Evaluation of Cytotoxicity and Metabolic Profiling of Synechocystis sp. Extract Encapsulated in Nano-Liposomes and Nano-Niosomes Using LC-MS, Complemented by Molecular Docking Studies DOI Creative Commons

Lamya Azmy,

Ibraheem Ibraheem,

Sulaiman A. Alsalamah

et al.

Biology, Journal Year: 2024, Volume and Issue: 13(8), P. 581 - 581

Published: July 31, 2024

Liposomes and niosomes can be considered excellent drug delivery systems due to their ability load all compounds, whether hydrophobic or hydrophilic. In addition, they reduce the toxicity of loaded without reducing its effectiveness. Synechocystis sp. is a unicellular, freshwater cyanobacteria strain that contains many bioactive compounds qualify use in industrial, pharmaceutical, other fields. This study investigated potential nano-liposomes (L) nano-niosomes (N) for delivering extract against cancer cell lines. Four different types nanoparticles were prepared using dry powder formulation ethanol both nanovesicles (N1 N2, respectively) liposomes (L1 L2, respectively). Analysis formed vesicles zeta analysis, SEM morphological visual examination confirmed stability efficiency. L1 L2 this investigation had effective diameters 419 847 nm, respectively, with PDI values 0.24 0.27. Furthermore, potentials found range from −31.6 mV −43.7 mV. Regarding N1 541 nm 1051 0.31 0.35, reported −22.2 mV, respectively. Metabolic profiling tentatively identified 22 metabolites (1–22) ethanolic extract. Its effect representative human cancers was studied vitro, specifically colon (Caco2), ovarian (OVCAR4), breast (MCF7) The results showed activities N1, L1, three lines, where cytotoxicity IC50 19.56, 33.52, 9.24 µg/mL compared 26.27, 56.23, 19.61 Caco2, OVCAR4, MCF7, On hand, exhibited 9.09, 11.42, 2.38 µg/mL, while N2 15.57, 18.17, 35.31 Meanwhile, formulations little on normal lines (FHC, OCE1, MCF10a). All evaluated silico epidermal growth factor receptor tyrosine kinase (EGFR). molecular docking compound 21 (1-hexadecanoyl-2-(9Z-hexadecenoyl)-3-(6′-sulfo-alpha-D-quinovosyl)-sn-glycerol), followed by 6 (Sulfoquinovosyl monoacylgycerol), 7 (3-Hydroxymyristic acid), 8 (Glycolipid PF2), 12 (Palmitoleic 19 (Glyceryl monostearate), highest binding affinities. These good hydrogen bond interactions key amino acid Lys721 as co-crystallized ligand. suggest hold promise future treatment development. Further research should focus clinical trials, assessments, pharmacological profiles translate approach into anticancer drugs.

Language: Английский

Survival predictors of older cancer patients in Bangladesh: A multicenter study DOI
Muhammad Rafiqul Islam,

Syeda Masuma Siddiqua,

Salman Bashar Al Ayub

et al.

Cancer Epidemiology, Journal Year: 2025, Volume and Issue: 96, P. 102794 - 102794

Published: March 6, 2025

Language: Английский

Citations

0
Setting Up Geriatric Oncology Clinical Services: Asian Geriatric Oncology Society Guidelines 2025 (Part 1) DOI Creative Commons

Purvish Parikh,

Joyita Banerjee,

Rejiv Rajendranath

et al.

South Asian Journal of Cancer, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Abstract In this article, the Asian Geriatric Oncology Society provides an overview on how to develop geriatric oncology services in clinical setting. This gives insight into rationale; key stakeholders; four essential components of services; multidisciplinary team and tumor boards; assessment screening protocols; data, research, audit; professional education, development, training; communication, awareness social medial utilization. second part we focus optimizing resource utilization constrained settings—dividing them “must have” “good have.”

Language: Английский

Citations

0
Evaluation of Cytotoxicity and Metabolic Profiling of Synechocystis sp. Extract Encapsulated in Nano-Liposomes and Nano-Niosomes Using LC-MS, Complemented by Molecular Docking Studies DOI Creative Commons

Lamya Azmy,

Ibraheem Ibraheem,

Sulaiman A. Alsalamah

et al.

Biology, Journal Year: 2024, Volume and Issue: 13(8), P. 581 - 581

Published: July 31, 2024

Liposomes and niosomes can be considered excellent drug delivery systems due to their ability load all compounds, whether hydrophobic or hydrophilic. In addition, they reduce the toxicity of loaded without reducing its effectiveness. Synechocystis sp. is a unicellular, freshwater cyanobacteria strain that contains many bioactive compounds qualify use in industrial, pharmaceutical, other fields. This study investigated potential nano-liposomes (L) nano-niosomes (N) for delivering extract against cancer cell lines. Four different types nanoparticles were prepared using dry powder formulation ethanol both nanovesicles (N1 N2, respectively) liposomes (L1 L2, respectively). Analysis formed vesicles zeta analysis, SEM morphological visual examination confirmed stability efficiency. L1 L2 this investigation had effective diameters 419 847 nm, respectively, with PDI values 0.24 0.27. Furthermore, potentials found range from −31.6 mV −43.7 mV. Regarding N1 541 nm 1051 0.31 0.35, reported −22.2 mV, respectively. Metabolic profiling tentatively identified 22 metabolites (1–22) ethanolic extract. Its effect representative human cancers was studied vitro, specifically colon (Caco2), ovarian (OVCAR4), breast (MCF7) The results showed activities N1, L1, three lines, where cytotoxicity IC50 19.56, 33.52, 9.24 µg/mL compared 26.27, 56.23, 19.61 Caco2, OVCAR4, MCF7, On hand, exhibited 9.09, 11.42, 2.38 µg/mL, while N2 15.57, 18.17, 35.31 Meanwhile, formulations little on normal lines (FHC, OCE1, MCF10a). All evaluated silico epidermal growth factor receptor tyrosine kinase (EGFR). molecular docking compound 21 (1-hexadecanoyl-2-(9Z-hexadecenoyl)-3-(6′-sulfo-alpha-D-quinovosyl)-sn-glycerol), followed by 6 (Sulfoquinovosyl monoacylgycerol), 7 (3-Hydroxymyristic acid), 8 (Glycolipid PF2), 12 (Palmitoleic 19 (Glyceryl monostearate), highest binding affinities. These good hydrogen bond interactions key amino acid Lys721 as co-crystallized ligand. suggest hold promise future treatment development. Further research should focus clinical trials, assessments, pharmacological profiles translate approach into anticancer drugs.

Language: Английский

Citations

1