Alcoholic Cardiomyopathy in Patients With Advanced Alcoholic Liver Disease: Single-Center Experience and Review of Literature DOI

Roshan Dhand,

Kenji Okumura, Kevin Wolfe

et al.

Cardiology in Review, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

The impact of excessive alcohol on human health is associated with a lifetime cumulative use and further affected by various factors such as age, gender, nutritional status, concurrent cigarette smoking or drug use, diabetes, obesity, other cardiovascular diseases, socio-economic status. Alcohol cardiomyopathy (ACM) type acquired dilated cardiomyopathy, which long-term heavy consumption historical rates varying from 3.8% to 47 % among patients heart failure. Data regarding the prevalence ACM in alcoholic liver disease limited. Among 483 advanced who underwent transplant evaluation at single center during 2016–2021, based screening transthoracic echocardiogram clear definition, none (0%) had (range ejection fraction: 55–80%), 7% left ventricular dilation (mild dilation: 82%), 12.4% diastolic dysfunction. We also review data known risk factors, natural progression, treatment ACM, explore evidence concurrence alcohol-associated organs pancreas. In persons consumption, abstinence moderating its has been shown help decrease progression failure, arrythmias, hypertension well Focus identification both genetic markers modifiable organ injuries conjunction public policies for safe needed mitigate disorder.

Language: Английский

Once-Weekly Semaglutide in Adults With Alcohol Use Disorder DOI
Christian S. Hendershot, Michael P. Bremmer, Michael B. Paladino

et al.

JAMA Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Importance Preclinical, observational, and pharmacoepidemiology evidence indicates that glucagon-like peptide 1 receptor agonists (GLP-1RAs) may reduce alcohol intake. Randomized trials are needed to determine the clinical significance of these findings. Objective To evaluate effects once-weekly subcutaneous semaglutide on consumption craving in adults with use disorder (AUD). Design, Setting, Participants This was a phase 2, double-blind, randomized, parallel-arm trial involving 9 weeks outpatient treatment. Enrollment occurred at an academic medical center US from September 2022 February 2024. Of 504 potential participants assessed, 48 non–treatment-seeking AUD were randomized. Intervention received (0.25 mg/week for 4 weeks, 0.5 1.0 mg week) or placebo weekly clinic visits. Main Outcomes Measures The primary outcome laboratory self-administration, measured pretreatment posttreatment (0.5 mg/week). Secondary exploratory outcomes, including prospective changes craving, assessed Results Forty-eight (34 [71%] female; mean [SD] age, 39.9 [10.6] years) Low-dose reduced amount consumed during self-administration task, medium large effect sizes grams (β, −0.48; 95% CI, −0.85 −0.11; P = .01) peak breath concentration −0.46; −0.87 −0.06; .03). Semaglutide treatment did not affect average drinks per calendar day number drinking days, but significantly −0.41; −0.73 −0.09; .04) −0.39; .01), also predicting greater reductions heavy over time relative 0.84; 0.71 0.99; .04). A significant treatment-by-time interaction indicated predicted cigarettes subsample individuals current cigarette −0.10; −0.16 −0.03; .005). Conclusions Relevance These findings provide initial low-dose can some justifying larger GLP-1RAs disorder. Trial Registration ClinicalTrials.gov Identifier: NCT05520775

Language: Английский

Citations

3
The association between glucose‐dependent insulinotropic polypeptide and/or glucagon‐like peptide‐1 receptor agonist prescriptions and substance‐related outcomes in patients with opioid and alcohol use disorders: A real‐world data analysis DOI Creative Commons
Fares Qeadan,

Ashlie McCunn,

Benjamin Tingey

et al.

Addiction, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

Abstract Aims This study aimed to estimate the strength of association between prescriptions glucose‐dependent insulinotropic polypeptide (GIP) and/or glucagon‐like peptide‐1 receptor agonists (GLP‐1 RA) and incidence opioid overdose alcohol intoxication in patients with use disorder (OUD) (AUD), respectively. also compare GIP/GLP‐1 RA substance use‐outcome among comorbid type 2 diabetes obesity. Design A retrospective cohort analyzing de‐identified electronic health record data from Oracle Cerner Real‐World Data. Setting About 136 United States America systems, covering over 100 million patients, spanning January 2014 September 2022. Participants The included 503 747 a history OUD 817 309 AUD, aged 18 years or older. Measurements exposure indicated presence (one more) absence prescriptions. outcomes were rates AUD cohort. Potential confounders comorbidities demographic factors. Findings Patients demonstrated statistically significantly lower [adjusted rate ratio (aIRR) patients: 0.60; 95% confidence interval (CI) = 0.43–0.83] (aIRR 0.50; CI 0.40–0.63) compared those without such When stratified by conditions, incident remained similarly protective for prescribed AUD. Conclusions Prescriptions appear be associated disorder. effects are consistent across various subgroups, including

Language: Английский

Citations

10
Trends in alcohol-specific deaths in England, 2001–22: an observational study DOI Creative Commons
Melissa Oldham, Sarah E. Jackson, Jamie Brown

et al.

The Lancet Public Health, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

1
Sex and sobriety: Human brain structure and function in AUD abstinence DOI
Nicole L. Zabik, Jennifer Urbano Blackford

Alcohol, Journal Year: 2024, Volume and Issue: 121, P. 33 - 44

Published: July 27, 2024

Language: Английский

Citations

4
High prevalence of alcohol use disorders in 454 young adult offspring from the San Diego prospective study DOI Open Access
Marc A. Schuckit,

Tom L. Smith,

Lee Anne Mendoza

et al.

Alcohol Clinical and Experimental Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Abstract Background Preliminary evaluations of 212 drinking offspring from the San Diego Prospective Study (SDPD) indicated that over 50% developed alcohol use disorder (AUD) by their mid‐20s. The present analysis evaluated if those findings remained robust when group increased to 454 individuals, a sample size facilitated search for potential contributors high AUD prevalence. Methods Semistructured interviews were used evaluate lifetime diagnoses in 224 daughters and 230 sons SDPS ( N = 454) mean age 26. Analyses compared participants with without regarding demography, use, personality, psychiatric diagnoses. Characteristics associated entered together backward elimination regression analysis, results structural equation model (SEM) mediation risks problems. Results Lifetime was documented 61% 41% daughters. Offspring reported averages 13 maximum five usual drinks per occasion endorsed an average 4 DSM criteria. Even after considering personality characteristics, family histories, personal significant contributions limited lower levels response alcohol, higher positive expectancies, cope. Key elements hypothesized SEM supported, between low number problems cope, peer heavier drinking. Conclusion support prior rates demonstrate intake data also impact on development through several characteristics proposed work other populations.

Language: Английский

Citations

0
Estimating mortality attributable to alcohol or tobacco – a cohort study from Germany DOI Creative Commons
Ulrich John, Hans‐Jürgen Rumpf, Monika Hanke

et al.

Substance Abuse Treatment Prevention and Policy, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 22, 2025

Abstract Background Little is known about mortality from four disorder combinations: fully attributable to alcohol or tobacco, partly both and tobacco only, only. Aim To analyze whether residents who had disclosed risky drinking daily smoking a shorter time death than non-risky drinkers never smokers twenty years later according the combinations. Methods A random adult general population sample (4,075 study participants) of northern German area been interviewed in 1996–1997. Vital status certificate data were gathered 2017–2018. The analysis included estimates alcohol- tobacco-attributable using all conditions given alternatively underlying cause Results Among 573 deaths, 71.9–94.1% any depending on estimate. Risky consumption at baseline related disorders Deaths with an (subhazard ratio 1.57; 95% confidence interval 1.25–1.98) 1.85; 1.42–2.41). Conclusion First, more 70% deceased persons one disorders. This finding suggests that total seems be suitable outcome if potential effects are estimated. Second, relations speak favor validity certificates considering deaths

Language: Английский

Citations

0
Association of Medicare Advantage vs Traditional Medicare with Clinical Outcomes Among Patients Hospitalized for Substance Use Disorders DOI

Eden Y. Bernstein,

Christina X. Fu,

John Z. Ayanian

et al.

Journal of General Internal Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Language: Английский

Citations

0
Effects of direct-to-consumer alcohol home delivery policies on alcohol-related online searches in the United States from 2019 to 2023: A Google trends study DOI Creative Commons
McKenna Roudebush, Melissa J. Cox,

Kurt M. Ribisl

et al.

Preventive Medicine Reports, Journal Year: 2025, Volume and Issue: 51, P. 103005 - 103005

Published: Feb. 15, 2025

Language: Английский

Citations

0
Exploring the impact of graded alcohol use on atherogenic lipid profiles among Latinos with underlying chronic liver disease DOI
Shyam Patel,

Laura N. Bull,

Kian Salimi

et al.

Alcohol Clinical and Experimental Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

Abstract Background Alcohol use and hepatitis C virus (HCV) often coexist are associated with cardiovascular disease. One of the underlying drivers is dyslipidemia. We assessed lipid lipoprotein levels relationship between alcohol atherogenic profiles, specifically small dense low‐density cholesterol (sdLDL‐C), in Latinos without HCV. Methods From June 1, 2002, to January 2016, 150 Latino adults underwent demographic, clinical, metabolic, lipid/lipoprotein, genetic evaluations. Linear regression (adjusted for age, sex, recent use) factors sdLDL‐C. Results Participant characteristics were as follows: median age 44 years, 64% male, 39% HCV+, last 12 months was 19% heavy 47% moderate. Ancestries 52% European, 40% Native American (NA), 4.3% African. 29% had non‐CC PNPLA3 , 89% TM6SF2 73% IL‐28b genotypes. High‐density (HDL) cholesterol, HDL‐3, apolipoprotein A‐1, lipoprotein‐associated phospholipase A2 differed by groups ( p < 0.05). On multivariable analysis, female sex (est. –6.08, 0.001), HCV+ status –8.49, (vs. none) –4.32, = 0.03) lower, while NA ancestry 0.92; 0.01) adipose tissue insulin resistance 3.30, 0.001) higher sdLDL‐C levels. The positive association dampened presence a IL28b genotype (interaction est. −1.95, 0.01). Conclusions In this cohort, metabolic dysfunction, independent HCV, risk. addition HCV treatment population, cardiometabolic health should be optimized.

Language: Английский

Citations

0
Expanding Alcohol Use Disorder Medications in Primary Care DOI
Alisa B. Busch, Shelly F. Greenfield, Haiden A. Huskamp

et al.

JAMA Internal Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

This Viewpoint assesses prescription of medications to treat alcohol use disorder by primary care clinicians.

Language: Английский

Citations

0