The m6A demethylase FTO promotes renal epithelial-mesenchymal transition by reducing the m6A modification of lncRNA GAS5

Cytokine, Journal Year: 2022, Volume and Issue: 159, P. 156000 - 156000

Published: Sept. 1, 2022

Language: Английский

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SIRT1–SIRT7 in Diabetic Kidney Disease: Biological Functions and Molecular Mechanisms

Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13

Published: May 13, 2022

Diabetic kidney disease (DKD) is a severe microvascular complication in patients with diabetes and one of the main causes renal failure. The current clinical treatment methods for DKD are not completely effective, further exploration molecular mechanisms underlying pathology necessary to improve promote strategy. Sirtuins class III histone deacetylases, which play an important role many biological functions, including DNA repair, apoptosis, cell cycle, oxidative stress, mitochondrial function, energy metabolism, lifespan, aging. In last decade, research on sirtuins has gained increasing attention, it summarize relationship between increase awareness cure rates. We have found that miRNAs, lncRNAs, compounds, or drugs up-regulate activity expression protective roles function. Therefore, this review, we targets, mechanisms, signaling pathways SIRT1-SIRT7 models. Existing shown potential as effective targets DKD. This review aims lay solid foundation provide theoretical basis slow development patients.

Language: Английский

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An overview of natural products that modulate the expression of non-coding RNAs involved in oxidative stress and inflammation-associated disorders

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: April 24, 2023

Oxidative stress is a state in which oxidants are produced excess the body’s tissues and cells, resulting biological imbalance amid generation of reactive oxygen nitrogen species (RONS) from redox reactions. In case insufficient antioxidants to balance, immune system triggers signaling cascades mount inflammatory responses. can have deleterious effects on major macromolecules such as lipids, proteins, nucleic acids, hence, inflammation among multiple factors contributing etiology several disorders diabetes, cancers, cardiovascular diseases. Non-coding RNAs (ncRNAs) were once referred dark matter been found function key regulators gene expression through different mechanisms. They dynamic roles onset development oxidative stress-related diseases, therefore, potential targets for control those One way controlling diseases use natural products, rich source that drawn attention with studies showing their involvement combating chronic given enormous gains, low side effects, toxicity. this review, we highlighted products reported target ncRNAs mediators inflammation-associated disorders. Those include Baicalein, Tanshinone IIA, Geniposide, Carvacrol/Thymol, Triptolide, Oleacein, Curcumin, Resveratrol, Solarmargine, Allicin, aqueous extract or pulp Açai, Quercetin, Genistein. We also draw some other compounds including Zanthoxylum bungeanum , Canna genus rhizome, Fuzi-ganjiang herb pair, Aronia melanocarpa Peppermint, Gingerol effective against inflammation-related disorders, however, no known effect ncRNAs. Lastly, touched many play role but not yet investigated product. Shedding more light into these two last points shadow will be great interest valorization therapy stress-

Language: Английский

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LncRNA GAS5 Suppresses the Proliferation and Invasion of Osteosarcoma Cells via the miR-23a-3p/PTEN/PI3K/AKT Pathway

Cell Transplantation, Journal Year: 2020, Volume and Issue: 29, P. 096368972095309 - 096368972095309

Published: Jan. 1, 2020

Accumulating evidence has shown that long noncoding RNA GAS5 is a well-known tumor suppressor in the pathogenesis of variety human cancers. However, detailed role osteosarcoma still largely unclear. In this study, we found was downregulated tissues and cell lines compared with matched adjacent normal osteoblast cells. Overexpression could significantly suppress growth invasion cells, while downregulation promoted proliferation invasion. We confirmed directly bind miR-23a-3p by using luciferase reporter gene immunoprecipitation pull-down assay. Downregulation repressed counterbalanced inhibition effect on Further studies indicated overexpression inhibited metastasis regulating phosphatase tensin homolog (PTEN). PTEN authenticated as target miR-23a-3p. Upregulation or silence increased level PTEN, suppressed expression PTEN. addition, neutralize downregulating functions. proved regulated viability cells through PI3K/AKT pathway. Moreover, inhibit xenograft nude mouse model vivo. summary, functions competing endogenous RNA, sponging miR-23a-3p, to promote

Language: Английский

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Exosomal hsa_circ_0125310 promotes cell proliferation and fibrosis in diabetic nephropathy via sponging miR‐422a and targeting the IGF1R/p38 axis

Journal of Cellular and Molecular Medicine, Journal Year: 2021, Volume and Issue: 26(1), P. 151 - 162

Published: Dec. 2, 2021

Abstract Diabetic nephropathy (DN) is still on the rise worldwide, and millions of patients have to be treated through dialysis or transplant because kidney failure caused by DN. Recent reports highlighted circRNAs in treatment Herein, we aimed investigate mechanism which high glucose‐induced exo‐circ_0125310 promotes diabetic progression. circ_0125310 highly expressed exosomes isolated from mesangial cells (MCs). High promote proliferation fibrosis MCs. However, results showed that effects MCs can reversed knockdown circ_0125310. miR‐422a, targets IGF1R, was direct target regulated IGF1R/p38 axis sponging miR‐422a. Exo‐circ_0125310 increased luciferase activity WT‐IGF1R reporter dual‐luciferase gene assays upregulated expression level IGF1R p38. Finally, vivo research indicated overexpression promoted Above demonstrated cell via miR‐422a targeting axis.

Language: Английский

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