Immunotherapy in glioblastoma treatment: Current state and future prospects

World Journal of Clinical Oncology, Journal Year: 2023, Volume and Issue: 14(4), P. 138 - 159

Published: April 20, 2023

Glioblastoma remains as the most common and aggressive malignant brain tumor, standing with a poor prognosis treatment prospective. Despite standard care, such surgical resection chemoradiation, median survival rates are low. In this regard, immunotherapeutic strategies aim to become more attractive for glioblastoma, considering its recent advances approaches. review, we provide an overview of current status progress in immunotherapy going through fundamental knowledge on immune targeting promising strategies, Chimeric antigen receptor T-Cell therapy, checkpoint inhibitors, cytokine-based treatment, oncolytic virus vaccine-based techniques. At last, it is discussed innovative methods overcome diverse challenges, future perspectives area.

Language: Английский

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The immunosuppressive microenvironment and immunotherapy in human glioblastoma

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Nov. 17, 2022

Glioblastoma multiforme (GBM) is the most malignant intracranial tumor in adults, characterized by extensive infiltrative growth, high vascularization, and resistance to multiple therapeutic approaches. Among many factors affecting effect, immunosuppressive GBM microenvironment that created cells associated molecules via complex mechanisms plays a particularly important role facilitating evasion of from immune response. Accumulating evidence also revealing close association gut microbiota with challenges treatment GBM. The establishes connection central nervous system through bidirectional signals gut–brain axis, thus occurrence development In this review, we discuss key components microenvironment, along regulatory mechanism involved immunity metabolism microenvironment. Lastly, concentrate on immunotherapeutic strategies currently under investigation, which hold promise overcome hurdles improve outcome for patients

Language: Английский

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Metabolism in the progression and metastasis of brain tumors

Cancer Letters, Journal Year: 2022, Volume and Issue: 539, P. 215713 - 215713

Published: May 3, 2022

Language: Английский

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The Role of Hypoxia and Cancer Stem Cells in Development of Glioblastoma

Cancers, Journal Year: 2023, Volume and Issue: 15(9), P. 2613 - 2613

Published: May 4, 2023

Glioblastoma multiform (GBM) is recognized as the most malignant brain tumor with a high level of hypoxia, containing small population glioblastoma stem like cells (GSCs). These GSCs have capacity self-renewal, proliferation, invasion and recapitulating parent tumor, are major causes radio-and chemoresistance GBM. Upregulated expression hypoxia inducible factors (HIFs) in fundamentally contributes to maintenance progression GSCs. Therefore, we thoroughly reviewed currently acknowledged roles hypoxia-associated development In detail, recapitulated general features GBM, especially GSC-related features, delineated essential responses resulted from interactions between GSC including hypoxia-induced signatures, genes pathways, hypoxia-regulated metabolic alterations. Five hypothesized niches discussed integrated into one comprehensive concept: hypoxic peri-arteriolar niche Autophagy, another protective mechanism against chemotherapy, also closely related potential therapeutic target for addition, resistance (chemo-, radio-, surgical-, immuno-), chemotherapeutic agents which can improve effects chemo-, or immunotherapy introduced discussed. At last, approach reverse microenvironment hyperbaric oxygen therapy (HBOT) might be an adjuvant chemo-and radiotherapy after surgery. conclusion, focus on demonstrating important role by affecting function Important advantages been made understand complicated induced Further exploration targeting help develop novel strategies survival GBM patients.

Language: Английский

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KMT2D mutations promoted tumor progression in diffuse large B-cell lymphoma through altering tumor-induced regulatory T cell trafficking via FBXW7-NOTCH-MYC/TGF-β1 axis

International Journal of Biological Sciences, Journal Year: 2024, Volume and Issue: 20(10), P. 3972 - 3985

Published: Jan. 1, 2024

Histone methyltransferase

Language: Английский

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The Basis and Advances in Clinical Application of Cytomegalovirus-Specific Cytotoxic T Cell Immunotherapy for Glioblastoma Multiforme

Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 12

Published: April 19, 2022

A high percentage of malignant gliomas are infected by human cytomegalovirus (HCMV), and the endogenous expression HCMV genes their products found in these tumors. antigen its implications gliomagenesis have emerged as a promising target for adoptive cellular immunotherapy (ACT) strategies glioblastoma multiforme (GB) patients. Since antigen-specific T cells tumor microenvironments lack efficient anti-tumor immune response due to immunosuppressive nature glioblastoma, CMV-specific ACT relies on

Language: Английский

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Comprehensive Analysis of Sterol O-Acyltransferase 1 as a Prognostic Biomarker and Its Association With Immune Infiltration in Glioma

Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 12

Published: May 12, 2022

Metabolic reprogramming is a hallmark of glioma, and sterol O-acyltransferase 1 (SOAT1) an essential target for metabolic therapy. However, the prognostic value SOAT1 its association with immune infiltration has not been fully elucidated. Using RNA-seq clinical data glioma patients from The Cancer Genome Atlas (TCGA), was found to be correlated poor prognosis in advanced malignancy clinicopathological characteristics. Next, correlation between expression tumor-infiltrating cells performed using single-sample GSEA algorithm, gene profiling interactive analysis (GEPIA), tumor estimation resource version 2 (TIMER2.0); it that positively multiple cells. To further verify these results, immunofluorescence conducted on paraffin-embedded specimens, positive trend Treg observed this cohort. Finally, differentially expressed analysis, Gene Ontology Kyoto Encyclopedia Genes Genomes analyses were explore biological processes signaling pathways may involved during pathogenesis. A protein-protein interaction network established, co-expression investigate regulatory mechanism glioma. best our knowledge, first comprehensive study reporting serve as novel biomarker associated infiltrates, providing perspective

Language: Английский

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Hijacking Sexual Immuno-Privilege in GBM—An Immuno-Evasion Strategy

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(20), P. 10983 - 10983

Published: Oct. 12, 2021

Regulatory T-cells (Tregs) are immunosuppressive T-cells, which arrest immune responses to ‘Self’ tissues. Some Tregs that recognize seminal epitopes suppress the proteins in semen, both men and women. We postulated GBMs express reproductive-associated manipulate reproductive gain privilege. analyzed four GBM transcriptome databases representing ≈900 tumors for hypoxia-responsive Tregs, steroidogenic pathways, sperm/testicular placenta-specific genes, stratifying by expression. In silico analysis suggested presence of was associated with worse patient outcomes. These have an androgenic signature, male-specific antigens, attract Related Orphan Receptor C (RORC)-Treg cells. sera were interrogated anti-sperm/testicular antibodies, along age-matched controls, utilizing monkey testicle sections. serum contained antibodies at levels > six-fold controls. Myeloid-derived suppressor cells (MDSCs) tumor-associated macrophages (TAMs) estrogenic appear mimic placental tissue. demonstrate RORC-Tregs drive poor outcome, Treg infiltration correlates strongly androgen levels. Androgens support expression allowing from patient’s system infiltrate tumor. contrast, estrogen appears responsible MDSC/TAM immunosuppression.

Language: Английский

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An Immune-Related Gene Pairs Signature for Predicting Survival in Glioblastoma

Frontiers in Oncology, Journal Year: 2021, Volume and Issue: 11

Published: March 30, 2021

Background: Glioblastoma (GBM) is the frequently occurring and most aggressive form of brain tumors. In study, we constructed an immune-related gene pairs (IRGPs) signature to predict overall survival (OS) in patients with GBM. Methods: We established IRGPs (IRG) matrix from The Cancer Genome Atlas (TCGA) database (Training cohort). After screened by univariate regression analysis least absolute shrinkage selection operator (LASSO) analysis, were subjected multivariable Cox develop IRGP signature. Then, predicting accuracy was assessed area under receiver operating characteristic curve (AUC) validated result using Chinese Glioma (CGGA) (Validation cohorts 1 2). Results: A 10-IRGP for OS AUC 1-, 3-, 5-year Training cohort 0.801, 0.901, 0.964, respectively, line Validation 2 [Validation (1 year: 0.763; 3 years: 0.786; 5 0.884); 0.745; 0.989; 0.987)]. Moreover, three suggested that low-risk GBM had better clinical outcomes than high-risk demonstrated independent prognostic factor. Conclusions: developed a novel

Language: Английский

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Nomograms for prognostic risk assessment in glioblastoma multiforme: Applications and limitations

Clinical Genetics, Journal Year: 2022, Volume and Issue: 102(5), P. 359 - 368

Published: July 27, 2022

Glioblastoma multiforme (GBM) is the most common and aggressive form of brain cancer. Prognosis evaluation great significance in guiding individualized treatment monitoring GBM. By integrating different prognostic variables, nomograms simplify statistical risk prediction model into numerical estimates for death or recurrence, are hence widely applied prognosis prediction. In past two decades, application high-throughput profiling technology establishment TCGA database other public data deposits have provided opportunities to identify cancer-related molecules biomarkers. As a result, both molecular features clinical characteristics cancer been reported be key factors nomogram construction. This article comprehensively reviewed 35 studies GBM nomograms, analyzed present situation discussed role personalized assessment decision-making. To facilitate patients, website has established online access based on this review, which called Consensus Nomogram Spectrum (CNSgbm) accessible through https://bioinfo.henu.edu.cn/nom/NomList.jsp.

Language: Английский

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