An overview of nanoparticles in drug delivery: Properties and applications

South African Journal of Chemical Engineering, Journal Year: 2023, Volume and Issue: 46, P. 233 - 270

Published: Aug. 22, 2023

Today, in diverse medical and clinical fields, including cancer treatment, nanoscience has evolved evolved. Cancer its forms, on the other hand, have been rumored inclusive, many individuals suffer from this fatal lethal condition. Actually, even with medicinal effect, current therapeutic approaches, chemotherapy, radiotherapy, etc., create symptoms that are inconvenient for patients. Scientists scholars also working to establish and, strengthen options methods of therapy deal dangerous illness. Nanoscience nanotechnology popular today, their different areas, nanoparticles, commonly used a number applications, especially drug delivery diagnostic products, cases imaging. Release mechanisms focused profound effect release drugs. Biomaterials bio-engineering developments leading novel approaches nanoparticles could offer new way patients improve. In method, Nano-technology had great selection cells, targeted drug, overcoming traditional chemotherapy limitations. This article discusses tumor tissue, method is more effective than methods, solved problem cell resistance provided field treatment cancer.

Language: Английский

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Nano titanium oxide (nano-TiO2): A review of synthesis methods, properties, and applications

Case Studies in Chemical and Environmental Engineering, Journal Year: 2024, Volume and Issue: 9, P. 100626 - 100626

Published: Jan. 24, 2024

Nanoparticles have revolutioned materials secience and manufacturing industry thanks to their ultrafine scale. Nano-scale titanium oxide (nano-TiO2) are key elements of a wide variety sectors advanced materials, devices, systems in view versatility extraordinary characetristics, mainly optical, electrical catalytic properties. Thnaks aforementioned features, they found position different industries such as colors pigments, photocatalysts, photovoltaic solar cells, adsorbents, cosmetics, electric electronic devices. Nano-SiO2 application gives rise range properties performance, which severely depends on particle size, size distribution, agglomeration the bulk host or systems. When used surface coating additive even functionalized, nano- TiO2 takes more roles, state-of-the-art depending synthesis method. Therefore, review synthesis, properties, surface- bulk-functionalization/modification (respectively with function groups doping) methods achieving high-performance seems essential. In this review, background information developments from pure Titanium Oxide chemically modified -based photocatalysts were discussed detail, Photocatalytic activity oxide-based nitrogen group pollutant decomposition. It also Vehicle for Chemotherapeutics Other Applications Medicine an overview factors affecting been reviewed.

Language: Английский

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Nanowires Properties and Applications: A Review Study

South African Journal of Chemical Engineering, Journal Year: 2023, Volume and Issue: 46, P. 286 - 311

Published: Aug. 22, 2023

One-dimensional nanostructures are generally cited as nanowires, nanofibers, nanotubes, and so on. The foremost prominent feature of these materials is their electrical conductivity, which, unlike classical physics, doesn't increase resistance because the diameter decreases. Numerous properties like optical, magnetic, biological, environmental sensory have created many applications for them altogether industries. nanowires (NWs) propose potential impact on electronics, computing, memory, data storage, communications, manufacturing, health, medicine, national security, other economic sectors well. NWs offer excellent surface-to-volume ratio (interface phenomena), low defect density, high optical output, controllable n-type making more appropriate sensitive sensing applications. with ultra-sensitive real-time detection capabilities lend in nano biosensors, chemical sensors, gas electrochemical sensors. been used improving absorption well collection efficacy photovoltaic devices. having small size, weight, cost mass production, also compatible commercial planar processes large-scale circuitry. In paper, authors focusing to summarize recent advances various fields such research, education, entertainment, power generation.

Language: Английский

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Adsorption of heavy metal ions use chitosan/graphene nanocomposites: A review study

Results in Chemistry, Journal Year: 2024, Volume and Issue: 7, P. 101332 - 101332

Published: Jan. 1, 2024

The emission of heavy metals in the environment has caused many problems world due to industrialization society and expansion urbanization. Environmental pollution, including greenhouse gases water-soluble toxic pollutants, is a major concern around world. One most important issues protecting health humans, animals plants cleanliness water. Water substance vital for all living things on planet. can be treated several ways, such as desalination, purification, osmosis, disinfection, deposition contaminants. Among these methods, adsorption method advantages over other methods. surface phenomenon during which contaminants are adsorbed adsorbent with physical forces depends factors temperature, pH, concentration contaminants, time phase contact particle size temperature nature pollutants adsorption. Chitosan received widespread attention an because its low cost great potentials. abundant hydroxyl amino groups that bind metal ions. However, it defects sensitivity thermal stability, mechanical strength, limit application chitosan wastewater treatment. functional modified improve performance via crosslinking graft modification. porosity specific area powder form not ideal, therefore, modification been attempted generate nanoparticles hydrogel. also integrated materials (e.g. graphene, zeolite) resulting composite improved performance. This review mainly focuses reports about derivatives remove different metals. preparation strategy, mechanism, affecting adsorbents each type discussed detail. Recent organic (dyes phenol) removal by briefly discussed.

Language: Английский

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Synthesis and Modification of Nanoparticles with Ionic Liquids: a Review

BioNanoScience, Journal Year: 2023, Volume and Issue: 13(2), P. 760 - 783

Published: March 2, 2023

Language: Английский

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Nano bioceramics: Properties, applications, hydroxyapatite, nanohydroxyapatite and drug delivery

Case Studies in Chemical and Environmental Engineering, Journal Year: 2024, Volume and Issue: 10, P. 100869 - 100869

Published: July 29, 2024

Bone is the second organ of human body that has most transplants. The concept bone repair evolved over past five decades and known as third generation biomaterials. During integration nanotechnology with bioceramics, an emerging research field called nanobioceramics been born within Due to chemical similarity mineral content bone, are included in definition a new biomaterials whose main purpose create microenvironment improve cellular responses leading osteogenesis. Hydroxyapatite member calcium phosphate family. This substance, which bioactive biocompatible compound, considered component tissue. structural this compound it widely used tissue dental orthopedic applications. Many basic properties hydroxyapatite can be improved by changing scale its particles nanoparticles. Therefore, recent years, various methods for synthesis nanohydroxyapatite have reported. Using different characterization methods, quality synthesized nanostructures checked. In addition bone-related fields, also carrier transfer materials, including drugs, vitamins, proteins. article, modern times, advances biomedical focusing on use bioceramics treatment diseases, function vital organs, engineering brought hopes regenerative medicine. Various being investigated synthesize bioceramic materials using natural synthetic materials. There several challenges enable cost-effective material minimize rejection biological systems. One major incorporating foreign into systems their acceptance reduce humans other organisms studying immune responses. When developing ceramic mechanical one important parameters humans. evaluation criteria mechanical, existing approaches play crucial role validating bioceramics. State-of-the-art techniques

Language: Английский

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An Updated Review of the Antimicrobial Potential of Selenium Nanoparticles and Selenium-Related Toxicological Issues

Future Pharmacology, Journal Year: 2025, Volume and Issue: 5(1), P. 3 - 3

Published: Jan. 8, 2025

Discovered in mid-1817 by Jöns Jacob Berzelius, selenium, belonging to Group 16 of the periodic table is an essential trace element for human and animal health, due its biocompatibility bioavailability. Additionally, it known having different oxidation states, which allows interact with distinct chemical elements form various compounds. Selenium exhibits two forms, organic inorganic; latter genotoxicity. nanoparticles have been investigated as alternative mitigate toxicity this element. With antidiabetic, antiviral, chemopreventive, antimicrobial properties, SeNPs possess significant biomedical potential can be synthesized using chemical, physical, or green methods, offering new solutions combating microbial resistance other diseases. This review discusses historical discovery preparation versatility combinations synthesis, morphological characteristics, sizes, well impact SeNP applications obtained through approaches against medically relevant microorganisms, particularly those exhibiting conventional antimicrobials.

Language: Английский

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Synergistic antibacterial activity of chitosan-polyethylene glycol nanocomposites films containing ZIF-8 and doxycycline

BMC Biotechnology, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 20, 2025

Antibiotic resistance is a growing global threat due to antibiotic overuse and limited treatment options. Multidrug-resistant bacteria, like Staphylococcus aureus Escherichia coli, increase infection complexity mortality. This study explores nanocomposite films of ZIF-8 nanoparticles Doxycycline (Dox) enhance antibacterial efficacy. In this study, composed chitosan (CS) polyethylene glycol (PEG), incorporating zeolitic imidazolate framework-8 (ZIF-8) DOX, were developed. These characterized by their morphological, mechanical, antibacterial, drug-release properties. Antibacterial efficacy was evaluated using disk diffusion, broth microdilution, checkerboard assay methods determine MICs potential synergistic effects. The demonstrated flexibility, semi-transparency, yellowish-brown hue, with containing being thicker (79 ± 0.2 μm) than those without (54 0.5 μm). tensile strength enhanced the incorporation ZIF-8, peaking at 53.12 MPa for CS-PEG-G-10% DOX-4% film. XRD analysis confirmed crystallinity distinct peaks observed each material. drug release studies revealed an initial burst followed sustained release, higher rates in acidic environments compared neutral alkaline media. film significantly activity, achieving lowest MIC values, particularly against S. (22.5 mm inhibition zone) E. coli (14 zone). Additionally, notable effect between DOX FICI values below 0.5. exhibits optimal properties, positioning it as strong candidate developing effective treatments multidrug-resistant pathogens.

Language: Английский

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Highly Sensitive Flexible SERS-Based Sensing Platform for Detection of COVID-19

Biosensors, Journal Year: 2022, Volume and Issue: 12(7), P. 466 - 466

Published: June 28, 2022

COVID-19 continues to spread and has been declared a global emergency. Individuals with current or past infection should be identified as soon possible prevent the of disease. Surface-enhanced Raman spectroscopy (SERS) is an analytical technique that potential used detect viruses at site therapy. In this context, SERS exciting because it provides fingerprint for any material. It many virus subtypes, including Deltacron Omicron, novel coronavirus. Moreover, flexible substrates, due their unique advantages sensitivity flexibility, have recently attracted growing research interest in real-world applications such medicine. Reviewing latest SERS-substrate developments crucial further development quality detection platforms. This article discusses ultra-responsive methods by substrate. Multiplex assays combine biomarkers and/or secondary diseases triggered are critical, according study. addition, we discuss how SERS-substrate-based ultrasensitive could transform disease diagnosis, control, surveillance future. study believed help researchers design manufacture substrates higher performance lower cost, ultimately better understand practical applications.

Language: Английский

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A review of nanoparticle synthesis methods, classifications, applications, and characterization

Environmental Nanotechnology Monitoring & Management, Journal Year: 2023, Volume and Issue: 20, P. 100900 - 100900

Published: Nov. 24, 2023

Language: Английский

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