounds were identified from all samples representing (99.45%-99.67%) total composition. composition dominated by oxygenated monoterpenes (53.91%-89.77%) with thymohydroquinone dimethyl ether (37.91%-67.94%) present major amounts four parts. Further, antimicrobial activity evaluated against six strains bacteria two fungal strains. To analyse therapeutic effect EO network pharmacological approach applied.

Language: Английский

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Aspalathin-Rich Unfermented Aspalathus linearsis Extract Mitigates Vascular Endothelial Inflammation by Inhibiting the TNF-α/Hexokinase 2/NF-κB Signaling Pathway

Journal of Agriculture and Food Research, Journal Year: 2025, Volume and Issue: unknown, P. 101882 - 101882

Published: April 1, 2025

Language: Английский

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Cardiometabolic implications of adipose tissue aging

Obesity Reviews, Journal Year: 2024, Volume and Issue: 25(11)

Published: July 30, 2024

Adipose tissue is a large endocrine organ that serves numerous physiological functions. As we age, adipose remodels and can develop functional changes alters its phenotype, potentially contributing to metabolic cardiovascular disorders. Aging characterized by regional redistribution of fat, accumulation senescent cells, fibrosis, decline in adipocyte differentiation capacities, which collectively impact function whole body health. A notable transformation involves increased intra-abdominal visceral ectopic fat around internal organs such as the heart, blood vessels, liver, kidneys alter their Other associated with aging include alterations adipokine secretion size numbers. adipocytes play role mediating chronic inflammation, dysfunction, insulin resistance. Visceral tissue, increases volume aging, particular angiogenic microvascular abnormalities, mediators released may have adverse consequences systemically multiple target organs, including system. Understanding mechanisms underlying on health are important for developing interventions treatments promote healthy reduce cardiometabolic disease risk.

Language: Английский

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Investigating the NF-κB Signaling Pathway in Heart Failure: Exploring Potential Therapeutic Approaches

Heliyon, Journal Year: 2024, Volume and Issue: 10(23), P. e40812 - e40812

Published: Nov. 30, 2024

Language: Английский

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