Elsevier eBooks, Journal Year: 2023, Volume and Issue: unknown, P. 322 - 334
Published: Dec. 9, 2023
Language: Английский
Quality in Sport, Journal Year: 2025, Volume and Issue: 37, P. 57420 - 57420
Published: Jan. 14, 2025
Introduction and Purpose. Diabetes, characterized by hyperglycemia due to impaired insulin production or action, leads significant complications like diabetic retinopathy (DR) foot syndrome (DFS). Current treatments manage symptoms but do not fully address disease progression. Stem cells, with their regenerative potential immunomodulatory properties, represent a promising avenue for treating diabetes its complications. This study explores the use of stem cell therapy in managing type 1 2 diabetes, DR, DFS. Material Method. The reviewed existing literature on application cells treatment. More than 30 articles addressing these issues were analyzed. They found using PubMed search engine, time frame publications covered last 20 years. Results. demonstrated management. For MSCs reduced inflammation, preserved pancreatic islet function, decreased requirements without major adverse effects. Pluripotent showed promise transplantation, achieving stable glycemic control clinical trials. In improved sensitivity dependency, evidence β-cell regeneration. Complications ulcers also responded positively treatments. wound healing enhancing tissue regeneration reducing while retinal therapies slowing progression repairing damaged vasculature. Conclusions. offer approach complications, particularly applications DR While initial results are encouraging, further large-scale studies needed optimize protocols, assess long-term safety, establish standardized applications.
Language: Английский
Citations
0
Diagnostics, Journal Year: 2025, Volume and Issue: 15(6), P. 651 - 651
Published: March 7, 2025
Glucose is the main source of energy in human cells. Elevated levels glucose are one most common metabolic disorders, and it has been shown to have a significant, mostly negative, effect on multiple chronic acute diseases. Lung cancer remains biggest challenges for treatment modern medicine, with high prevalence, incidence mortality. Hyperglycemia not uncommon patients lung cancer; however, usually overlooked. Patients unregulated glycemia worse outcomes, reduced therapeutic more complications during treatment. Studies identified molecular pathways both hyperglycemia no clear correlation identified. By understanding these signaling pathways, we can influence outcome therapeutically thereby improve survival cancer.
Language: Английский
Citations
0
Trends in Sciences, Journal Year: 2024, Volume and Issue: 21(5), P. 7278 - 7278
Published: March 1, 2024
Introduction: Type 2 diabetes mellitus (T2DM) is a prevalent form of that affects 90 - 95 % all diabetic patients. Insulin sensitizers and insulin exogenous supply could temporarily ameliorate hyperglycaemia; however, they are accompanied by side effects. As result, new approaches required to address resistance regenerate beta cells simultaneously. The secretome hypoxic mesenchymal stem (SH-MSCs) contains various growth factors anti-inflammatory cytokines potentially enhance improve pancreatic function. Objectives: In this study, we performed SH-MSCs infusion HFD-induced hyperglycaemia in T2DM rats. Methods: We created rat model using combination high-fat diet (HFD) streptozotocin (STZ) administration. Then, administered injection at doses 250 500 µL assessed the therapeutic effects SH-MSCs. also investigated potential underlying mechanisms involved. Results: administration improved hyperglycemia rats with T2DM. Infusion dose decreased homeostatic assessment for (HOMA-IR). Histological analysis revealed alleviated morphological damage pancreas. inhibit level IL-6 promote expression CD163 type macrophage. Conclusion: results our study indicate have exert protective effect on HIGHLIGHTS Administration effectively TD2M through modulation levels promotes macrophage demonstrated morphology hold promise improving hyperglycemia, resistance, providing GRAPHICAL ABSTRACT
Language: Английский
Citations
0
Archives of Medical Science, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 30, 2024
Introduction Mesenchymal stem cells (MSCs) have promising regenerative properties in tissue repair and anti-inflammatory responses. This study aimed to investigate the effects of MSCs their combination with micronized purified flavonoid fraction (MPFF) a croton oil-induced hemorrhoids model on edema, inflammation, underlying molecular mechanisms. Material methods were isolated characterized for adherence, differentiation capacity, immunophenotyping. Croton hemorrhoid mouse models established assess tumor necrosis factor (TNF-α) expression, transforming growth factor-β (TGF-β) collagen ratio, MMP-9 activity. The MPFF (diosmin-hesperidin) evaluated through histological examinations, western blot analysis, gelatin zymography. Results Characterization confirmed MSCs’ plastic osteogenic potential, immunophenotype (positive CD90 CD29, negative CD45 CD31). Treatment alone or significantly reduced TNF-α Additionally, increased TGF-β type I/III accelerated wound healing by resolving inflammation. Conclusions These findings suggest that play crucial role modulating TNF-α, TGF-β, remodeling, activity, highlighting treatment processes. Further research is warranted fully elucidate intricate mechanisms optimize MSC-based therapies clinical applications hemorrhoidal disease management.
Language: Английский
Citations
0
Elsevier eBooks, Journal Year: 2023, Volume and Issue: unknown, P. 322 - 334
Published: Dec. 9, 2023
Language: Английский
Citations
0