Neopterin production in relation to COVID-19 in the Haut-Ogooué Province, Gabon DOI Creative Commons
Serge Ely Dibakou,

Chérone Nancy Mbani-Mpega-Ntigui,

Sandrine Lydie Oyegue-Liabagui

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 24, 2023

Abstract Background At the beginning of COVID-19 pandemic, immunological aspects SARS-CoV-2 were not at forefront research in sub-Saharan Africa. In this context, study aimed to investigate association between plasma neopterin concentrations and infection, with a focus on changes over time age-related immune response. Methods We included cohort 325 individuals, consisting 124 201 healthy controls June August 2020. Whole blood associated symptoms comorbidities collected from all individuals enrollment longitudinally 28 days. Concentrations measured using commercial competitive ELISA (Neopterin ELISA, IBL International GmbH, Germany). Results found elevated concentration (mean ± SD: 50.0 15) compared 34.0 1.6), indicating active responses cases. Longitudinal analysis showed decline levels time, initial sampling (first day) it was 42.00 12.00 nmol/l, measure day 10 30.00 02.00 nmol/l 14 25.00 05.00 nmol/l. Moreover, significant positive correlation age. This increase may indicate more pronounced response older individuals. Conclusion provides evidence an indicates as marker capable diagnosing age related young one. Our suggests also that serve valuable biomarker for assessing monitoring disease progression during outbreak.

Language: Английский

Evaluation of serum neopterin levels in severe COVID-19 patients: An observational study DOI Creative Commons
Sinem GÜRCÜ, Zeynep Irmak Kaya, Ali Uncu

et al.

Medicine, Journal Year: 2024, Volume and Issue: 103(30), P. e38996 - e38996

Published: July 26, 2024

In patients with coronavirus disease (COVID-19), a massive inflammatory response is significant cause of morbidity and mortality. Inflammatory markers are prognostic indicators severity the ultimate clinical outcome. Several studies have demonstrated correlation between serum levels neopterin, which can be an immune system marker, severity, poor outcomes in COVID-19 patients. Our study aimed to determine diagnostic significance neopterin conjunction routinely measured severe COVID-19. Serum C-reactive protein (CRP), albumin levels, complete blood count were determined 39 30 healthy individuals. Demographic characteristics, other laboratory data compared volunteers statistically analyzed. High observed volunteers. Furthermore, decreased, while CRP increased patients, significantly. Also, positive correlations shown negative levels. Systemic inflammation markers, CRP/albumin ratio, neutrophil/lymphocyte platelet/lymphocyte ratio significantly higher, lymphocyte/monocyte was also lower than However, not linked or ratio. On hand, they negatively findings highlight association high Neopterin correlated traditional biomarkers may indicate general activation

Language: Английский

Citations

0
Neopterin production in relation to COVID-19 in the Haut-Ogooué Province, Gabon DOI Creative Commons
Serge Ely Dibakou,

Chérone Nancy Mbani-Mpega-Ntigui,

Sandrine Lydie Oyegue-Liabagui

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 24, 2023

Abstract Background At the beginning of COVID-19 pandemic, immunological aspects SARS-CoV-2 were not at forefront research in sub-Saharan Africa. In this context, study aimed to investigate association between plasma neopterin concentrations and infection, with a focus on changes over time age-related immune response. Methods We included cohort 325 individuals, consisting 124 201 healthy controls June August 2020. Whole blood associated symptoms comorbidities collected from all individuals enrollment longitudinally 28 days. Concentrations measured using commercial competitive ELISA (Neopterin ELISA, IBL International GmbH, Germany). Results found elevated concentration (mean ± SD: 50.0 15) compared 34.0 1.6), indicating active responses cases. Longitudinal analysis showed decline levels time, initial sampling (first day) it was 42.00 12.00 nmol/l, measure day 10 30.00 02.00 nmol/l 14 25.00 05.00 nmol/l. Moreover, significant positive correlation age. This increase may indicate more pronounced response older individuals. Conclusion provides evidence an indicates as marker capable diagnosing age related young one. Our suggests also that serve valuable biomarker for assessing monitoring disease progression during outbreak.

Language: Английский

Citations

0