Structural brain preservation: a potential bridge to future medical technologies

Frontiers in Medical Technology, Journal Year: 2024, Volume and Issue: 6

Published: Sept. 9, 2024

When faced with the prospect of death, some people would prefer a form long-term preservation that may allow them to be restored healthy life in future, if technology ever develops point this is feasible and humane. Some believe we have capacity perform type experimental today-although it has never been proven-using contemporary methods preserve structure brain. The idea morphomolecular organization brain encodes information required for psychological properties such as personality memories. If these structures can maintained intact over time, could theoretically provide bridge access restorative technologies future. To consider hypothesis, first describe possible metrics used assess structural quality. We next explore several brain, including traditional cryonics method cryopreservation, well aldehyde-stabilized cryopreservation fluid preservation. focus in-depth on preservation, which relies aldehyde fixation induce chemical gel formation wide set biomolecules appears cost-effective method. two theoretical recovery technologies, alongside ethical legal complexities all will require prudent approach. non-negligible chance allowing successful restoration future deserves serious research efforts by scientific community.

Language: Английский

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How to remove the brain of Amazonian manatee (Trichechus inunguis) calves preserving the skull for morphological analysis

Acta Amazonica, Journal Year: 2025, Volume and Issue: 55

Published: Jan. 1, 2025

ABSTRACT Although there are several studies on the skull of Amazonian manatees (Trichechus inunguis) to better understand anatomy, physiology, and behavior these animals, analysis brain has been often neglected. Typically, in osteological studies, is discarded preserve integrity skull. One main reasons for this neglect lack adequate dissection protocols allow extraction intact while preserving In study, we present a simple step-by-step protocol comprehensive procedure fixation manatee calves ensuring preservation structure best possible extent further studies. The based an incision at posterior part skull, extending laterally toward parietal bone until reaching frontal bone, followed by removing upper portion skullcap extract brain. After procedure, removed can be reconstituted entire structure. also offers adaptations simplify methodology according reality places with little laboratory structure, allowing rare tissues limited resources and/or areas difficult access. Our proposed enables maximum utilization collected animal, which not only aligns ethical practical considerations, but makes material available detailed description brain, understanding neuroanatomy aquatic mammals general.

Language: Английский

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Developing an inclusive and transparent structural brain preservation program

Published: May 9, 2024

Oregon Brain Preservation, a Non-Profit Mutual Benefit corporation, is launching new program to make structural brain preservation services more accessible and transparent. The aims reduce financial logistical barriers while providing transparent quality assessments through microscopy studies of biopsy samples. procedure involves aldehyde fixatives followed by long-term fluid preservation. will cover Oregon, Washington, Northern California, with plans expand geographically if we are able secure additional philanthropic support. Research focus on evaluating macroscopic examination, neuroimaging experiments, microscopic currently funded philanthropy, the goal continuing this funding model long-term. Interested individuals can sign up reviewing signing paperwork available our website. We invite feedback, collaboration, support in attempt advance field it all.

Language: Английский

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Biostasis: A Roadmap for Research in Preservation and Potential Revival of Humans

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(9), P. 942 - 942

Published: Sept. 21, 2024

Human biostasis, the preservation of a human when all other contemporary options for extension quality life are exhausted, offers speculative potential survival via continuation in future. While provably reversible preservation, also known as suspended animation, is not yet possible humans, primary justification biostasis brain, which broadly considered seat memories, personality, and identity. By preserving information contained within brain’s structures, it may be to resuscitate healthy whole individual using advanced future technologies. There numerous challenges including inadequacies current techniques, methods evaluate revival In this report, we describe roadmap that attempts delineate research directions could improve field focusing on optimizing protocols establishing metrics querying quality, well pre- post-cardiac arrest factors, stabilization strategies, long-term preservation. We acknowledge highly theoretical nature technologies importance achieving high-fidelity brain maximize repair plan update biennially. Our goal encourage multidisciplinary communication collaboration field.

Language: Английский

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