Long-Term Safety and Efficacy of Lacosamide Combined with NOACs in Post-Stroke Epilepsy and Atrial Fibrillation: A Prospective Longitudinal Study DOI Open Access
Marilena Mangiardi, Francesca Romana Pezzella, Alessandro Cruciani

et al.

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(12), P. 1125 - 1125

Published: Nov. 27, 2024

Background and Aims: Stroke is the leading cause of seizures epilepsy in adults; however, current guidelines lack robust recommendations for treating post-stroke (PSSs) (PSE). This study aims to demonstrate long-term safety efficacy lacosamide combined with non-vitamin K antagonist oral anticoagulants (NOACs) patients PSE atrial fibrillation (AF). Methods: In this prospective longitudinal single-center study, 53 concomitant AF, admitted between 2022 2023, received NOACs AF management seizure control. A control group cardioembolic stroke, receiving (but without PSE), was matched by age, sex, NIHSS scores ensure comparability. Results: Over 24 months, 16 15 experienced new embolic events, no significant difference groups (p = 0.82). Seizure improved significantly group, reduced frequency severity. No severe adverse events from were observed. Conclusions: The combination a safe effective treatment does not increase risk recurrent ischemic or hemorrhagic events. Further studies larger sample sizes longer follow-ups are needed confirm these findings optimize protocols.

Language: Английский

Latency of poststroke epilepsy can predict drug resistance DOI
Simona Lattanzi, Eugen Trinka, Gianni Turcato

et al.

European Journal of Neurology, Journal Year: 2022, Volume and Issue: 29(8), P. 2481 - 2485

Published: May 18, 2022

The progressive nature of epileptogenesis raises the question whether latent period may already carry information about characteristics subsequent epilepsy. This study aimed to explore time from stroke epilepsy onset was related risk drug resistance in patients with poststroke (PSE).Patients secondary cerebral infarct or spontaneous intracerebral hemorrhage were included. Study outcome occurrence defined as failure adequate trials two tolerated and appropriately chosen used antiseizure medication schedules achieve sustained seizure freedom.One hundred fifty-nine PSE a median follow-up 5 (interquartile range [IQR] = 3-9) years In cohort, 29 (18.2%) participants resistant. length interval between 13 (IQR 7-15) months drug-resistant 19 14-42) (p < 0.001) control. According multivariable regression analysis, an independent predictor 0.001). highest when occurred within first decreased progressively steeper decline over 12 months.Substantial variability exist pathways leading distinguish variable resistance.

Language: Английский

Citations

20
Incidence and predictors of post stroke seizure among adult stroke patients admitted at Felege Hiwot compressive specialized hospital, Bahir Dar, North West Ethiopia, 2021: a retrospective follow up study DOI Creative Commons

Tadios Lidetu,

Dagmawit Zewdu

BMC Neurology, Journal Year: 2023, Volume and Issue: 23(1)

Published: Jan. 25, 2023

A post stroke seizure is a period of neurological dysfunction caused by abnormal neuronal activity. Seizures after have an impact on patients' lives and increase mortality in patients. It also has negative the prognosis stroke. However, there scarcity literature Ethiopia occurrence post-stroke seizures. Therefore, this study aimed to assess incidence predictors at Felege Hiwot compressive specialized hospital, North West Ethiopia.An institution-based retrospective follow-up was carried out Compressive Specialized Hospital, from July 1, 2017 June 30, 2021. The records 568 patients were reviewed using random sample method. To find seizures, we applied log-binomial regression model.The seizures 22.18%( 95% CI 18.83%-25.83%). Older age group (ARR = 2.49, 1.33-4.69), hemorrhagic 1.99, 1.25-3.17), surgical intervention 1.85, 1.22-2.81), tramadol medication 1.22-2.81) found be seizure.This revealed that high older age, haemorrhagic type stroke, management, use anti-pain are risk factors for health care professionals must pay special attention provide clinical who seizure.

Language: Английский

Citations

11
Update on first unprovoked seizure in children and adults: A narrative review DOI Creative Commons

María José Jimenez-Villegas,

Lucas Lozano-García,

Jaime Carrizosa

et al.

Seizure, Journal Year: 2021, Volume and Issue: 90, P. 28 - 33

Published: March 30, 2021

Language: Английский

Citations

25
An automatic deep-learning approach for the prediction of post-stroke epilepsy after an initial intracerebral hemorrhage based on non-contrast computed tomography imaging DOI
Ziyi Wang, Haoli Xu, Jiachang Liu

et al.

Quantitative Imaging in Medicine and Surgery, Journal Year: 2025, Volume and Issue: 15(2), P. 1175 - 1189

Published: Jan. 24, 2025

Post-stroke epilepsy (PSE) is a common and significant complication that often occurs after stroke, affects patients' prognosis overall quality of life. In recent years, non-contrast computed tomography (NCCT) has become the preferred method for clinical diagnosis intracerebral hemorrhage (ICH). This study aimed to develop validate triple deep-learning model, simply named, post-stroke network (PSENet), predict PSE in ICH patients based on NCCT. A total 1,130 (62 with 1,068 without PSE) who experienced an initial at our hospital were enrolled this study. Using five-fold cross-validation, all randomly divided into training validation sets ratio 4:1. Next, no-new-Net (nnU-Net) was used automatically segment subsequent quantitative analysis. model developed extract PSE-related features incorporate related cortical involvement (FCI) volume PSE. compared three models constructed using random forest. Model performance mainly evaluated area under curve (AUC). The nnU-Net had high Dice score 0.923. proposed PSENet, which incorporated multiple features, showed excellent diagnostic performance, accuracy 0.876, F1-score 0.621, recall 0.716, specificity 0.897, AUC 0.840, significantly surpassed baseline (AUC =0.787). Based findings, PSENet could be quickly first ICH, especially scenarios reliable information lacking admission.

Language: Английский

Citations

0
Clinical significance of GABA, NSE, and miR-155 expression in patients with post-stroke epilepsy DOI
Peng Wang, Jiankang Huang, Hongbo Wen

et al.

Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Research Progress of Post-Stroke Epilepsy: Pathophysiology, Diagnosis, Treatment and Prognosis DOI

丹丹 田

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(03), P. 174 - 183

Published: Jan. 1, 2025

Language: Английский

Citations

0
Altered intrinsic thalamic network based on electroencephalography source-level analysis in poststroke epilepsy DOI Creative Commons

Dong Ah Lee,

Junghae Ko, Bong Soo Park

et al.

Medicine, Journal Year: 2025, Volume and Issue: 104(12), P. e41886 - e41886

Published: March 21, 2025

This study aimed to investigate the alterations in intrinsic thalamic network patients with poststroke epilepsy (PSE) based on electroencephalography (EEG) source-level analysis. retrospective observational followed STROBE guidelines. Thirty-nine stroke and PSE 34 without were enrolled. These underwent EEG a resting state. Source localization scalp electrical potentials was computed using minimum norm imaging method standardized low-resolution brain electromagnetic tomography approach. To construct functional connectivity matrix, Talairach atlas used define nodes belonging thalamus, coherence applied measure synchronization as edges. The analyzed graph theory compared between PSE. analysis revealed notable differences From undirected weighted of modularity lower than those (0.038 vs 0.106, P = .024). Additionally, measures showed significant groups, demonstrated by theoretical binary graphs fixed density range connections. is first demonstrate changes may be related development.

Language: Английский

Citations

0
Risk of Poststroke Epilepsy Among Young Adults With Ischemic Stroke or Intracerebral Hemorrhage DOI
Esmée Verburgt,

Lina Fellah,

Merel S. Ekker

et al.

JAMA Neurology, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Importance Poststroke epilepsy (PSE) is a major complication among young adults and associated with problems functional recovery daily life. Although scores have been developed to predict risk of PSE, they not validated patients stroke at age. Objectives To investigate both the factors for PSE age validate current cohort adults. Design, Setting, Participants This study used data from ODYSSEY (Observational Dutch Young Symptomatic Stroke Study), prospective conducted 17 hospitals in Netherlands between May 27, 2013, March 3, 2021, follow-up until February 28, 2024. included 1388 consecutive aged 18 49 years neuroimaging-proven ischemic or intracerebral hemorrhage (ICH) without history epilepsy. Statistical analysis took place June August Exposure First-ever ICH. Main Outcomes Measures was defined as least 1 remote symptomatic seizure (&amp;gt;7 days). Cumulative incidence functions were calculate 5-year PSE. Fine-Gray regression models identify (age, sex, clinical stroke, neuroimaging variables). The performances SeLECT (severity large-artery atherosclerosis, early seizure, cortical involvement, territory middle cerebral artery) 2.0 score (for stroke) CAVE (cortical age, bleeding volume, seizure) ICH) assessed C statistics calibration bar plots. Results (ischemic 1231 [88.7%]; ICH, 157 [11.3%]; median 44.1 [IQR, 38.0-47.4 years]; 736 men [53.0%]; follow-up, 5.3 3.4-7.4 years]), whom 57 (4.1%) cumulative 3.7% (95% CI, 0.2%-4.8%) after 7.6% 3.5%-11.8%) Factors an acute (&amp;lt;7 days) (hazard ratio [HR], 10.83 [95% 2.05-57.07]; P = .005) involvement (HR, 5.35 1.85-15.49]; .002). only factor ICH 8.20 2.22-30.25]; statistic 0.78 0.71-0.84) 0.83 0.76-0.90) score, good scores. Conclusion suggests that relatively low similar variables existing scores, which can therefore also be applied stroke. Future trials should optimal primary secondary prophylaxis high risk.

Language: Английский

Citations

0
Exploring the Association Between Aging, Ferroptosis, and Common Age-Related Diseases DOI

Laleh Mavaddatiyan,

Saghi Hakimi Naeini,

Sara Khodabandeh

et al.

Archives of Gerontology and Geriatrics, Journal Year: 2025, Volume and Issue: 135, P. 105877 - 105877

Published: April 28, 2025

Language: Английский

Citations

0
Association of Age and Gender with Early Onset Seizures in Patients of Acute Ischemic Stroke at a Tertiary Care Setting DOI
Rekha Kumari, Atif Ahmed,

Ramesh Kumar Suthar

et al.

Pakistan Journal of Health Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 49 - 52

Published: April 30, 2025

The prevalence of ischemic stroke is more in south Asian countries. Individuals having an early seizure have a significantly elevated chance developing epilepsy after than individuals but no seizure. seizures that occur following the has been observed as contributing to worse outcomes and disabilities. Objective: To determine association age gender with earliest inception sufferers acute at tertiary care setting Sindh Pakistan. Methods: This cross sectional study was organized Department Medicine Bilawal Medical College Hospital, Kotri from 26 May 2023 October 2023. In this study, patients attending Hospital reporting were recruited for research study. presence or absence dependent variable while, age, sociodemographic status are variables present data analyzed on International Bussiness Machine Statistical Package Social Sciences Version 26.0. Results: Out 118 patients, 17 (14.4%) found seizures. appeared significant onset p value 0.01 0.04 correspondingly. Conclusions: It concluded male all aged between 51 60 years likely experience After stroke, could not resemble unfavorable functional prognosis.

Language: Английский

Citations

0