Airborne micro- and nanoplastics: emerging causes of respiratory diseases DOI Creative Commons
Zixuan Gou, Haonan Wu, Shanyu Li

et al.

Particle and Fibre Toxicology, Journal Year: 2024, Volume and Issue: 21(1)

Published: Dec. 4, 2024

Airborne micro- and nanoplastics (AMNPs) are ubiquitously present in human living environments pose significant threats to respiratory health. Currently, much research has been conducted on the relationship between (MNPs) cardiovascular gastrointestinal diseases, yet there is a clear lack of understanding regarding link AMNPs diseases. Therefore, it imperative explore two. Recent extensive studies by numerous scholars characteristics their with diseases have robustly demonstrated that from various sources significantly influence onset progression conditions. Thus, investigating intrinsic mechanisms involved finding necessary preventive therapeutic measures crucial. In this review, we primarily describe fundamental AMNPs, impact system, toxic facilitate disease development. It hoped article will provide new insights for further contribute advancement

Language: Английский

Assessing microplastic and nanoplastic contamination in bird lungs: evidence of ecological risks and bioindicator potential DOI
Mengzhu Wang, Peng Zhou, Shane G. DuBay

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 487, P. 137274 - 137274

Published: Jan. 17, 2025

Language: Английский

Citations

4
Emamectin Benzoate and Microplastics Led to Skeletal Muscle Atrophy in Common Carp via Induced Oxidative Stress, Mitochondrial Dysfunction, and Protein Synthesis and Degradation Imbalance DOI
Wenying Sun, Jing Liu, Xu Shi

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Pesticides and plastics have brought convenience to agricultural production daily life, but they also led environmental pollution through residual chemicals. Emamectin benzoate (EMB) is among the most widely used insecticides, which can cause harm health of organisms. Additionally, microplastics (MPs), a relatively new type pollutant, not only are increasing in amounts within water bodies aquatic organisms exacerbate by adsorbing other pollutants, leading mixed scenario. Nevertheless, toxicity mechanism EMB MPs on common carp skeletal muscle been elucidated. Therefore, we established exposure models for MPs, methods such as hematoxylin eosin staining, immunofluorescence JC-1 western blotting were employed investigate underlying mechanisms damage. The results vivo vitro experiments indicated that or oxidative stress, turn caused mitochondrial fusion/fission imbalance (with decreased Mfn1, Mfn2, OPA1 increased DRP1), reduced membrane potential, ATP content, protein synthesis, degradation, ultimately resulting atrophy. Joint more severe damage than single exposure, addition NAC effectively alleviate In summary, and/or induced excessive reactive oxygen species (ROS) production, giving rise dysfunction an synthesis atrophy carp.

Language: Английский

Citations

4
Enhancing the aging of polystyrene microplastics through a flow-through electrochemical membrane system: Mechanism of confinement effect DOI
Cong Li,

Lixia Shi,

Jing Ding

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 488, P. 137478 - 137478

Published: Feb. 3, 2025

Language: Английский

Citations

1
A particle of concern: explored and proposed underlying mechanisms of microplastic-induced lung damage and pulmonary fibrosis DOI
R. K. Gautam,

Laltanpuia,

Nishant Singh

et al.

Inhalation Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17

Published: Feb. 11, 2025

In the past decade, microplastics (MPs) have drawn significant attention as widespread environmental contaminants, with research increasingly highlighting their harmful effects on respiratory health in aquatic and terrestrial organisms. Findings revealed human lung tissues, raising concerns about potential role damaging tissue integrity contributing to pulmonary fibrosis-a chronic inflammatory condition characterized by scarring of epithelial tissues due accumulated extracellular matrix, triggered factors such alcohol, pathogens, genetic mutations, pollutants. this review, we explore both well-studied lesser-studied mechanisms signaling pathways, aiming shed light how might act mediators that activate distinct, often overlooked cascades. This review searched PubMed Google Scholar using keywords like "plastic," "microplastic," "lung fibrosis," "pulmonary system," "exposure route," "signaling pathways," combined "OR" "AND" singular plural forms. These pathways could not only induce damage but also play a development fibrosis. be targeted reduce microplastic-induced fibrosis, opening new avenues for future treatments.

Language: Английский

Citations

1
2-Ethylhexyl diphenyl phosphate induces lung oxidative stress and pyroptosis in chicks DOI Creative Commons

Yiming Sun,

Ruili Zhang, Jiali Li

et al.

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 962, P. 178453 - 178453

Published: Jan. 1, 2025

Language: Английский

Citations

0
The association between micro- and nano-plastics and cardiovascular outcomes: a comprehensive review DOI

Soroush Oraee,

Mohammadreza Alinejadfard,

Sajjad Mahdavi

et al.

Toxicology and Environmental Health Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Language: Английский

Citations

0
Birds as Bioindicators: Revealing the Widespread Impact of Microplastics DOI Creative Commons
Lara Carrasco Pesquera,

Eva Jiménez-Mora,

Maria Jose Utrilla

et al.

Birds, Journal Year: 2025, Volume and Issue: 6(1), P. 10 - 10

Published: Feb. 11, 2025

The global crisis of plastic pollution, particularly involving microplastics (MPs) and nanoplastics (NPs), has profound ecological implications. Birds, serving as bioindicators, are especially susceptible to these pollutants. This systematic review synthesizes the current research on presence, distribution, impact MPs NPs avian species, alongside advancements in detection methodologies. have been identified over 200 bird species across 46 families, encompassing several ecosystems, from Antarctica Labrador, including Australia, China, South Europe. Seabirds such penguins, gulls, shearwaters exhibit a high burden tissues feces due fishing debris, while terrestrial face contamination urban agricultural sources. Depending their composition, can cause gastrointestinal damage, oxidative stress, bioaccumulation toxic chemicals, polyethylene polypropylene. However, challenges persist methodological inconsistencies, though advances spectroscopy flow cytometry offer improved accuracy. Addressing this pollution is vital for conservation ecosystem health, requiring international collaboration standardized protocols.

Language: Английский

Citations

0
Deep learning-driven behavioral analysis reveals adaptive responses in Drosophila offspring after long-term parental microplastic exposure DOI
Chuanyong Wang, Jie Shen

Journal of Environmental Management, Journal Year: 2025, Volume and Issue: 376, P. 124502 - 124502

Published: Feb. 15, 2025

Language: Английский

Citations

0
Lactobacillus plantarum Reduces Polystyrene Microplastic Induced Toxicity via Multiple Pathways: A Potentially Effective and Safe Dietary Strategy to Counteract Microplastic Harm DOI

Liuting Shi,

Changyin Wu, Yimin Wang

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 489, P. 137669 - 137669

Published: Feb. 18, 2025

Language: Английский

Citations

0
New findings on the antagonism of the environmental chemical toxicity 2-ethylhexyl diphenyl phosphate: Glycyrrhizic Acid as an Nrf2 activator targets Nrf2/ROS/STAT3 signalling crosstalk to alleviate thymic injury in chicks DOI Creative Commons

Linghuan Luo,

Ming Ge,

Yiming Sun

et al.

Poultry Science, Journal Year: 2025, Volume and Issue: 104(4), P. 104918 - 104918

Published: Feb. 25, 2025

2-Ethylhexyl diphenyl phosphate (EHDPHP) is a pervasive environmental pollutant known to induce oxidative damage in organisms; however, its precise mechanisms of toxicity remain unclear. Furthermore, limited research has been conducted on potential therapeutic agents counteract EHDPHP toxicity. Glycyrrhizic acid (GA), triterpenoid saponin compound with recognized antioxidant, anti-inflammatory, and immunomodulatory properties, represents promising candidate for mitigating EHDPHP-induced injury. In chickens, the thymus main immune organ. This study aims investigate mechanism role GA intervention this process. A 'EHDPHP/GA-Target-Oxidative Stress (OS)' network was constructed using biology. model chicken thymic injury established by continuous oral administration (160 mg/kg) 42 days. Moreover, action which antagonizes explored MDCC-MSB1 cells vitro. Network biology analyses showed that 'EHDPHP/GA-OS' targets were mainly enriched adipocytokine apoptotic signaling pathways. Molecular docking demonstrated binding interactions Kelch-like ECH-associated protein 1 (Keap1), nuclear factor erythroid 2-related 2 (Nrf2), signal transducer activator transcription 3 (STAT3) proteins. Both vitro vivo experiments revealed attenuated cells, as evidenced reductions stress markers (ROS, MDA, T-AOC, SOD, GSH-Px), inflammation factors (NF-κB, IL-6, TNF-α), (Caspase 3) expression. treatment increased expression Nrf2 HO-1 while reducing Keap1, JAK1, Phospho-JAK1 (P-JAK1), STAT3, Phospho-STAT3 (P-STAT3). protective effect against cell injury, well inhibition JAK1/STAT3 pathway, diminished inhibitor ML385. These findings suggest exerts effects through mitigates chickens modulating crosstalk between Nrf2/ROS/STAT3 Overall, highlights novel treating underscores application diseases treatable activators.

Language: Английский

Citations

0