Biosafety and Genomic Epidemiological Surveillance DOI Creative Commons
В. Г. Акимкин, Т. А. Семененко, K. Khafizov

et al.

Epidemiology and Vaccinal Prevention, Journal Year: 2024, Volume and Issue: 23(5), P. 4 - 12

Published: Nov. 6, 2024

The problem of biological safety is extremely relevant today for all countries the world because real and potential threats caused by agents that are dangerous to public health environment. Modern microorganisms becoming increasingly aggressive towards humans, as clearly demonstrated COVID-19 pandemic, which has affected aspects people's lives exposed vulnerability healthcare system. According Decree President Russian Federation «On Fundamentals State policy in field chemical period up 2025 beyond» Federal Law Biological Safety Federation», main objectives state reduce risks negative effects factors on population Antimicrobial resistance, emergence new infections overcoming interspecific barriers particular concern. Infectious disease with epidemic potential, such Ebola, Zika, Marburg, Lassa, MERS-CoV SARS-CoV viruses, continue pose a high threat. To counteract threats, Russia created scientific concept future biosafety, focusing development genomic epidemiological surveillance, digital transformation mobile technologies. Effective management processes requires constant monitoring genetic changes infectious prompt response allows VGARus platform monitor virus mutations. Thus, surveillance key element ensuring technological Russia.

Language: Английский

Epidemiologic Characteristics of the Novel Coronavirus Disease COVID-19 in the Armed Forces of the Republic of Kazakhstan Within the Framework of Parasitic Systems Self-Regulation Theory DOI

Aidos M. Khisamitov,

Aleksandr A. Kuzin,

A. E. Zobov

et al.

Russian Military Medical Academy Reports, Journal Year: 2025, Volume and Issue: 44(1), P. 71 - 78

Published: May 25, 2025

Background: The study of infectious disease epidemiology among military personnel has long been a priority in medicine. COVID-19 pandemic underscored the critical role pathogen genetic variability shaping patterns disease, serving as demonstrative case for applying Belyakov’s (1983) theory self-regulation parasitic systems. Although numerous studies have addressed epidemiologic aspects various organized communities, specific characteristics service members Armed Forces Republic Kazakhstan remain insufficiently studied, underscoring importance present research. AIM: to investigate novel coronavirus (COVID-19) through lens MATERIALS AND METHODS: A retrospective analysis was conducted assess incidence and civilian population Kazakhstan. Data were obtained from departmental medical statistical reports (Form 2/med) publicly available official statistics provided by National Center Public Health under Ministry comparative trends rates examined, along with identification features across military-administrative territories combination mathematical-statistical methods used data interpretation. RESULTS: demonstrated that genetically determined ability agent alter its epidemiologically significant properties (e.g., transmissibility, pathogenicity) response implemented anti-epidemic measures is key factor influencing epidemic intensity. This adaptation may manifest an increase number cases, changes severity clinical forms, shifts distribution groups, other patterns. CONCLUSION: plasticity pathogenic microorganisms, activated human characteristics, significantly influences regional spread. These must be considered when designing control systems structured settings.

Language: Английский

Citations

0
Epidemiological, cellular, genetic and epigenetic aspects of biosafety DOI
В. Г. Акимкин, В. В. Зверев, М. П. Кирпичников

et al.

Вестник Российской академии наук, Journal Year: 2024, Volume and Issue: 94(3), P. 287 - 298

Published: Aug. 15, 2024

Currently, the problem of biological safety is extremely relevant for all countries world due to expansion spectrum real and potential threats caused by exposure dangerous agents nature. The pandemic new coronavirus infection has clearly demonstrated its vulnerability world. inevitability occurrence future epidemics necessitates introduction scientific developments in field creation improvement methods amplification nucleic acids, identification pathogens using next-generation sequencing, genome editing technologies, etc. It seems advisable study reactions immune system recombinant microorganisms containing genes stimulators innate response order develop platforms universal vaccines active against a wide range pathogens. Based on analysis genomes transcriptomes, it possible identify targets (including RNA destroyed interference) that are most promising treatment prevention recurring infectious diseases. development an integrated approach implementation genomic epigenomic epidemiological surveillance system, taking into account latest achievements fundamental research virology, immunology, biotechnology, will make significant contribution ensuring Russian Federation.

Language: Английский

Citations

1
New Russian Trivalent Hepatitis B Vaccine (Bubo®­-Unigep): Reactogenicity, Safety and Immunological Efficacy DOI Creative Commons
V. N. Borisova,

R. Y. Maksvitis,

R. V. Ivanov

et al.

Epidemiology and Vaccinal Prevention, Journal Year: 2024, Volume and Issue: 23(3), P. 67 - 75

Published: July 10, 2024

Relevance. In Russia, phase III of clinical trials the domestic trivalent vaccine Bubo®-Unigep, containing protective antigens that provide protection against “wild” forms hepatitis B virus subtypes ay and ad, as well determinant serotype with G145R mutation, has been completed. Аim. Evaluation effect new recombinant polyvaccine «Bubo-Unigep» on vital functions laboratory parameters in previously unvaccinated individuals an adult healthy population. Materials methods. A randomized multicenter study was conducted to assess reactogenicity, safety immunogenicity Bubo®-Unigep (CJSC NPC «COMBIOTECH») adults (n = 166). The performed according protocol developed by contract research organization «R&D Pharma» at eight centers located Russian Federation. Results discussion. Analysis studied throughout (frequency severity adverse events, physical examination data volunteers assessment signs, test results, etc.) made it possible establish a high profile vaccine, which turned out be virtually areactogenic without causing development targeted local systemic post-vaccination events. Conclusion. wide range specificity immune response, along reactogenicity production can carried through full technological cycle use imported substances, will increase effectiveness prevention.

Language: Английский

Citations

0
Biosafety and Genomic Epidemiological Surveillance DOI Creative Commons
В. Г. Акимкин, Т. А. Семененко, K. Khafizov

et al.

Epidemiology and Vaccinal Prevention, Journal Year: 2024, Volume and Issue: 23(5), P. 4 - 12

Published: Nov. 6, 2024

The problem of biological safety is extremely relevant today for all countries the world because real and potential threats caused by agents that are dangerous to public health environment. Modern microorganisms becoming increasingly aggressive towards humans, as clearly demonstrated COVID-19 pandemic, which has affected aspects people's lives exposed vulnerability healthcare system. According Decree President Russian Federation «On Fundamentals State policy in field chemical period up 2025 beyond» Federal Law Biological Safety Federation», main objectives state reduce risks negative effects factors on population Antimicrobial resistance, emergence new infections overcoming interspecific barriers particular concern. Infectious disease with epidemic potential, such Ebola, Zika, Marburg, Lassa, MERS-CoV SARS-CoV viruses, continue pose a high threat. To counteract threats, Russia created scientific concept future biosafety, focusing development genomic epidemiological surveillance, digital transformation mobile technologies. Effective management processes requires constant monitoring genetic changes infectious prompt response allows VGARus platform monitor virus mutations. Thus, surveillance key element ensuring technological Russia.

Language: Английский

Citations

0