Frontiers in Oncology,
Journal Year:
2020,
Volume and Issue:
10
Published: Nov. 27, 2020
Objective:
The
roles
of
long
non-coding
RNAs
(lncRNAs)
in
the
diagnosis
clear
cell
renal
carcinoma
(ccRCC)
are
still
not
well-defined.
We
aimed
to
identify
differentially
expressed
lncRNAs
and
mRNAs
plasma
ccRCC
patients
health
controls
systematically.
Methods:
Expression
profile
healthy
was
analyzed
based
on
microarray
assay.
Gene
ontology
(GO)
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
pathway-based
approaches
were
used
investigate
biological
function
signaling
pathways
mediated
by
mRNAs.
SOCS2-AS1
selected
for
validation
using
Real-Time
PCR.
further
compared
with
E-MTAB-1830
datasets
Venn
NetworkAnalyst
website.
GEPIA
ULCAN
websites
utilized
evaluation
expression
level
mRNA
their
association
overall
survival
(OS).
Results:
A
total
3,664
identified
patients,
including
1,511
up-regulated
2,153
down-regulated
(fold
change
≥2
P
<
0.05),
respectively.
There
2,268
mRNAs,
932
1,336
respectively
0.05).
Pathway
analysis
deregulated
mainly
involved
melanogenesis
Hippo
pathway
(
In
line
lncRNA
findings,
tissues,
as
well
lines.
Compared
gene
profiles,
we
18
87
differently
both
neoplastic
tissues
ccRCC.
10
EPB41L4B,
CCND1,
GGT1,
CGNL1,
CYSLTR1,
PLAUR,
UGT3A1,
PROM2,
MUC12
,
PCK1
)
correlated
(OS)
rate
websites.
Conclusions:
firstly
reported
systemically.
Several
identified,
which
might
serve
diagnostic
or
prognostic
markers.
these
should
be
validated.
Our
study
may
contribute
future
treatment
provide
novel
insights
into
cancer
biology.
International Journal of Biological Sciences,
Journal Year:
2022,
Volume and Issue:
18(6), P. 2583 - 2596
Published: Jan. 1, 2022
Background:The
current
studies
only
indicated
that
long
non-coding
RNA
(lncRNA)
APCDD1L-AS1,
as
a
novel
lncRNA,
may
play
role
in
oral
squamous
cell
carcinoma
and
lung
cancer.However,
its
potential
clear
renal
(ccRCC)
possible
mechanism
of
action
remain
vague.Methods:
TCGA-KIRC
GEO
data
qRT-PCR
pyrosequencing
results
clinical
specimens
were
used
to
identify
the
expression
level
DNA
methylation
status
APCDD1L-AS1.The
effects
APCDD1L-AS1
overexpression
on
ccRCC
growth
metastasis
determined
by
function
experiments.Western
blot
Tandem
mass
tags
(TMT)
utilized
explore
relationship
between
VHL
downstream
underlying
mechanisms.Results:
The
was
downregulated
ccRCC.Decreased
related
higher
tumor
stage
histological
grade
shorter
RFS
(Relapse-free
survival).Besides,
restrained
cells
vitro
vivo.Moreover,
reduced
could
be
caused
hypermethylation
loss
von
Hippel
Lindau
(VHL)
protein
expression.Furthermore,
dysregulation
histones
one
important
mechanisms
suppress
progression
ccRCC.Conclusion:
able
inhibit
ccRCC,
decreased
expression.Therefore,
serve
new
therapeutic
target
treatment
ccRCC.
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
164, P. 115001 - 115001
Published: June 12, 2023
Renal
cell
carcinoma
(RCC)
represents
a
malignant
tumor
of
the
urinary
system.
Individuals
with
early-stage
RCC
could
be
cured
by
surgical
treatment,
but
considerable
number
cases
advanced
progress
to
drug
resistance.
Recently,
numerous
reports
have
demonstrated
that
variety
non-coding
RNAs
(ncRNAs)
contribute
occurrence
and
development.
ncRNAs
can
act
as
oncogenic
or
suppressor
genes
regulate
proliferation,
migration,
resistance
other
processes
in
cells
through
signaling
pathways.
Considering
lack
treatment
options
for
after
resistance,
may
good
choice
biomarkers
targets
overcome
In
this
review,
we
discussed
effects
on
great
potential
biomarker
new
therapeutic
method
RCC.
The FASEB Journal,
Journal Year:
2020,
Volume and Issue:
35(2)
Published: Nov. 4, 2020
Recent
studies
have
showed
that
Small
nucleolar
RNA
host
genes
(SNHGs)
acted
as
a
subset
of
long
noncoding
RNAs
(lncRNAs)
critical
roles
in
human
cancer
carcinogenesis.
However,
the
biological
functions
SNHGs
clear
cell
renal
carcinoma
(ccRCC)
not
been
fully
investigated.
In
this
study,
we
screened
an
oncogenic
lncRNA
termed
SNHG6
using
RNA-Seq
data
ccRCC
from
The
Cancer
Genome
Atlas
(TCGA).
Quantitative
real-time
PCR
was
then
used
to
demonstrate
expression
tissues.
overexpression
is
highly
associated
with
malignant
features
patients
and
prognostic
indicator.
significantly
promotes
proliferation
metastasis
vitro
vivo.
Mechanistic
investigations
identified
exerts
effects
by
interacting
YBX1,
then,
enhancing
HIF1α
translation.
Taken
together,
progression
binding
YBX1
may
serve
novel
molecular
target
for
therapy.
Cancers,
Journal Year:
2021,
Volume and Issue:
13(15), P. 3688 - 3688
Published: July 22, 2021
Breast
cancer
is
the
most
commonly
diagnosed
and
leading
cause
of
mortality
among
women.
Two
thirds
patients
are
classified
as
hormone
receptor
positive,
based
on
expression
estrogen
alpha
(ERα),
main
driver
breast
cell
proliferation,
and/or
progesterone
receptor,
which
regulated
by
ERα.
Despite
presenting
best
prognosis,
these
tumors
can
recur
when
acquire
resistance
to
treatment
aromatase
inhibitors
or
antiestrogen
such
tamoxifen
(Tam).
The
mechanisms
that
involved
in
Tam
complex
involve
multiple
signaling
pathways.
Recently,
roles
for
microRNAs
lncRNAs
controlling
ER
action
have
been
described,
but
underlying
still
little
explored.
In
this
review,
we
will
discuss
current
state
knowledge
positive
cancer.
future,
be
used
identify
at
a
greater
risk
relapse
due
patterns
ncRNAs
impact
response
Tam,
order
guide
their
more
efficiently
possibly
design
therapeutic
strategies
bypass
resistance.
Frontiers in Oncology,
Journal Year:
2020,
Volume and Issue:
10
Published: Nov. 27, 2020
Objective:
The
roles
of
long
non-coding
RNAs
(lncRNAs)
in
the
diagnosis
clear
cell
renal
carcinoma
(ccRCC)
are
still
not
well-defined.
We
aimed
to
identify
differentially
expressed
lncRNAs
and
mRNAs
plasma
ccRCC
patients
health
controls
systematically.
Methods:
Expression
profile
healthy
was
analyzed
based
on
microarray
assay.
Gene
ontology
(GO)
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
pathway-based
approaches
were
used
investigate
biological
function
signaling
pathways
mediated
by
mRNAs.
SOCS2-AS1
selected
for
validation
using
Real-Time
PCR.
further
compared
with
E-MTAB-1830
datasets
Venn
NetworkAnalyst
website.
GEPIA
ULCAN
websites
utilized
evaluation
expression
level
mRNA
their
association
overall
survival
(OS).
Results:
A
total
3,664
identified
patients,
including
1,511
up-regulated
2,153
down-regulated
(fold
change
≥2
P
<
0.05),
respectively.
There
2,268
mRNAs,
932
1,336
respectively
0.05).
Pathway
analysis
deregulated
mainly
involved
melanogenesis
Hippo
pathway
(
In
line
lncRNA
findings,
tissues,
as
well
lines.
Compared
gene
profiles,
we
18
87
differently
both
neoplastic
tissues
ccRCC.
10
EPB41L4B,
CCND1,
GGT1,
CGNL1,
CYSLTR1,
PLAUR,
UGT3A1,
PROM2,
MUC12
,
PCK1
)
correlated
(OS)
rate
websites.
Conclusions:
firstly
reported
systemically.
Several
identified,
which
might
serve
diagnostic
or
prognostic
markers.
these
should
be
validated.
Our
study
may
contribute
future
treatment
provide
novel
insights
into
cancer
biology.