Systematic revelation and meditation on the significance of long exons using representative eukaryotic genomes DOI Creative Commons
Yuange Duan, Qi Cao

BMC Genomics, Journal Year: 2025, Volume and Issue: 26(1)

Published: March 24, 2025

Long exons/introns are not evenly distributed in the genome, but biological significance of this phenomenon remains elusive. Exon properties were analyzed seven well-annotated reference genomes, including human and other representative model organisms: mouse, fruitfly, worm, mouse-ear cress, corn, rice. In all species, last exons genes tend to be longest. Additionally, we found that (1) canonical splicing motifs strongly underrepresented 3'UTR; (2) Last have low GC content; (3) Comparing with first D. melanogaster demonstrate lower content than internal exons. It cannot excluded exert essential regulatory roles is subjected natural selection, exhibiting differential tendency, compared parts gene body.

Language: Английский

Systematic revelation and meditation on the significance of long exons using representative eukaryotic genomes DOI Creative Commons
Yuange Duan, Qi Cao

BMC Genomics, Journal Year: 2025, Volume and Issue: 26(1)

Published: March 24, 2025

Long exons/introns are not evenly distributed in the genome, but biological significance of this phenomenon remains elusive. Exon properties were analyzed seven well-annotated reference genomes, including human and other representative model organisms: mouse, fruitfly, worm, mouse-ear cress, corn, rice. In all species, last exons genes tend to be longest. Additionally, we found that (1) canonical splicing motifs strongly underrepresented 3'UTR; (2) Last have low GC content; (3) Comparing with first D. melanogaster demonstrate lower content than internal exons. It cannot excluded exert essential regulatory roles is subjected natural selection, exhibiting differential tendency, compared parts gene body.

Language: Английский

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