Lentiviral Injection of Inter-α-Trypsin Inhibitor Heavy Chain 4 Promotes Female Spinal Cord Injury Mice Recuperation by Diminishing Peripheral and Central Inflammation
Inflammation,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 9, 2024
Language: Английский
A Prospective Cohort Study of Inter-Alpha-Trypsin Inhibitor Heavy Chain 4 as a Serologic Marker in Relation to Severity and Functional Outcome of Acute Intracerebral Hemorrhage
Hua-Song Shentu,
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Yi‐Hua Chen,
No information about this author
Zhenyu Cheng
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et al.
Neuropsychiatric Disease and Treatment,
Journal Year:
2023,
Volume and Issue:
Volume 19, P. 2363 - 2379
Published: Nov. 1, 2023
Background:
The
inter-alpha-trypsin
inhibitor
heavy
chain
4
(ITIH4)
may
regulate
immunity
and
inflammation.
current
study
was
conducted
to
determine
its
role
as
a
biomarker
for
reflecting
the
severity
predicting
outcomes
of
intracerebral
hemorrhage
(ICH).
Methods:
In
this
prospective
cohort
study,
185
patients
with
supratentorial
ICH
were
enrolled,
among
whom
62
had
blood
obtained
not
only
at
admission
but
also
on
days
1,
3,
5,
7,
10,
14.
addition,
healthy
controls
underwent
collection
start
study.
serum
ITIH4
levels
then
quantified.
We
recorded
early
neurological
deterioration
(END)
poor
prognosis
(modified
Rankin
Scale
[mRS]
scores
3–
6])
six
months
after
ICH.
Results:
Serum
decreased
prominently
in
phase
ICH,
continued
decline
until
day
gradually
increased
14,
significantly
lower
during
14
than
controls.
independently
associated
C-reactive
protein
levels,
National
Institutes
Health
Stroke
(NIHSS)
hematoma
volume.
Admission
mRS
scores,
END,
prognosis.
No
substantial
differences
existed
areas
under
receiver
operating
characteristic
curve
END
prediction
between
NIHSS
Prediction
models,
which
volume
integrated,
relatively
reliable
stable
using
series
statistical
methods.
model
higher
discriminatory
ability
alone.
Conclusion:
A
dramatic
period
following
is
related
inflammatory
response,
stroke
severity,
neurologic
outcomes,
suggesting
that
be
useful
prognostic
Keywords:
4,
hemorrhage,
deterioration,
prognosis,
biomarkers
Language: Английский
Usability of serum inter-α-trypsin inhibitor heavy chain 4 as a biomarker for assessing severity and predicting functional outcome after human aneurysmal subarachnoid hemorrhage: A prospective observational cohort study at a single institution
Heping Tian,
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Genghuan Wang,
No information about this author
Qi Zhong
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et al.
Clinica Chimica Acta,
Journal Year:
2023,
Volume and Issue:
552, P. 117679 - 117679
Published: Nov. 23, 2023
Language: Английский
Plasma alpha-trypsin inhibitor heavy chain 4 as an age-specific biomarker in the diagnosis and treatment of major depressive disorder
Ping He,
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Xuefang Lu,
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Mengmeng Zhong
No information about this author
et al.
Frontiers in Psychiatry,
Journal Year:
2024,
Volume and Issue:
15
Published: Sept. 11, 2024
The
diagnosis
of
major
depressive
disorder
(MDD)
mainly
depends
on
subjective
clinical
symptoms,
without
an
acceptable
objective
biomarker
for
the
application
MDD.
Inter-alpha-trypsin
inhibitor
heavy
chain
4
(ITIH4)
showed
a
high
specificity
as
and
treatment
present
study
aimed
to
investigate
differences
in
plasma
ITIH4
two
different
aged
MDD
patients
underlying
pathological
mechanisms
occurrence
development
Language: Английский