EXTRACELLULAR MATRIX OF EXPERIMENTAL HEPATOCARCINOMA G-29 UNDER THE INFLUENCE OF LITHIUM CARBONATE DOI Open Access

V.V. Makarova,

N.P. Bgatova

Cardiometry, Journal Year: 2022, Volume and Issue: 24, P. 47 - 48

Published: Nov. 30, 2022

Hepatocellular carcinoma (HCC) is one of the most aggressive human tumors with a high mortality rate. Despite fact that incidence rate this sort high, mechanisms its pathogenesis and metastasis are not fully understood, existing therapy often unsuccessful. There evidence in reference literature available patients HCC, alterations occur microenvironment tumor tissue, including extracellular matrix (ECM) stimulates growth HCC cells. Therefore, aim our study was to investigate state ECM during spontaneous development lithium carbonate introduction.

Language: Английский

GENOME-WIDE ANALYSIS OF TRIPLE-NEGATIVE PHENOTYPE BREAST TUMORS DOI Open Access

М.K. Ibragimova,

M.M. Tsyganov,

N.V. Litvyakov

et al.

Cardiometry, Journal Year: 2022, Volume and Issue: 24, P. 58 - 60

Published: Nov. 30, 2022

Identification of the molecular genetic phenotype breast carcinomas is an important prognostic factor disease, and helps to personalize treatment such patients. According evidence data from reference literature, cancer (BC) with a triple negative among all subtypes accounts for about 10-24%, showing most aggressive progression and, as result, has worst prognosis.

Language: Английский

Citations

38
ACCOMPANYING TRANSCRANIAL MAGNETOTHERAPY IN COMBINATION TREATMENT OF HIGH-GRADE GLIAL BRAIN TUMORS DOI Open Access

I.A. Popov,

A.I. Shikhlyarova,

E.M. Frantsiyants

et al.

Cardiometry, Journal Year: 2022, Volume and Issue: 24, P. 56 - 58

Published: Nov. 30, 2022

Low survival and poor quality of life in patients with high-grade brain gliomas (HGG) dictate the need to develop promote new approaches, including accompanying transcranial magnetic therapy (TMT) pulse-type field (PT MF) ultra-low-frequency fields (ULF MF), characterized by their non-invasiveness safety applied procedures. The key point these original wave technologies is construction algorithms actions based on principles activation therapy, which was developed as a result discovery “Pattern development qualitatively differing general nonspecific adaptational reactions organism” (Scientific Discovery Registration Certificate No. 158 issued Committee Inventions Discoveries at Council Ministers USSR, 1975).

Language: Английский

Citations

38
GD2-SPECIFIC CAR-T CELLS CO-EXPRESSING THE IL15 MEMBRANE FORM EFFECTIVELY LYSE GD2-POSITIVE CELL TARGETS DOI Open Access

M.D. Mollaev,

P.N. Vikhreva,

A.V. Kibardin

et al.

Cardiometry, Journal Year: 2022, Volume and Issue: 24, P. 26 - 27

Published: Nov. 30, 2022

Genetically modified T cells expressing chimeric receptors (CAR-T) have become an important tool for the treatment of CD19+ hematological tumors. Due to a single-chain variable fragment antibody as part CAR receptor, acquire their specificity against selected tumorassociated antigens. The 3rd generation also includes transmembrane, co-stimulatory domains, and tyrosine activation motifs derived from CD3z.

Language: Английский

Citations

38
STUDY OF BIOLOGICAL ACTIVITY OF DOXORUBICIN CONJUGATE WITH NACETYL-D-GALACTOSAMINE HYDRASONIC LINKER DOI Open Access

Anna S. Pestretsova,

D.V. Kozina,

D.V. Sokolova

et al.

Cardiometry, Journal Year: 2022, Volume and Issue: 24, P. 36 - 37

Published: Nov. 30, 2022

Molecules containing the N-acetylgalactosamine residue are capable to bind asialoglycoprotein receptor, a protein presented on surface of liver tumor cells; therefore it is suggested that doxorubicin conjugates such fragment can be delivered hepatocellular carcinoma cells as target, and then, upon hydrazone link splitting, in acidic environment release active substance.

Language: Английский

Citations

38
INFLUENCE OF HYPOTHYROIDISM ON THE HYPOTHALAMIC-PITUITARYGONADAL AXIS IN RATS WITH GUERIN'S TUMOR DOI Open Access

E.M. Frantsiyants,

V.A. Bandovkina,

I.V. Kaplieva

et al.

Cardiometry, Journal Year: 2022, Volume and Issue: 24, P. 48 - 49

Published: Nov. 30, 2022

The thyroid and the gonadal (HPG) regulatory axes are interconnected act together as a single system their imbalance leads to pathological responses of organism [1, 2]. involvement sex hormones in development malignant process has been discussed for many decades.

Language: Английский

Citations

38
INNOVATIVE APPROACHES TO DEVELOPMENT OF GEROPROTECTORS-PHYTOADAPTOGENS FOR PREVENTIVE ONCOLOGY AND AGE-RELATED PATHOLOGIES DOI Open Access

O.A. Bocharova,

R.V. Karpova,

E.V. Bocharov

et al.

Cardiometry, Journal Year: 2022, Volume and Issue: 24, P. 35 - 36

Published: Nov. 30, 2022

At the present stage, problems of preventive oncology are becoming more and important, especially, at stages blastomogenesis, recurrence metastasizing tumors. Preventive measures can also be aimed regulating stress syndrome, improving efficiency safety chemoradiotherapy, quality life rehabilitation processes for cancer patients. Promising in this aspect approaches, which take into account unique capabilities natural antitumor geroprotectors: phytoadaptogens (PhA).

Language: Английский

Citations

1
PERSONALIZED APPROACH TO ADJUVANT CHEMOTHERAPY IN PATIENTS WITH NON-SMALL CELL LUNG CANCER DOI Open Access

M.M. Tsyganov,

E.O. Rodionov,

М.K. Ibragimova

et al.

Cardiometry, Journal Year: 2022, Volume and Issue: 24, P. 60 - 61

Published: Nov. 30, 2022

Numerous studies have shown that differential expression and/or co-expression of several chemosensitivity genes, such as ERCC1, RRM1, TUBB3, TOP2A, and some others, in the tumor tissue are closely associated with chemoresistance prognosis cancer patients. Despite fact more data comes to support idea on important role presented genes assessment (CS), at present time there is ample room remaining for further research combined estimation CS gene a personalized approach chemotherapy patients lung cancer.

Language: Английский

Citations

0
ANTIBODY-FREE CHIMERIC FLT3-CAR RECEPTOR FOR TARGETING THE FLT3 RECEPTOR, A MARKER OF POOR PROGNOSIS IN ACUTE MYELOID LEUKEMIA DOI Open Access

V.E. Mayorova,

M.D. Mollaev,

P.N. Vikhreva

et al.

Cardiometry, Journal Year: 2022, Volume and Issue: 24, P. 63 - 65

Published: Nov. 30, 2022

Therapy in acute myeloid leukemia (AML) usually begins with a course of induction chemotherapy using anthracyclines and cytarabine to eliminate blast cells. Chemotherapy is necessary step preparing patient for transplantation donor hematopoietic stem cells (HSCs). However, often show their chemoresistance initiate the AML recurrence. Specific elimination leukemic during preparation HSC may reduce probability For this purpose, an active development chimeric antigen receptors (CAR) address various markers being progress.

Language: Английский

Citations

0
ANALYSIS OF IMMUNOHISTOCHEMICAL REACTIONS OF VARIOUS PD-L1 CLONES IN PROSTATE ADENOCARCINOMA DOI Open Access

M.A. Kalfa,

E.P. Golubinskaya,

T.P. Makalish

et al.

Cardiometry, Journal Year: 2022, Volume and Issue: 24, P. 68 - 69

Published: Nov. 30, 2022

Prostate cancer (PC) is the most commonly diagnosed malignancy in men. The standard treatment for localized PC radical prostatectomy, but recurrence a significant problem this case. main prognostic markers of disease are Gleason score and preoperative level prostate-specific antigen (PSA), which determines need to identify some key molecules progression. This can be useful identifying new or targeted treatments pathology.

Language: Английский

Citations

0
PECULIARITIES OF INFLUENCE MADE BY DIABETES MELLITUS AS COMORBID PATHOLOGY ON THE SYSTEM OF SEX HORMONES AND THEIR RECEPTORS IN TUMORS OF DIFFERENT HISTOLOGICAL ORIGIN DOI Open Access
E. M. Frantsiyants, Е. И. Сурикова,

V.A. Bandovkina

et al.

Cardiometry, Journal Year: 2022, Volume and Issue: 24, P. 52 - 54

Published: Nov. 30, 2022

Improving the survival of cancer patients contributes to a growing number with chronic comorbidities, including diabetes mellitus (DM). Moreover, higher risk development in DM and poor prognosis determine importance studying mechanisms mediating effect altered glucose metabolism made on growth metastasis malignant tumors [3,4]. The polyetiology both pathologies presence research studies that do not confirm direct relationship between neoplasms indicate complex nature their possible context-dependent regulation many cellular processes associated carcinogenesis [1,2]. An important role is played by an imbalance system sex hormones.

Language: Английский

Citations

0