Correlation of perfluoroalkyl and polyfluoroalkyl substance levels during pregnancy with gestational diabetes mellitus: a systematic review and meta-analysis

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Background: Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are a major class of contaminants in recent years. Pregnant women more susceptible to the influence these compounds, which could heighten risk developing gestational diabetes mellitus (GDM). This study aims conduct an updated systematic review meta-analysis determine correlation between PFAS exposure during pregnancy GDM delve into their dose-response relationship. Methods: Pubmed, EMBASE, Web Science, Cochrane Library databases were searched. Data statistically analyzed using Stata 15.0. Fixed-effects (FEM) or random-effects (REM) models used combine STD mean difference (SMD) odds ratio (OR) 95% confidence intervals (CIs) according heterogeneity. Dose-response meta-analyses performed when applicable. Results: A total 12 papers included this study. Meta-analysis results indicated significantly higher levels PFOA, PFBS, PFUnDA patients compared healthy pregnant women. exposed high PFOA PFBS had increased GDM, with ORs 1.513 1.436, respectively. analyses that for each 1 ng/ml increase exposure, by 0.3% 11.7%, In contrast, no significant associations observed other such as PFNA, PFHxS, PFOS, development GDM. Subgroup suggested PFOS from China those Western countries. The differences normal pronounced late pregnancy. Conclusion: Exposure is associated Given elevated risk, particularly Chinese population, it crucial reduce substances, especially preconception period onward.

Language: Английский

Correlation of perfluoroalkyl and polyfluoroalkyl substance levels during pregnancy with gestational diabetes mellitus: a systematic review and meta-analysis

BMC Pregnancy and Childbirth, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 14, 2025

Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are a major class of contaminants in recent years. Pregnant women more susceptible to the influence these compounds, which could heighten risk developing gestational diabetes mellitus (GDM). This study aims conduct an updated systematic review meta-analysis determine correlation between PFAS exposure during pregnancy GDM delve into their dose-response relationship. Pubmed, EMBASE, Web Science, Cochrane Library databases were searched. Data statistically analyzed using Stata 15.0. Fixed-effects (FEM) or random-effects (REM) models used combine STD mean difference (SMD) odds ratio (OR) 95% confidence intervals (CIs) according heterogeneity. Dose-response meta-analyses performed when applicable. A total 12 papers included this study. Meta-analysis results indicated significantly higher levels PFOA, PFBS, PFUnDA patients compared healthy pregnant women. exposed high PFOA PFBS had increased GDM, with ORs 1.513 1.436, respectively. analyses that for each 1 ng/ml increase exposure, by 0.3% 11.7%, In contrast, no significant associations observed other such as PFNA, PFHxS, PFOS, development GDM. Subgroup suggested PFOS from China those Western countries. The differences normal pronounced late pregnancy. Exposure is associated Given elevated risk, particularly Chinese population, it crucial reduce substances, especially preconception period onward.

Language: Английский

The impact of vitamin D supplementation on glycemic control and lipid metabolism in polycystic ovary syndrome: a systematic review of randomized controlled trials

BMC Endocrine Disorders, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 21, 2025

Polycystic ovary syndrome (PCOS) is a prevalent endocrine condition affecting both metabolic and reproductive health in women. The impact of vitamin D on regulation has attracted growing interest. purpose this study to investigate the supplementation key parameters-namely blood glucose, insulin, lipid levels-in individuals with PCOS. A systematic review was conducted identify relevant studies PubMed, Embase, Cochrane Library, Web Science, ClinicalTrials.gov. search focused randomized controlled trials (RCTs) evaluating patients Meta-analysis performed using RevMan 5.3 software, quality evaluated Risk Bias Tool. In addition, outcome-related evidence graded GRADE system, TSA determine if number participants met required threshold. total 691 PCOS from 13 RCTs were evaluated. meta-analysis indicated that led notable reduction subsequent parameters: fasting glucose[MD=-2.91 mg/dL, 95% CI (-4.78, -1.04) P = 0.002], insulin levels[MD=-1.98 µIU/mL, (-3.32, -0.64) 0.004], triglycerides[MD=-11.01 (-16.42, -5.61) < 0.0001], cholesterol [MD=-11.69 (-15.56, -7.82) 0.00001], very low-density lipoprotein (VLDL-cholesterol) [MD=-2.64 (-4.50, -0.79) 0.005], (LDL-cholesterol) [MD=-5.85 (-10.28, -1.42) 0.010]. Nevertheless, did not exert significant high - density (HDL cholesterol) [MD=-0.21 (-0.81, 1.22) 0.69]. Begg's Egger's tests suggested minimal probability publication bias, confirmed optimal sample size for major outcomes had been reached, supporting robustness results. Vitamin shows benefits improving parameters patients, particularly reducing levels, suggesting potential role management. long-term most effective dose warrant further investigation future research. Not applicable.

Language: Английский