Correlation of β-adrenergic reactivity of erythrocyte membranes with clinical characteristics of patients with coronary artery disease and HF with preserved and reduced ejection fraction DOI Creative Commons
Э. Ф. Муслимова, В. А. Корепанов, Т. Yu. Rebrova

et al.

Russian Journal of Cardiology, Journal Year: 2024, Volume and Issue: 29(12), P. 5835 - 5835

Published: Aug. 9, 2024

Aim . To evaluate β-adrenergic reactivity of erythrocyte membranes (β-ARM) depending on clinical parameters in patients with heart failure (HF) preserved and reduced ejection fraction (EF), who had prior myocardial infarction. Material methods The sample included 89 HF past Preserved EF (HFpEF) group 64 (71,9%) patients, while (HFrEF) — 25 (28,1%) patients. All underwent β-ARM assessment using an inhibition hemolysis a hypoosmotic medium β-blocker. Results groups HFpEF HFrEF were comparable values. There was no linear relationship between LVEF. In the group, following differences revealed functional class (p=0,049): 42,5 (24,1; 61,9) CU I, 25,9 (17,1; 36,9) II, 22,2 (14,9; 27,3) III. This not observed (p=0,143). HFpEF, LV hypertrophy (p=0,049) higher values than without it (36,9 (24,2; 58,6) vs 23,3 (16,0; 29,8) CU). At same time, HFrEF, (p=0,364) hypertrophy. taking angiotensin-converting enzyme inhibitors/angiotensin receptor blockers at admission 2-fold lower (p=0,035) did take it. Conclusion infarction, low β-ARM. individuals differed from increased β-ARM, i.e., sympathoadrenal system intensity adrenergic reactivity, which group. associated more favorable indicators reactivity.

Language: Английский

Prospects for predicting and preventing the heart failure deterioration: an analytical review DOI Creative Commons
В. Н. Ларина, I. K. Skiba

Russian Journal of Cardiology, Journal Year: 2024, Volume and Issue: 29(9), P. 5854 - 5854

Published: June 10, 2024

Heart failure (CHF) is a syndrome characterized by progressive course with varying duration of stability period, frequent episodes clinical deterioration, despite the therapy. HF deterioration often leads to repitalizations and poor prognosis. A possible reduction in rehospitalization rate prognosis improvement early administration optimal therapy modernization non-drug approaches an urgent area research. An integrated approach using scales, algorithms relevant strategies can significantly improve treatment outcomes quality life patients HF.

Language: Английский

Citations

1
Modeling of Heart Failure with Cyclophosphamide DOI Open Access

E. M. Evgenieva,

A. V. Chernomordova,

S. V. Okovitiy

et al.

Journal Biomed, Journal Year: 2024, Volume and Issue: 20(3E), P. 182 - 186

Published: Nov. 19, 2024

The article presents the results of reproduction cyclophosphane model heart failure. Outbred mice weighing 18–26 g at onset experiment were used. All divided into two groups with 10 animals in each. first group was injected intraperitoneally cyclophosphamide a dose 15 mg/kg, five times for 21 days (day 1, 5, 10, 15, and 21). second intact animals. EchoCG performed on twice: baseline before (point 1) one week after last injection 2, day 28). presented experimental may be used study drug toxicity prevention methods, as well failure preserved left ventricular ejection fraction.

Language: Английский

Citations

0
Correlation of β-adrenergic reactivity of erythrocyte membranes with clinical characteristics of patients with coronary artery disease and HF with preserved and reduced ejection fraction DOI Creative Commons
Э. Ф. Муслимова, В. А. Корепанов, Т. Yu. Rebrova

et al.

Russian Journal of Cardiology, Journal Year: 2024, Volume and Issue: 29(12), P. 5835 - 5835

Published: Aug. 9, 2024

Aim . To evaluate β-adrenergic reactivity of erythrocyte membranes (β-ARM) depending on clinical parameters in patients with heart failure (HF) preserved and reduced ejection fraction (EF), who had prior myocardial infarction. Material methods The sample included 89 HF past Preserved EF (HFpEF) group 64 (71,9%) patients, while (HFrEF) — 25 (28,1%) patients. All underwent β-ARM assessment using an inhibition hemolysis a hypoosmotic medium β-blocker. Results groups HFpEF HFrEF were comparable values. There was no linear relationship between LVEF. In the group, following differences revealed functional class (p=0,049): 42,5 (24,1; 61,9) CU I, 25,9 (17,1; 36,9) II, 22,2 (14,9; 27,3) III. This not observed (p=0,143). HFpEF, LV hypertrophy (p=0,049) higher values than without it (36,9 (24,2; 58,6) vs 23,3 (16,0; 29,8) CU). At same time, HFrEF, (p=0,364) hypertrophy. taking angiotensin-converting enzyme inhibitors/angiotensin receptor blockers at admission 2-fold lower (p=0,035) did take it. Conclusion infarction, low β-ARM. individuals differed from increased β-ARM, i.e., sympathoadrenal system intensity adrenergic reactivity, which group. associated more favorable indicators reactivity.

Language: Английский

Citations

0