Advances in myopia control strategies for children

British Journal of Ophthalmology, Journal Year: 2024, Volume and Issue: unknown, P. bjo - 323887

Published: May 22, 2024

Myopia has long been a global threat to public health. Timely interventions are likely reduce the risk of vision-threatening complications. There both established and rapidly evolving therapeutic approaches slow myopia progression and/or delay its onset. The effective methods for slowing include atropine eye-drops, defocus incorporated multiple segments (DIMS) spectacle lenses, lenses with highly aspherical lenslets target (HALT), diffusion optics technology (DOT) red light therapy (RLT), multifocal soft contact orthokeratology. Among these, 0.05% atropine, HALT RLT +3.00 peripheral addition yield over 60% reduction in progression, whereas DIMS, DOT MiSight demonstrate at least 50% control efficacy. demonstrates more optimal balance efficacy safety than 0.01%. 0.01% not consistent requires further validation across diverse ethnicities. Combining orthokeratology or DIMS spectacles yields better outcomes using these as monotherapies. Increased outdoor time is an health strategy prevention while recent studies suggest that low-concentration have promising potential clinical high-risk groups. being invasive, safe long-term use. However, when considering other approaches, it essential ensure proper instruction regular follow-ups maintain monitor any Ultimately, significant advances made strategies, many which shown meaningful outcomes. use adequate monitoring extended durations imperative foster confidence can only come from extensive experience.

Language: Английский

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Efficacy and factors influencing toric orthokeratology lenses in managing moderate to high astigmatic myopia

Optometry and Vision Science, Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

SIGNIFICANCE: Toric orthokeratology lenses show potential in slowing myopia progression adolescents with moderate to high astigmatic myopia. These findings support the broader application of toric managing challenging refractive conditions and mitigating myopia-related complications. PURPOSE: This study seeks probe efficacy controlling analyze risk factors influencing treatment outcomes. METHODS: One hundred adolescent patients who were treated at our medical facility from January 2022 2023 randomly selected as subjects. All allocated either experimental group (n = 50) or control using a random number table method. The was subjected spherical lenses, whereas lenses. Changes uncorrected visual acuity, axial length, cylinder diopters, sphere average corneal curvature before after 12 months compared between two groups. logistic regression analysis conducted identify adolescents. RESULTS: Both cohorts showed substantial improvements sphere, their pre-treatment values, cohort showing greater than (p=0.01, 0.03, 0.00, 0.00). There no significant differences groups (p=0.56). Univariate unraveled age, baseline E value, central thickness (p=0.00, 0.04, 0.02, 0.05). Receiver operating characteristic curve displayed that area under for model attained 0.82, 95% confidence interval (0.69, 0.95), sensitivity 88%, specificity 72%, Youden index 0.61. CONCLUSIONS: demonstrate by progression. Patients are older, severely nearsighted, have longer length experience more over

Language: Английский

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The optimal atropine concentration for myopia control in Chinese children: a systematic review and network Meta-analysis

International Journal of Ophthalmology, Journal Year: 2024, Volume and Issue: 17(6), P. 1128 - 1137

Published: May 24, 2024

AIM: To figure out whether various atropine dosages may slow the progression of myopia in Chinese kids and teenagers to determine optimal concentration for effectively slowing myopia. METHODS: A systematic search was conducted across Cochrane Library, PubMed, Web Science, EMBASE, CNKI, CBM, VIP, Wanfang database, encompassing literature on with varying concentrations from database inception January 17, 2024. Data extraction quality assessment were performed, a network Meta-analysis executed using Stata version 14.0 Software. Results visually represented through graphs. RESULTS: Fourteen papers comprising 2475 cases included; five different solution used. The Meta-analysis, along surface under cumulative ranking curve (SUCRA), showed that 1% (100%)>0.05% (74.9%) >0.025% (51.6%)>0.02% (47.9%)>0.01% (25.6%)>control refraction change (98.7%)>0.05% (70.4%)>0.02% (61.4%)>0.025% (42%)>0.01% (27.4%)>control axial length (AL) change. CONCLUSION: In children teenagers, can reduce Although is best one controlling AL change, there high incidence adverse effects use atropine. Therefore, we suggest 0.05% progression.

Language: Английский

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Impact of multifocal gas-permeable lens designs on short-term choroidal response, axial length, and retinal defocus profile

International Journal of Ophthalmology, Journal Year: 2024, Volume and Issue: 17(2), P. 247 - 256

Published: Jan. 22, 2024

To investigate the impact of multifocal gas permeable contact lens (MFGPCL) in various add power and distance/near area allocation on short-term changes choroidal thickness (ChT), axial length (AL), retinal defocus profile young adults.

Language: Английский

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Factors affecting choroidal circulation parameters in 4–14-year-old Chinese children measured by SS-OCT/OCTA

Photodiagnosis and Photodynamic Therapy, Journal Year: 2024, Volume and Issue: 48, P. 104275 - 104275

Published: July 11, 2024

To measure the choroidal circulatory parameters Han Chinese children aged 4-14 years from Southwest China, and to explore relationships between these age, axial length (AL), thickness (ChT).

Language: Английский

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Effects of atropine on choroidal thickness in myopic children: a meta-analysis

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 21, 2024

Background Atropine is an effective medicine for myopia prevention and control. This meta-analysis was conducted to investigate the effects of atropine on choroidal thickness (ChT) in children with myopia. Methods Between its inception 1 June 2023, Medline, Embase, Web Science were all searched, only English literature included. The primary study outcome. Axial length, standardized equivalent refraction examined as secondary outcomes. STATA 12.0 used data extraction analysis. Results A total 307 eyes involved this evaluate effect ChT, axial length (AL) (SER) myopic children. Choroidal thickening significantly higher group than control at month (WMD, 6.87 mm, 95% CI, 0.04 13.10, P = 0.049), whereas it months 6 10.37 −3.21 23.95, 0.135), 12 15.10 −5.08 35.27, 0.143) final follow-up 11.52 −3.26 26.31, 0.127), differences not statistically significant. At −0.03 −0.04 −0.01, 0.003), −0.07 −0.01 −0.03, 0.000), −0.13mm, −0.15 −0.11, 0.843), −0.08 −0.16 treatment able delay elongation. 1-month follow-up, there no significant difference SER compared 0.01D, progression refractive status 0.127). Conclusion Limited evidence suggests that 0.01% causes treatment. In short term, may be a predictor effectiveness controlling terms AL. Systematic Review Registration http://www.crd.york.ac.uk/prospero , identifier, CRD42022381195.

Language: Английский

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Impact of Myopia Progression and Its Intervention Methods on Choroidal Thickness

Annals of Optometry and Contact Lens, Journal Year: 2024, Volume and Issue: 23(2), P. 51 - 57

Published: June 25, 2024

As the prevalence of myopia has recently increased, there is growing interest in interventions to slow progression. The choroid, rearmost and largest part uveal layer, a tissue rich blood vessels located between retina sclera. Recent advancements diagnostic equipment have enabled direct imaging leading increased research on its role both normal pathological conditions. Regarding myopia, it been reported that; 1) choroidal thickness decreases as degree axial length increase, 2) case moderate high concentrations atropine or orthokeratology lenses, which are known myopic progression, thickening accompanied from early stages application, 3) mechanism by slows progression also being actively investigated. result, choroid recognized therapeutic target for developing new Additionally, increase predictive factor subsequent suggesting potential biomarker assessing likelihood future

Language: Английский

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Changes in choroidal thickness and lamina cribrosa position in subjects with overdipper pattern of arterial pressure

European Journal of Ophthalmology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 15, 2024

Introduction The purpose is to analyze the changes produced in subjects with an overdipper pattern of ambulatory blood pressure monitoring aim understanding pathophysiology normal tension glaucoma. Methods A cross sectional study was performed patients exhibiting and non-overdipper patterns, respectively. Different optic parameters were assessed including analysis ganglion cell layer (GCL), peripapillary retinal nerve fiber (pRNFL) Bruch's membrane opening-minimum rim width (BMO-MRW), as well choroidal thickness (CT) lamina cribrosa (LC) position at two different periods day (early morning evening). Results total 80 eyes (42 38 non-overdipper) analyzed. shortening distance beginning end LC objectified ( p < 0.003) a statistically significant shift between evening measurements 0.023). In addition, thickening found 13 horizontal vertical plane CT 0.029) both groups morning. No differences pRNFL, BMO-MRW GCL measures objectified. Conclusions Morning assessment showed deeper comparison values. increase these subjects. Altogether, findings could illustrate etiopathogenic mechanism damage glaucoma associated pattern.

Language: Английский

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Digital measuring the ocular morphological parameters of guinea pig eye in vivo with Python

International Journal of Ophthalmology, Journal Year: 2024, Volume and Issue: 17(2), P. 239 - 246

Published: Jan. 23, 2024

AIM: To quantitatively measure ocular morphological parameters of guinea pig with Python technology. METHODS: Thirty-six eyeballs eighteen 3-week-old pigs were measured keratometer and photographed to obtain the horizontal, coronal, sagittal planes respectively. The corresponding photo pixels-actual length ratio was acquired by a proportional scale. edge coordinates identified artificially ginput function. Circle conic curve fitting applied fit contour eyeball in sagittal, coronal horizontal view. curvature, curvature radius, eccentricity, tilt angle, corneal diameter, binocular separation angle calculated according geometric principles. Next, removed, canny detection identify vitro. results compared between vivo RESULTS: Regarding radius on planes, no significant differences observed among vivo, vitro, keratometer. vertical angles 130.6°±6.39° 129.8°±9.58° For eccentricity planes. CONCLUSION: Graphical interface window makes up deficiency detection, which requires too much definition Matlab. There are human beings, such as exotropic eye position, oblique oval eyeball, obvious discrepancy binoculus. This study helps evaluate objectively small experimental animals emmetropization research.

Language: Английский

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The citicoline effect of choroidal and scleral thickness in Rattus norvegicus myopia model: A preliminary study

GSC Biological and Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 28(1), P. 262 - 267

Published: July 30, 2024

This preliminary study aim to analyze the effect of citicoline scleral and choroidal thickness in rattus norvegicus myopia model. used lens induced (LIM) method, by giving -10.00 D that framed with rubber ring for 3 weeks. The using ruber as a frame has more complication risk than silicone frame. 300 mg/kgBW treatment group increase posterior segment od thickness. It could be concluded change average novergicus

Language: Английский

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