Antimicrobial potential of strontium against bacteria associated with peri-implantitis DOI Open Access
Hatem Alshammari

Published: Jan. 1, 2023

Dental implants are nowadays a standard treatment to replace missing teeth and restore function aesthetics. However, biological complications associated with implants, e.g., peri-implant infections, common jeopardize the success of treatment. The main aim this thesis was explore strontium (Sr) as possible prevention strategy against since Sr has been shown have antibacterial action also promote titanium (Ti) implant osseointegration. In thesis, systematic appraisal literature about antimicrobial potential Sr-functionalized Ti surfaces for oral applications performed, followed by series in vitro studies assessing micro-organisms peri-implantitis. Study I, resulted an initial list 1081 potentially relevant publications, where from nine publications met inclusion criteria. Most included showed that exerted limited immediate (i.e., 24 h) effect, likely due low ion release; effect biofilm inhibition Streptococcus aureus observed at both early late timepoints, adequate release. II assessed, vitro, five different concentrations soluble Sr(OH)2 (100, 10, 1, 0.1, 0.01 mM) 6 mono-species bacteria (Streptococcusmitis, Staphylococcus epidermidis, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Escherichia coli, Fusobacterium nucleatum) terms cell growth, minimal inhibitory concentration (MIC), viability. agar diffusion test, zones were only 0.01, 1 mM P. gingivalis. Growth planktonic cultures achieved 10 all species tested. viability assay, 100 potent bactericidal S. mitis, A. E. It thus concluded properties III assessed early- bacteriostatic wafers on peri-implantitis (E. coli,S. aureus, oralis, Actinomyces naeslundii, Parvimonas micra, P.gingivalis F. after 2 hours, multispecies day 3, 6. wafers, compared controls, statistically significant less viable cells mono- tests. Number colony forming units (CFUs) within significantly higher time-points evaluation coli 1. Gingipain activity ones, qPCR gingivalis comprised 15% total 6, while it remained below detection levels Sr-coated wafers. IV, impact surface roughness (turned vs moderately rough) bacterial (S. nucleatum, coli), grown consortia, vitro. Bacterial formation, well as, proteolytic reduction number nonfunctionalized times investigation Higher found non-functionalized disks ones. Sr-functionalised notable growth remined undetected time points disks. turned had slightly release rough first sustained up 15 days. Overall, data generated projects indicate exerts is worthwhile further infections.

Language: Английский

Ceramic Biomaterials in Dental Implantology—Time for Change of Status Quo: An Updated Review DOI Open Access
Lakshmi Thangavelu, R. P. Parameswari,

Mithun Athiraj Anaiambalam Tharmar

et al.

World Journal of Dentistry, Journal Year: 2024, Volume and Issue: 15(8), P. 733 - 742

Published: Dec. 4, 2024

Language: Английский

Citations

0
EVALUATION OF EXPRESSION OF SALIVARY ICTP BIOMARKER IN PERIODONTITIS PATIENTS – AN OBSERVATIONAL STUDY DOI Open Access

Johnmanohar Johnisha Harris,

Gurumoorthy Kaarthikeyan

BULLETIN OF STOMATOLOGY AND MAXILLOFACIAL SURGERY, Journal Year: 2024, Volume and Issue: unknown, P. 11 - 18

Published: Dec. 16, 2024

Objectives: Pyridinoline cross-linked carboxyterminal telopeptide of type I collagen (ICTP) is released during the breakdown Type which primary event happens in periodontitis. In this study, we intention to find if ICTP biomarker can be used diagnosis Materials and methods: 30 patients were included. On clinical examination, they divided into 3 groups 10 healthy, chronic periodontitis with diabetes patients. Unstimulated saliva was collected from these Presence salivary assessed using ELISA qPCR. Results: The highest levels seen Group periodontitis, followed by group 2 1. A statistically significant difference observed when compared 1 similarly 2. Conclusion: Significant between gingivitis proved that as a tool for

Language: Английский

Citations

0
Response to adjunctive antibiotic therapy along with nonsurgical periodontal therapy in the treatment of peri-implantitis and chronic periodontitis patients: An exploratory review DOI Creative Commons

Gulshan Rai Sethi,

Vishakha Grover,

Jyoti Gupta

et al.

Journal of Indian Society of Periodontology, Journal Year: 2024, Volume and Issue: 28(4), P. 393 - 406

Published: July 1, 2024

This review was conducted to assess and compare whether there is a difference in response adjunctive systemic locally delivered antibiotics along with nonsurgical periodontal therapy (NSPT) the treatment of peri-implantitis (PI) chronic periodontitis (CP). A systematic search literature on predefined criteria using PubMed, Embase, Scopus. Probing pocket depth, bleeding probing, clinical attachment level, microbial load reduction were selected as primary outcomes, whereas plaque index gingival evaluated secondary outcomes. Standard Cochrane risk-of-bias tools used for quality assessment included studies, qualitative data synthesis owing observed heterogeneity extracted data. Adjunctive local NSPT resulted additional beneficial effects cases both CP PI, greater improvement compared PI. Even among antibiotics, minocycline only antibiotic some significant benefits, when documented. Within limitations review, it concluded that use offers effect management PI; however, insufficient direct evidence regarding comparative efficacy PI CP.

Language: Английский

Citations

0
Localized Drug Delivery Using Linezolid Hydrogel for Periodontal Therapy DOI
Iria Seoane‐Viaño,

Mariola Seoane-Gigirey,

Carlos Bendicho-Lavilla

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0
Antimicrobial potential of strontium against bacteria associated with peri-implantitis DOI Open Access
Hatem Alshammari

Published: Jan. 1, 2023

Dental implants are nowadays a standard treatment to replace missing teeth and restore function aesthetics. However, biological complications associated with implants, e.g., peri-implant infections, common jeopardize the success of treatment. The main aim this thesis was explore strontium (Sr) as possible prevention strategy against since Sr has been shown have antibacterial action also promote titanium (Ti) implant osseointegration. In thesis, systematic appraisal literature about antimicrobial potential Sr-functionalized Ti surfaces for oral applications performed, followed by series in vitro studies assessing micro-organisms peri-implantitis. Study I, resulted an initial list 1081 potentially relevant publications, where from nine publications met inclusion criteria. Most included showed that exerted limited immediate (i.e., 24 h) effect, likely due low ion release; effect biofilm inhibition Streptococcus aureus observed at both early late timepoints, adequate release. II assessed, vitro, five different concentrations soluble Sr(OH)2 (100, 10, 1, 0.1, 0.01 mM) 6 mono-species bacteria (Streptococcusmitis, Staphylococcus epidermidis, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Escherichia coli, Fusobacterium nucleatum) terms cell growth, minimal inhibitory concentration (MIC), viability. agar diffusion test, zones were only 0.01, 1 mM P. gingivalis. Growth planktonic cultures achieved 10 all species tested. viability assay, 100 potent bactericidal S. mitis, A. E. It thus concluded properties III assessed early- bacteriostatic wafers on peri-implantitis (E. coli,S. aureus, oralis, Actinomyces naeslundii, Parvimonas micra, P.gingivalis F. after 2 hours, multispecies day 3, 6. wafers, compared controls, statistically significant less viable cells mono- tests. Number colony forming units (CFUs) within significantly higher time-points evaluation coli 1. Gingipain activity ones, qPCR gingivalis comprised 15% total 6, while it remained below detection levels Sr-coated wafers. IV, impact surface roughness (turned vs moderately rough) bacterial (S. nucleatum, coli), grown consortia, vitro. Bacterial formation, well as, proteolytic reduction number nonfunctionalized times investigation Higher found non-functionalized disks ones. Sr-functionalised notable growth remined undetected time points disks. turned had slightly release rough first sustained up 15 days. Overall, data generated projects indicate exerts is worthwhile further infections.

Language: Английский

Citations

1