Structural racism in primary schools and changes in epigenetic age acceleration among Black and White youth

Social Science & Medicine, Journal Year: 2024, Volume and Issue: 347, P. 116724 - 116724

Published: March 2, 2024

Language: Английский

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Stability of Aging‐ and Cognition‐Related Methylation Profile Scores Across Two Waves in Children and Adolescents

Child Development, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

DNA-methylation profile scores (MPSs) index biology relevant for lifelong physical and cognitive health, but information on their longitudinal stability in childhood is lacking. Using two waves of data collected from 2014 to 2022 (Mlag between = 2.41 years) N 407 participants (Mage 12.05 years, 51% female, 60% White), test-retest correlations were estimated four salivary MPSs related aging (PhenoAgeAccel, GrimAgeAccel, DunedinPACE), function (Epigenetic-g). varied (test-retest rs 0.38 0.76). did not differ children exposed the COVID-19 pandemic, race-ethnic sex differences apparent. Further research necessary understand which environmental perturbations impact trajectories when are most sensitive those impacts.

Language: Английский

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Cross-National and Cross-Generational Evidence That Educational Attainment May Slow the Pace of Aging in European-Descent Individuals

The Journals of Gerontology Series B, Journal Year: 2023, Volume and Issue: 78(8), P. 1375 - 1385

Published: April 14, 2023

Individuals with more education are at lower risk of developing multiple, different age-related diseases than their less-educated peers. A reason for this might be that individuals age slower. There 2 complications in testing hypothesis. First, there exists no definitive measure biological aging. Second, shared genetic factors contribute toward both educational attainment and the development diseases. Here, we tested whether protective effect was associated pace aging after accounting factors.

Language: Английский

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A blood biomarker of the pace of aging is associated with brain structure: replication across three cohorts

Neurobiology of Aging, Journal Year: 2024, Volume and Issue: 136, P. 23 - 33

Published: Jan. 24, 2024

Language: Английский

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Accelerated Pace of Aging in Schizophrenia: Five Case-Control Studies

Biological Psychiatry, Journal Year: 2023, Volume and Issue: 95(11), P. 1038 - 1047

Published: Nov. 2, 2023

Language: Английский

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Map of epigenetic age acceleration: a worldwide analysis

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 100, P. 102418 - 102418

Published: July 14, 2024

Language: Английский

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Epigenetic age acceleration is related to cognitive decline in the elderly: Results of the Austrian Stroke Prevention Study

Psychiatry and Clinical Neurosciences, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Epigenetic clocks, quantifying biological age through DNA methylation (DNAmAge), have emerged as potential indicators of brain aging. As the variety DNAmAge algorithms grows, consensus on their efficacy in predicting age-related changes is lacking. This study aimed to explore intricate relationship between diverse and structural cognitive markers Within a cohort 796 elderly patients (mean age, 65.8 ± 7.9 years), we scrutinized 11 algorithms, including Horvath, Hannum, Zhang's PhenoAge, GrimAge, DunedinPACE, principal component (PC)-based PCHorvath, PCHannum, PCPhenoAge, PCGrimAge. We evaluated association with baseline cognition decline, assessed follow-up evaluations at three (T1) six (T2) years postbaseline. Additionally, examined magnetic resonance imaging aging, white matter. clock was best predictor decline memory (β = -0.04) global -0.03), whereas PCGrimAge speed -0.17). The were second-best predictors explaining variability after education (R2 partial 1.66% 2.82%) for 2.13%). PC-trained outperformed respective original version. are strong independent normal population explain additional beyond that accounted by conventional risk factors.

Language: Английский

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Translational Geroscience

Oxford University Press eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 271 - 290

Published: Feb. 20, 2025

Abstract Translational Geroscience is rooted in the geroscience paradigm which seeks to define genetic, molecular, and cellular mechanisms that make age major risk factor driver of most chronic conditions diseases older people. The final aim convert this fundamental knowledge into effective interventions promote healthy ageing. In chapter, we discuss how interfaces with life course epidemiology through emerging tools assess biological age. It has potential shift focus medicine from current model disease treatment an emphasis on counteracting ageing phenotypes during one’s full expand health expectancy. We claim advances biomarker technologies, science approaches, mechanism-based therapeutic strategies, a day when individuals will be spending their good within sight.

Language: Английский

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Applying blood-derived epigenetic algorithms to saliva: cross-tissue similarity of DNA-methylation indices of aging, physiology, and cognition

Clinical Epigenetics, Journal Year: 2025, Volume and Issue: 17(1)

Published: April 23, 2025

Abstract Background Epigenetic algorithms of aging, health, and cognition, based on DNA-methylation (DNAm) patterns, are prominent tools for measuring biological age have been linked to age-related diseases, cognitive decline, mortality. While most these methylation profile scores (MPSs) developed in blood tissue, there is growing interest using less invasive tissues like saliva. The aim the current study probe cross-tissue intraclass correlation coefficients (ICCs) MPSs applied saliva DNAm from same people. our primary focus that were previously found be robustly correlated with social determinants including second- third-generation clocks physiology we also report ICC values first-generation enable comparison across metrics. We pooled three publicly available datasets had both individuals (total n = 107, aged 5–74 years), corrected cell composition within each computed ICCs. Results after correcting composition, saliva–blood ICCs moderate indices aging cognition. Specifically, PCGrimAge highest (0.76), followed by PCPhenoAge (0.72), a measure performance (Epigenetic- g , 0.69), DunedinPACE (0.68), Acceleration (0.67), (0.66), an MPS hs-CRP (0.58), BMI (0.54). These appear lower than previous reports within-tissue (saliva range 0.67 0.85, 0.73 0.93). Cross-tissue acceleration measures poor, ranging 0.19 0.25. Conclusions Our findings suggest applying related phenotypes results similarity precise correspondence differs measure. degree several may suffice some research settings, it not suitable clinical or commercial applications. Collection samples necessary validate existing customize DNAm.

Language: Английский

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Associations Between Longitudinal Loneliness, DNA Methylation Age Acceleration, and Cognitive Functioning

The Journals of Gerontology Series B, Journal Year: 2023, Volume and Issue: 78(12), P. 2045 - 2059

Published: Sept. 18, 2023

Abstract Objectives Loneliness may influence aging biomarkers related to cognitive functioning, for example, through accelerated DNA methylation (DNAm) aging. Methods In the present study, we tested whether six common DNAm age acceleration measures mediated effects of baseline loneliness and five different longitudinal trajectories on general ability, immediate memory recall, delayed processing speed in 1,814 older adults Health Retirement Study. Results We found that individuals who belong highest had poorer ability scores. Only index physiological comorbidities, unhealthy lifestyle factors (e.g., smoking), mortality risk-mediated functioning but not speed. These same moderate-but-declining trajectory functioning. Additionally, scores were by GrimAge Accel lowest two groups. Total outcomes mainly accounted demographic, social, psychological, covariates, most notably self-rated health, depressive symptomatology, objective social isolation, body mass index. Discussion Current findings suggest aging, particularly Accel, have promise explaining prospective association between outcomes.

Language: Английский

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