Characterization of the Metabolites of Neonicotinoid Insecticide Imidaclothiz in Mice DOI

Ziyue Zhuang,

Yuankai Wang, Muying Du

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(32), P. 17903 - 17911

Published: Aug. 3, 2024

As a member of the neonicotinoid group, imidaclothiz has garnered increasing attention due to its possible health risks. This study investigated metabolism and distribution in mice. Seven metabolites were found, four which are known, three unknown. The metabolic reactions observed hydroxylation, nitrate ester hydrolysis, methylation, urea formation, reduction NO. Precise quantification revealed that after 2 h oral administration, rapidly dispersed into various organs tissues, peaking at 4 h, was then swiftly eliminated. No propensity for accumulation body, particularly liver, observed. Toxicity data from T.E.S.T prediction indicated had moderate toxicity rats, majority more toxic than parent compound. These findings complement existing knowledge environmental fate mammals offer reference point application agriculture industry.

Language: Английский

Impacts of neonicotinoid compounds on the structure and function of Apis mellifera OBP14: Insights from SPR, ITC, multispectroscopy, and molecular modeling DOI

Xiangshuai Li,

Shiyu Li,

Fangkui Zhao

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 250, P. 114551 - 114551

Published: Feb. 3, 2025

Language: Английский

Citations

0
Crosstalk between Tlr4/Nf-Κb, Nrf2-Keap1, and Jak-Stat Signaling Pathways: Possible Mechanism for Ace-Induced Immunotoxicity In Zebrafish Larvae DOI
Guanghua Mao, Dan Li,

Yacan Gong

et al.

Published: Jan. 1, 2024

Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI

Language: Английский

Citations

0
Characterization of the Metabolites of Neonicotinoid Insecticide Imidaclothiz in Mice DOI

Ziyue Zhuang,

Yuankai Wang, Muying Du

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(32), P. 17903 - 17911

Published: Aug. 3, 2024

As a member of the neonicotinoid group, imidaclothiz has garnered increasing attention due to its possible health risks. This study investigated metabolism and distribution in mice. Seven metabolites were found, four which are known, three unknown. The metabolic reactions observed hydroxylation, nitrate ester hydrolysis, methylation, urea formation, reduction NO. Precise quantification revealed that after 2 h oral administration, rapidly dispersed into various organs tissues, peaking at 4 h, was then swiftly eliminated. No propensity for accumulation body, particularly liver, observed. Toxicity data from T.E.S.T prediction indicated had moderate toxicity rats, majority more toxic than parent compound. These findings complement existing knowledge environmental fate mammals offer reference point application agriculture industry.

Language: Английский

Citations

0