Intervertebral Disc Degeneration and Regeneration: New Molecular Mechanisms and Therapeutics: Obstacles and Potential Breakthrough Technologies

Cells, Journal Year: 2024, Volume and Issue: 13(24), P. 2103 - 2103

Published: Dec. 19, 2024

Pain and disability secondary to degenerative disc disease continue burden the healthcare system, creating an urgent need for effective, disease-modifying therapies. Contemporary research has identified potential therapies that include protein-, cellular- and/or matrix-related approaches; however, none have yet achieved a meaningful clinical impact. The tissue-specific realities of intervertebral create considerable therapeutic challenges due disc’s location, compartmentalization, hypovascularization delicate physiological environment. Furthermore, imaging modalities currently used in practice are largely unable accurately identify sources pain ostensibly discogenic origin. These obstacles considerable; recent begun shed light on possible breakthrough technologies. Such breakthroughs revolutionary better tissue pain. novel molecular been shown be able mediate progression some large animal studies, even provide insight into suppressing development technologies translated use.

Language: Английский

Occupational therapy‐based rehabilitation of sciatic nerve pain

Brain‐X, Journal Year: 2024, Volume and Issue: 2(4)

Published: Dec. 1, 2024

Abstract Sciatica is a severe form of pain caused by compression the sciatic nerve that radiates from back toward hip and outer side leg. Conventional treatments for sciatica include medication, physical therapy, surgery in cases. However, these approaches can be invasive costly may not provide long‐term relief. Occupational therapy refers to intentional strategic application various activities associated with daily life, work, education, leisure address functional impairments. Focusing on targeted exercises, manual techniques, ergonomic modifications alleviate symptoms improve function, it offers promising alternative medical treatments. interventions reduce pain, increase mobility, enhance overall quality life. As an empowering approach, such techniques aid symptom management independence. This article explores occupational therapy‐based assessments, interventions, outcomes, progress tracking, pharmacotherapy, challenges owing surgical approaches, devices rehabilitation, assessments aimed at improving life individuals affected this condition. Future research should focus developing validating new assessment tools outcome measures specific sciatica, enabling more accurate evaluation monitoring.

Language: Английский