Demographic, Epidemiologic, and Clinical Characteristics of Human Monkeypox Disease Pre- and Post-2022 Outbreaks: A Systematic Review and Meta-Analysis

Biomedicines, Journal Year: 2023, Volume and Issue: 11(3), P. 957 - 957

Published: March 20, 2023

(1) Background: In early May 2022, an increasing number of human monkeypox (mpox) cases were reported in non-endemic disparate regions the world, which raised concerns. Here, we provide a systematic review and meta-analysis mpox-confirmed patients presented peer-reviewed publications over 10 years before during 2022 outbreak from demographic, epidemiological, clinical perspectives. (2) Methods: A search was performed for relevant studies published Pubmed/Medline, Embase, Scopus, Google Scholar 1 January 2012 up to 15 February 2023. Pooled frequencies with 95% confidence intervals (CIs) assessed using random or fixed effect model due estimated heterogeneity true sizes. (3) Results: Out 10,163 articles, 67 met inclusion criteria, 31 cross-sectional included meta-analysis. Animal-to-human transmission dominant pre-2022 (61.64%), but almost all post-2022 had history contact, especially sexual contact. The pooled frequency MSM individuals 93.5% (95% CI 91.0-95.4, I2: 86.60%) only studies. male gender predominant both pre- outbreaks, mean age confirmed 29.92 (5.77-41, SD: 9.38). most common manifestations rash, fever, lymphadenopathy, malaise/fatigue. Proctalgia/proctitis (16.6%, 10.3-25.6, 97.76) anal/perianal lesions (39.8%, 30.4-49.9, 98.10) unprecedented outbreak, not described before. Genitalia involvement more mpox (55.6%, 51.7-59.4, 88.11). (4) Conclusions: There are speculations about possibility changes pathogenic properties virus. It seems that experience milder disease fewer rashes lower mortality rates. Moreover, vast majority managed on outpatient basis. Our study could serve as basis ongoing investigations identify different aspects previous outbreaks compare them current ones.

Language: Английский

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Monkeypox Outbreak in Peru

Medicina, Journal Year: 2023, Volume and Issue: 59(6), P. 1096 - 1096

Published: June 6, 2023

Monkeypox (Mpox) is a zoonotic disease caused by the Orthopoxvirus monkeypox virus (MPXV). Since 1970, outbreaks of MPXV have occurred in several Sub-Saharan African countries. However, from May 2022 to April 2023, recent Mpox countries outside Africa, and these cases quickly spread over 100 non-endemic on all continents. Most were found region Americas Europe region. In Latin America, highest all-age rates per million inhabitants Peru, Colombia, Chile, Brazil. Given its global impact, was declared as an international Public Health Emergency WHO July 2022. infection disproportionately affects men who sex with members HIV-infected population. Vaccination current strategy for controlling preventing high-risk groups. this context, Peru has fourth-highest number America faces significant challenges control. Because this, review, we discuss epidemiology, public health indicators, prevention outbreak so that authorities can join forces control transmission.

Language: Английский

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Mpox severity and associated hospitalizations among people with HIV and related immunosuppression in Brazil

AIDS, Journal Year: 2023, Volume and Issue: 38(1), P. 105 - 113

Published: Oct. 9, 2023

Objectives: This study aimed to analyze characteristics of mpox hospitalization in a Brazilian cohort, further exploring the impact HIV on mpox-related outcomes and hospitalization. Design: We conducted descriptive analysis, comparing individuals diagnosed with according status, described cases among those living HIV. Methods: was single-center, prospective cohort at major infectious diseases referral center Rio de Janeiro, Brazil, that enrolled participants older than 18 years age mpox. Information collected standardized forms, including data sociodemographic, behavioral, clinical laboratory characteristics. For comparisons, we used chi-squared, Fisher's exact Moods median tests whenever appropriate. Results: From June December, 2022, 418 mpox, whom 52% were people (PWH). PWH presented more frequently fever, anogenital lesions proctitis. The overall rate 10.5% ( n = 43), especially for pain control. Among hospitalized participants, had proctitis required invasive support. Mpox severity related poor continuum care low CD4 + cell counts. All deaths 2) occurred less 50 cells/μl. Conclusion: HIV-related immunosuppression likely impacts outcomes. is special concern settings adherence late presentation socioeconomic inequalities, such as Brazil. must be taken into account when responding outbreak.

Language: Английский

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Clinical and epidemiological characteristics of mpox: A descriptive cases series in Colombia

Travel Medicine and Infectious Disease, Journal Year: 2023, Volume and Issue: 53, P. 102594 - 102594

Published: May 1, 2023

Colombia is the fifth most affected country by global monkeypox outbreak and second in LAC after Brazil. We describe clinical epidemiological characteristics of 521 patients with mpox country.We conducted an observational analysis laboratory-confirmed Mpox cases between June 29 November 16, 2022.Most were young men living HIV. The evolution was primarily benign, two deaths reported. found some differences women regarding their BMI, presence lymphadenopathies, localization lesions, antecedent HIV infection.Although it seems that epidemic curve for this decreasing not only but globally, could remain endemic. Therefore, necessary to maintain very close surveillance.

Language: Английский

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Demographic and clinical characteristics of people diagnosed with active sexually transmitted infections among monkeypox cases in Brazil: the 2022 outbreak

Revista do Instituto de Medicina Tropical de São Paulo, Journal Year: 2024, Volume and Issue: 66

Published: Jan. 1, 2024

The worldwide monkeypox (mpox) outbreak in 2022 showed a high frequency of sexually transmitted infections (STI). A cross-sectional study was carried out using secondary data from the Brazilian official mpox surveillance systems. total 10,169 cases were identified, with median age 32 years. Among them, 92.3% male at birth and 57.5% men who have sex other (MSM). Approximately 11% diagnosed STI, including 5.8% syphilis 2.5% genital herpes. Individuals aged 25 to 34 years, MSM, individuals HIV-positive status, those manifesting skin eruptions or penile edema associated STI. Laboratory investigation for must be implemented as priority STI clinics (especially MSM) mitigate neglected cases, ensure appropriate treatments, prevent misdiagnoses.

Language: Английский

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Mpox Cases in Serbia, 2022

Infectious Disease Reports, Journal Year: 2025, Volume and Issue: 17(1), P. 9 - 9

Published: Jan. 27, 2025

On 23 July 2022, the World Health Organization (WHO) declared mpox multi-country outbreak as a Public Emergency of International Concern. This study aimed to identify epidemiological and clinical characteristics confirmed cases reported in Serbia 2022. The WHO case definition was used. Incidence rates (IRs) incidence rate ratios (IRRs) by age groups nomenclature territorial units for statistics level 3 (NUTS-3) with 95% confidence intervals (CIs) were calculated. Between June October 43 laboratory-confirmed reported. All unvaccinated males, mean 34 (±7.4) years. Out total, 72.1% men who have sex (MSM), sexual intercourse either multiple or unknown partners (p < 0.01). Fifteen (34.9%) lived HIV, mostly 30-39 group = 0.023). People living Belgrade City NUTS-3 six times more likely become infected compared South Backa citizens (IRR: 6.03, CI: 1.47-25.53). In Serbia, mainly affected MSM aged urban areas. promotion vaccine implementation should be prioritized populations higher risk.

Language: Английский

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Notified cases of mpox in the city of Rio de Janeiro, Brazil: a descriptive study, 2022

Epidemiologia e Serviços de Saúde, Journal Year: 2024, Volume and Issue: 33

Published: Jan. 1, 2024

ABSTRACT Objective To describe the profile of cases mpox in city Rio de Janeiro between June and November 2022. Methods This was a descriptive study secondary data obtained from notification forms. Socioeconomic, clinical spatial were analyzed. Results Of 928 cases, 93.7% male, 85.0% cisgender 65.6% homosexual, 41.8% 30 39 years old, 41.0% White race/skin color. A total 34.5% had immunosuppression due to illness, 41.9% reported their HIV status as being positive. The most prevalent signs symptoms were: skin lesions (96.6%), especially with multiple manifestations (67.8%) genital region (46.1%), addition fever (58.3%), adenomegaly (43.3%) headache (38.7%). Most notifications occurred public services (81.3%) hospital care (51.3%). Conclusion revealed high incidence mpox, among young, homosexual men. mild, lesions, progressing cure without hospitalization. Person-to-person transmission predominant.

Language: Английский

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Epidemiological and clinical characteristics of mpox cases: correspondence

Epidemiologia e Serviços de Saúde, Journal Year: 2023, Volume and Issue: 32(1)

Published: Jan. 1, 2023

Language: Английский

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Spectrum of ophthalmic manifestations in monkeypox virus infection worldwide: Systematic review and meta-analysis

Heliyon, Journal Year: 2023, Volume and Issue: 9(8), P. e18561 - e18561

Published: July 22, 2023

Mpox virus infection is a significant public health concern worldwide due to its potential severity and the likelihood of outbreaks occurring across different regions. Ophthalmic manifestations disease have been linked with more severe cases, leading need for hospitalization antiviral therapy. A systematic review meta-analysis were conducted following PRISMA guidelines summarize literature available on this topic. The revealed that ophthalmic manifestations, such as conjunctivitis periocular umbilicated lesions, are most common in infections. However, corneal opacity, can potentially cause blindness may also occur. Antiviral treatment tecovirimat topical management be considered cases. evidence quality poor predominance case reports imprecise characterization manifestations. Overall, ophthalmologists healthcare professionals should aware these early diagnosis timely treatment.

Language: Английский

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In vitro susceptibility of eighteen clinical isolates of human monkeypox virus to tecovirimat

Memórias do Instituto Oswaldo Cruz, Journal Year: 2023, Volume and Issue: 118

Published: Jan. 1, 2023

BACKGROUND In 2022, an outbreak of mpox that started in European countries spread worldwide through human-to-human transmission. Cases have been mostly mild, but severe clinical presentations reported. these cases, tecovirimat has the drug choice to treat patients with aggravated disease. OBJECTIVES Here we investigated susceptibility 18 isolates monkeypox virus (MPXV) obtained from different regions Brazil. METHODS Different concentrations were added cell monolayers infected each MPXV isolate. After 72 hours, cells fixed and stained for plaque visualization, counting, measurement. The ortholog F13L gene isolate was polymerase chain reaction (PCR)-amplified, sequenced, predicted protein sequences analyzed. FINDINGS eighteen generated plaques sizes. Although all highly sensitive drug, two showed response curves IC50 values. However, target tecovirimat, F13 (VP37), 100% conserved therefore does not explain difference sensitivity. MAIN CONCLUSIONS Our results support screening as important tool better use restricted number doses available low-income mpox.

Language: Английский

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