Evaluation of serotonin levels in full-term newborns of diabetic mothers
Journal of obstetrics and women s diseases,
Journal Year:
2024,
Volume and Issue:
73(1), P. 41 - 50
Published: March 26, 2024
BACKGROUND:
The
growth
of
neurological
and
mental
diseases
in
the
offspring
patients
with
pre-
gestational
diabetes
mellitus
determines
need
to
study
regulatory
function
serotoninergic
system
brain
newborns.
This
plays
a
key
role
its
morphofunctional
development
early
ontogenesis,
which
is
necessary
for
timely
diagnosis
disorders
prevention
long-term
consequences.
AIM:
aim
this
was
evaluate
serotonin
levels
full-term
newborns
diabetic
fetopathy
from
mothers
mellitus.
MATERIALS
AND
METHODS:
main
group
consisted
45
fetopathy,
whom
30
individuals
were
type
1
15
ones
mellitus.
control
comprised
20
healthy
without
pregnancy
complications.
Serotonin
concentrations
determined
platelet-rich
plasma
blood
umbilical
cord
vein,
platelet
suspension
prepared
venous
taken
on
first
day
life,
using
high-performance
liquid
chromatography
electrochemical
detection.
RESULTS:
Platelet-rich
level
more
than
two
times
lower
compared
children
mothers.
parameter
(0.744
±
0.117
µmol/l)
corresponded
that
patients,
while
mellitus,
it
significantly
amounted
0.331
0.071
µmol/l
(p
0.05).
Moreover,
all
correlated
their
(R
=
0.505;
p
platelets
almost
2.5
ones.
CONCLUSIONS:
data
obtained
indicate
use
values
as
biochemical
marker
functional
fetopathy.
Language: Английский
The role of serotonin in prenatal ontogenesis
Journal of obstetrics and women s diseases,
Journal Year:
2023,
Volume and Issue:
72(4), P. 81 - 92
Published: Sept. 28, 2023
This
review
article
summarizes
current
ideas
about
the
role
of
serotonin
in
prenatal
ontogenesis.
We
herein
present
results
experimental
and
clinical
studies
that
reveal
mechanisms
involvement
establishment
development
single
mother-placenta-fetus
system.
The
highlights
key
maternal
genetic
program
for
morphological
functional
fetal
organs
from
earliest
stages
ontogenesis,
both
normal
complicated
pregnancy.
also
discuss
gestational
factors
affect
production
maternal,
placental,
serotonin,
as
its
deficiency
or
excess
during
pregnancy
determines
perinatal
long-term
pathology
programming
offspring.
substantiates
prospects
using
a
biochemical
marker
brain
damage
newborn
timely
application
neuroprotection
prevention
adverse
consequences.
Language: Английский