Acute Invasive Fungal Rhinosinusitis: Insights from a Cohort on Mortality and Surgical Outcomes DOI Creative Commons
António Andrade, P.C. Sousa, João Paulo A. Almeida

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Abstract Background Acute invasive fungal rhinosinusitis (AIFRS) is a rapidly progressive and aggressive infection, primarily affecting immunocompromised patients. This study aims to characterize the clinical microbiological findings assess treatment outcomes in cases with AIFRS. Methods A retrospective observational was conducted between January 2013 July 2024. Patients were included based on histopathological confirmation of infection evidence Data demographics, comorbidities, symptoms, imaging, microbiology, treatment, collected. Results Twelve patients included, mean age 52.3 (± 13.5) years predominance females (9/12). Diabetes mellitus hematologic malignancies most common comorbidities (5 each). The frequent pathogens Aspergillus spp. (6 cases) Mucorales cases). sphenoid ethmoid sinuses commonly affected (10 Orbital invasion cavernous sinus involvement observed 9 4 cases, respectively. Three underwent orbital exenteration survived. Two patients, distinct underlying etiologies pathogens, treated concomitantly hyperbaric oxygen therapy, no reported fatalities. overall mortality rate 58.3%, 41.7% directly attributed Conclusions AIFRS associated high mortality, particularly Establishing standardized surgical criteria essential for improving involving orbit. Additionally, therapy selected different or may contribute improved survival.

Language: Английский

Acute Invasive Fungal Rhinosinusitis: Insights from a Cohort on Mortality and Surgical Outcomes DOI Creative Commons
António Andrade, P.C. Sousa, João Paulo A. Almeida

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Abstract Background Acute invasive fungal rhinosinusitis (AIFRS) is a rapidly progressive and aggressive infection, primarily affecting immunocompromised patients. This study aims to characterize the clinical microbiological findings assess treatment outcomes in cases with AIFRS. Methods A retrospective observational was conducted between January 2013 July 2024. Patients were included based on histopathological confirmation of infection evidence Data demographics, comorbidities, symptoms, imaging, microbiology, treatment, collected. Results Twelve patients included, mean age 52.3 (± 13.5) years predominance females (9/12). Diabetes mellitus hematologic malignancies most common comorbidities (5 each). The frequent pathogens Aspergillus spp. (6 cases) Mucorales cases). sphenoid ethmoid sinuses commonly affected (10 Orbital invasion cavernous sinus involvement observed 9 4 cases, respectively. Three underwent orbital exenteration survived. Two patients, distinct underlying etiologies pathogens, treated concomitantly hyperbaric oxygen therapy, no reported fatalities. overall mortality rate 58.3%, 41.7% directly attributed Conclusions AIFRS associated high mortality, particularly Establishing standardized surgical criteria essential for improving involving orbit. Additionally, therapy selected different or may contribute improved survival.

Language: Английский

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