Branched-chain and Aromatic Amino Acids in Blood and Seminal Plasma are Associated with Sperm Parameters; A Practice within a Fertility Clinic Considering the Metabolic Syndrome
Reproductive Sciences,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 30, 2025
Language: Английский
Enhancing male fertility diagnostics with seminal plasma Raman spectroscopy
Elena Rimskaya,
No information about this author
Alexey Gorevoy,
No information about this author
Aleksandra Yakimova
No information about this author
et al.
Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy,
Journal Year:
2025,
Volume and Issue:
340, P. 126237 - 126237
Published: April 28, 2025
Language: Английский
Supplementation with specific branched-chain amino acids (BCAAs) affects mouse sperm parameters and testicular apoptotic gene expression
Zygote,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 9
Published: May 13, 2025
Summary
In
Western
diets,
high
consumption
of
meat
and
dairy
products,
known
to
be
rich
in
branched-chain
amino
acids
(BCAAs),
including
leucine
(Leu),
isoleucine
(Ile),
valine
(Val),
as
well
BCAAs
supplementation
itself,
may
have
unforeseen
consequences
on
sperm
quality.
addition,
bodybuilders
are
increasingly
resorting
BCAA
build-up
their
muscle
mass.
This
study
aimed
assess
the
effect
dietary
BCAAs,
provided
alone
or
combination,
semen
parameters,
apoptotic
gene
expression,
blood
acid
(AA)
profiles.
To
address
this
question
determine
whether
these
different
a
distinct
impact
quality
testicular
homeostasis,
fifty
NMRI
mature
male
mice
were
exposed
not
supplementations
(control
diet:
CTR;
CTR
+
Leu
supplementation;
Ile
Val
all
three
supplementation).
Only
resulted
significant
decrease
concentration
viability.
only
was
associated
with
dramatic
increase
immotility.
The
Bax/Bcl2
ratio,
an
indicator
apoptosis,
found
significantly
higher
testes
BCAA-supplemented
animals
when
compared
other
groups.
Caspase3
expression
also
Val-supplemented
animals.
There
no
differences
plasma
AA
profiles
between
Thus,
amongst
appears
carry
greatest
functional
parameters
status.
Language: Английский
Associations between Sperm Epigenetic Age and Semen Parameters: An Evaluation of Clinical and Non-Clinical Cohorts
Current Issues in Molecular Biology,
Journal Year:
2024,
Volume and Issue:
46(2), P. 1567 - 1578
Published: Feb. 16, 2024
The
well-documented
relationship
between
chronological
age
and
the
sperm
methylome
has
allowed
for
construction
of
epigenetic
clocks
that
estimate
biological
based
on
DNA
methylation,
which
we
previously
termed
(SEA).
Our
lab
demonstrated
SEA
is
positively
associated
with
time
taken
to
achieve
pregnancy;
however,
its
semen
parameters
unknown.
A
total
379
men
from
Longitudinal
Investigation
Fertility
Environment
(LIFE)
study,
a
non-clinical
cohort,
192
seeking
fertility
treatment
Sperm
Environmental
Epigenetics
Development
Study
(SEEDS)
were
included
in
study.
Semen
analyses
conducted
both
cohorts,
was
generated
using
machine
learning
algorithm
methylation
array
data.
Association
via
multivariable
linear
regression
models
adjusting
BMI
smoking
status.
We
found
not
standard
characteristics
SEEDS
LIFE
cohorts.
However,
significantly
higher
head
length
perimeter,
presence
pyriform
tapered
sperm,
lower
elongation
factor
study
(p
<
0.05).
Based
our
results,
mostly
defects
morphological
factors
are
less
commonly
evaluated
during
male
infertility
assessments.
shows
promise
be
an
independent
biomarker
quality
assess
fecundity.
Language: Английский