Critical Review on Anti-Obesity Effects of Anthocyanins Through PI3K/Akt Signaling Pathways DOI Open Access
Nidesha Randeni, Jinhai Luo, Baojun Xu

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(7), P. 1126 - 1126

Published: March 24, 2025

Obesity is a global health crisis and one of the major reasons for rising prevalence metabolic disorders such as type 2 diabetes, cardiovascular diseases, certain cancers. There has been growing interest in search natural molecules with potential anti-obesity effects; among phytochemicals are anthocyanins, which flavonoid pigments present many fruits vegetables. Anthocyanins influence obesity via several signaling pathways. The PI3K/Akt pathway plays role focus on downstream targets GLUT4, FOXO, GSK3β, mTOR, play central regulation glucose metabolism, lipid storage, adipogenesis. critical factors oxidative stress inflammation also affect pathophysiology obesity. However, studies reviewed have limitations, including variations experimental models, bioavailability challenges, lack extensive clinical validation. While anthocyanin shows tremendous potential, challenges poor bioavailability, stability, regulatory matters must be overcome successful functional food inclusion anthocyanins. future anthocyanin-derived foods lies their ability to hurdles. Therefore, this review highlights molecular mechanisms through pathways explores how anthocyanins can modulate these address related disorders. It addresses some ways solve like while emphasizing possibilities anthocyanin-based management.

Language: Английский

Critical Review on Anti-Obesity Effects of Anthocyanins Through PI3K/Akt Signaling Pathways DOI Open Access
Nidesha Randeni, Jinhai Luo, Baojun Xu

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(7), P. 1126 - 1126

Published: March 24, 2025

Obesity is a global health crisis and one of the major reasons for rising prevalence metabolic disorders such as type 2 diabetes, cardiovascular diseases, certain cancers. There has been growing interest in search natural molecules with potential anti-obesity effects; among phytochemicals are anthocyanins, which flavonoid pigments present many fruits vegetables. Anthocyanins influence obesity via several signaling pathways. The PI3K/Akt pathway plays role focus on downstream targets GLUT4, FOXO, GSK3β, mTOR, play central regulation glucose metabolism, lipid storage, adipogenesis. critical factors oxidative stress inflammation also affect pathophysiology obesity. However, studies reviewed have limitations, including variations experimental models, bioavailability challenges, lack extensive clinical validation. While anthocyanin shows tremendous potential, challenges poor bioavailability, stability, regulatory matters must be overcome successful functional food inclusion anthocyanins. future anthocyanin-derived foods lies their ability to hurdles. Therefore, this review highlights molecular mechanisms through pathways explores how anthocyanins can modulate these address related disorders. It addresses some ways solve like while emphasizing possibilities anthocyanin-based management.

Language: Английский

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