Signal pathways involved in contrast-induced acute kidney injury DOI Creative Commons
Ke Deng,

Mingxin Pei,

Beibei Li

et al.

Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 25, 2024

Contrast-induced acute kidney injury (CI-AKI) has emerged as a global public health concern, ranking the third most prevalent cause of hospital-acquired injury, which is related to adverse outcomes. However, its precise pathogenesis remains elusive. Consequently, researchers are dedicated uncovering CI-AKI's pathophysiology and signaling pathways, including inflammation, oxidative stress, apoptosis, ferroptosis, improve prevention treatment. This review thoroughly analyzes pathways their interactions associated with CI-AKI, assesses impact various research models on pathway analysis, explores more targeted treatment approaches. Aims furnish robust theoretical foundation for molecular mechanisms underpinning clinical treatments.

Language: Английский

Portrayal of NLRP3 Inflammasome in Atherosclerosis: Current Knowledge and Therapeutic Targets DOI Open Access
Daniela Maria Tănase, Emilia Valasciuc, Evelina Maria Gosav

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(9), P. 8162 - 8162

Published: May 3, 2023

We are witnessing the globalization of a specific type arteriosclerosis with rising prevalence, incidence and an overall cardiovascular disease burden. Currently, atherosclerosis increasingly affects younger generation as compared to previous decades. While early preventive medicine has seen improvements, research advances in laboratory clinical investigation promise provide us novel diagnosis tools. Given physio-pathological complexity epigenetic patterns discovery new molecules involved, therapeutic field room for substantial growth. Thus, scientific community is currently investigating role nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome, crucial component innate immune system different inflammatory disorders. NLRP3 activated by distinct factors numerous cellular molecular events which trigger inflammasome assembly subsequent cleavage pro-interleukin (IL)-1β pro-IL-18 pathways via caspase-1 activation, eliciting endothelial dysfunction, promotion oxidative stress inflammation process atherosclerosis. In this review, we introduce basic mechanisms activation its also emphasize promising pharmaceutical potential.

Language: Английский

Citations

28
Outer membrane vesicles from Pseudomonas aeruginosa induce autophagy-regulated pyroptosis in THP-1 cells DOI

Jing Ge,

Yaoyang Liu, Tianqi Wu

et al.

Archives of Microbiology, Journal Year: 2025, Volume and Issue: 207(3)

Published: Feb. 10, 2025

Language: Английский

Citations

1
Tetramethylpyrazine Confers Protection Against Oxidative Stress and NLRP3-Dependent Pyroptosis in Rats with Endometriosis DOI Creative Commons
Ke Xu, Mingzhe Zhang, Xiaofeng Zou

et al.

Organogenesis, Journal Year: 2025, Volume and Issue: 21(1)

Published: Feb. 18, 2025

Tetramethylpyrazine (TMP) has been confirmed to suppress inflammation in endometriosis (EMs). Herein, this study investigated whether and how TMP affected NLRP3 inflammasomes oxidative stress EMs. After establishment of an EMs rat model, rats were treated with different concentrations TMP. The size endometriotic lesions the latency frequency torsion recorded, followed by measurement relevant indicators (TNF-α, IL-6, IL-2, IL-10, MDA, SOD, GSH, CAT, ROS, NLRP3, ASC, GSDMD, caspase-1, Nrf2, HO-1). experimentally determined that treatment markedly decreased improved levels inflammatory proteins, markers, inflammasome, pyroptotic proteins elevated EMs, all which reversed upon treatment. Additionally, activities CAT lowered partly abrogated Furthermore, downregulation Nrf2 HO-1 was counteracted To sum up, represses excessive stress, inflammasome activation, pyroptosis may activate Nrf2/HO-1 pathway.

Language: Английский

Citations

1
Paeonol inhibits NETs-mediated foam cell inflammation through the CitH3/NLRP3/caspase-1 signaling pathway in atherosclerosis DOI
Xiaolin Ma,

Zhao Xuan,

Yulong Yang

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 151, P. 114340 - 114340

Published: Feb. 27, 2025

Language: Английский

Citations

1
Shuxuetong Injection inhibits pyroptosis in acute ischemic stroke via CD44/NLRP3/GSDMD signal DOI
Jinfeng Shang,

Guijinfeng Huang,

Bohong Wang

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119618 - 119618

Published: March 1, 2025

Language: Английский

Citations

1
Effect of reactive oxygen, nitrogen, and sulfur species on signaling pathways in atherosclerosis DOI

Kundan Solanki,

Evgeny E. Bezsonov, Alexander N. Orekhov

et al.

Vascular Pharmacology, Journal Year: 2024, Volume and Issue: 154, P. 107282 - 107282

Published: Feb. 5, 2024

Language: Английский

Citations

6
Iron accumulation and lipid peroxidation: implication of ferroptosis in diabetic cardiomyopathy DOI Creative Commons
Xuehua Yan, Yang Xie, Hongbing Liu

et al.

Diabetology & Metabolic Syndrome, Journal Year: 2023, Volume and Issue: 15(1)

Published: July 19, 2023

Diabetic cardiomyopathy (DC) is a serious heart disease caused by diabetes. It unrelated to hypertension and coronary artery can lead insufficiency, failure even death. Currently, the pathogenesis of DC unclear, clinical intervention mainly symptomatic therapy lacks effective objectives. Iron overdose mediated cell death, also known as ferroptosis, widely present in physiological pathological processes diabetes DC. key trace element human body, regulating metabolism glucose lipids, oxidative stress inflammation, other biological processes. Excessive iron accumulation imbalance antioxidant system activate aggravate such excessive autophagy mitochondrial dysfunction, resulting chain reaction accelerating myocardial microvascular damage. In-depth understanding mechanisms ferroptosis cardiovascular vessels help improve management. Therefore, this review, we summarize relationship between DC, well potential targets, discuss analyze limitations future development prospects these targets.

Language: Английский

Citations

13
Non-apoptotic cell death programs in cervical cancer with an emphasis on ferroptosis DOI
Mohammad Samare‐Najaf, Ali Samareh, Amir Savardashtaki

et al.

Critical Reviews in Oncology/Hematology, Journal Year: 2023, Volume and Issue: 194, P. 104249 - 104249

Published: Dec. 23, 2023

Language: Английский

Citations

13
Adrenomedullin Mitigates Doxorubicin-Induced Nephrotoxicity in Rats: Role of Oxidative Stress, Inflammation, Apoptosis, and Pyroptosis DOI Open Access
Rania Nagi Abd‐Ellatif, Nahla Anas Nasef, Hemat El‐Sayed El‐Horany

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(23), P. 14570 - 14570

Published: Nov. 23, 2022

Doxorubicin (DOX) is an anticancer antibiotic which has various effects in human cancers. It one of the commonly known causes drug-induced nephrotoxicity, results acute renal injury. Adrenomedullin (ADM), a vasodilator peptide, widely distributed many tissues and potent protective effects. Therefore, current study aimed to examine potential mechanisms ADM against DOX-induced nephrotoxicity. A total 28 male Wistar rats were randomized into four groups: control group, doxorubicin group (15 mg/kg single intraperitoneal injection DOX), adrenomedullin + (12 μg/kg/day ADM) 3 days prior DOX continuing for 14 after model was established, group. Kidney function biomarkers, oxidative stress markers, inflammatory mediators (TNF-α, NLRP3, IL-1β, IL-18) assessed. The expressions gasdermin D ASC assessed by real-time PCR. Furthermore, abundances caspase-1 (p20), Bcl-2, Bax immunoreactivity evaluated. administration improved biochemical parameters significantly reduced damage markers mediators, suppressed both apoptosis pyroptosis. These confirmed histopathological findings revealed that ADM's antioxidant, anti-inflammatory, anti-apoptotic, anti-pyroptotic properties may have prospective applications amelioration

Language: Английский

Citations

18
Deep-Learning-Driven Discovery of SN3–1, a Potent NLRP3 Inhibitor with Therapeutic Potential for Inflammatory Diseases DOI
Cheng Shi,

Tongfei Gao,

Weiping Lyu

et al.

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(19), P. 17833 - 17854

Published: Sept. 20, 2024

The NLRP3 inflammasome plays a central role in the pathogenesis of various intractable human diseases, making it an urgent target for therapeutic intervention. Here, we report development SN3-1, novel orally potent inhibitor, designed through lead compound strategy centered on deep-learning-based molecular generative models. Our enables rapid fragment enumeration and takes into account synthetic accessibility compounds, thereby significantly enhancing optimization compounds facilitating discovery inhibitors. X-ray crystallography provided insights SN3-1 inhibitory mechanism. has shown favorable safety profile both acute chronic toxicity assessments exhibits robust pharmacokinetic properties. Furthermore, demonstrated significant efficacy disease models characterized by activation. This study introduces candidate developing inhibitors expands repertoire tools available

Language: Английский

Citations

4