Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: May 9, 2023
Abstract
Background
Despite
the
absence
of
scientific
data
supporting
real
impact
drinking
on
elderly
individuals,
alcohol
abuse
is
a
common
feature
older
people.
Because
aging
associated
with
biological
changes
that
include
reduced
water
volume
in
body,
lower
efficiency
liver
enzymes
and
hepatic
blood
flow,
altered
brain
responsiveness
due
to
drug
interactions,
individuals
are
more
prone
harmful
effects
consumption.
The
adverse
acute
or
chronic
exposure
ethanol
have
been
extensively
recognized
cerebellar
circuits,
impairment
movement
balance.
In
addition
motor
deterioration,
degeneration
contributes
distinct
neuropsychological
deficits
alcoholics
children
prenatal
ethanol.
However,
senile
unclear.
This
study
determines
pattern
MicroRNAs,
gene
expressions,
apoptotic
anti-apoptotic
protein
levels,
ultrastructural
analysis
neurons
contribute
understanding
consequences
cerebellum.
Methods
Results
results
immunohistochemical
expressions
for
Caspase-3,
XIAP,
IGFR-1
were
similar
both
groups.
Serum
levels
miR-9-3p,
-15b-5p,
-16-5p,
-21,
−
200a,
222-3p
upregulated
presence
aging.
Conclusions
suggest
an
important
tolerance
development
by
UChB
rats
consumption
aged
cerebellum,
miRNAs
may
be
potentially
involved
this
mechanism.
Genes,
Journal Year:
2024,
Volume and Issue:
15(12), P. 1599 - 1599
Published: Dec. 14, 2024
Background/Objectives:
Aging
is
a
natural
physiological
process
involving
biological
and
genetic
pathways.
Growing
evidence
suggests
that
alterations
in
the
epigenome
during
aging
result
transcriptional
changes,
which
play
significant
role
onset
of
age-related
diseases,
including
cancer,
cardiovascular
disease,
diabetes,
neurodegenerative
disorders.
For
this
reason,
epigenetic
diseases
have
been
reviewed,
major
extrinsic
factors
influencing
these
identified.
In
addition,
gut
microbiome
its
metabolites
as
modifiers
has
addressed.
Results:
Long-term
exposure
to
such
air
pollution,
diet,
drug
use,
environmental
chemicals,
microbial
infections,
physical
activity,
radiation,
stress
provoke
changes
host
through
several
endocrine
immune
pathways,
potentially
accelerating
process.
Diverse
studies
reported
plays
critical
regulating
brain
cell
functions
DNA
methylation
histone
modifications.
The
interaction
between
genes
serves
source
adaptive
variation,
contributing
phenotypic
plasticity.
However,
molecular
mechanisms
signaling
pathways
driving
are
still
not
fully
understood.
Conclusions:
Extrinsic
potential
inducers
alterations,
may
important
implications
for
longevity.
an
effector
gene
expression
modifications,
while
bidirectional
interactions
with
underexplored
roles
non-bacterial
microorganisms
fungi
viruses
highlight
need
further
research.
Journal of Mood and Anxiety Disorders,
Journal Year:
2023,
Volume and Issue:
3, P. 100026 - 100026
Published: Sept. 21, 2023
Advanced
epigenetic
age
is
associated
with
psychopathology
and
may
help
to
explain
the
link
between
physical
health
morbidity
mortality.
Using
a
longitudinal
sample
of
171
trauma-exposed
Veterans,
we
modeled
rate
change
in
across
two
time
points
(averaging
5.58
years
apart)
using
algorithms
(GrimAge
Horvath)
tested
associations
posttraumatic
stress
disorder
(PTSD),
alcohol
use
(AUD),
depression.
Results
showed
that
PTSD
(β
=
.199)
AUD
.186)
were
quickened
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(9), P. 1985 - 1985
Published: Sept. 2, 2024
DNA
methylation,
validated
as
a
surrogate
for
biological
age,
is
potential
tool
predicting
future
morbidity
and
mortality
outcomes.
This
study
aims
to
explore
how
lifestyle
patterns
are
associated
with
epigenetic
changes
in
British
men.
Five
age
clocks
were
utilised
investigate
the
relationship
between
these
markers
lifestyle-related
factors
prospective
involving
221
participants.
Spearman’s
correlation
test,
Pearson’s
univariate
linear
regression
employed
analysis.
The
results
indicate
that
higher
consumption
of
saturated
fat
total
daily
calories,
body
mass
index
(BMI)
accelerated
aging.
Conversely,
vitamin
D
intake
healthy
(HLI)
linked
decelerated
These
findings
highlight
impact
specific
on
aging
can
serve
reference
applying
improvements
disease
prevention
studies.
Genome Medicine,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: Nov. 8, 2024
Phenotypic
age
(PhenoAge),
a
widely
used
marker
of
biological
aging,
has
been
shown
to
be
robust
predictor
all-cause
mortality
and
morbidity
in
different
populations.
Existing
studies
on
aging
have
primarily
focused
individual
domains,
resulting
lack
comprehensive
understanding
the
multi-systemic
dysregulation
that
occurs
aging.
Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: May 9, 2023
Abstract
Background
Despite
the
absence
of
scientific
data
supporting
real
impact
drinking
on
elderly
individuals,
alcohol
abuse
is
a
common
feature
older
people.
Because
aging
associated
with
biological
changes
that
include
reduced
water
volume
in
body,
lower
efficiency
liver
enzymes
and
hepatic
blood
flow,
altered
brain
responsiveness
due
to
drug
interactions,
individuals
are
more
prone
harmful
effects
consumption.
The
adverse
acute
or
chronic
exposure
ethanol
have
been
extensively
recognized
cerebellar
circuits,
impairment
movement
balance.
In
addition
motor
deterioration,
degeneration
contributes
distinct
neuropsychological
deficits
alcoholics
children
prenatal
ethanol.
However,
senile
unclear.
This
study
determines
pattern
MicroRNAs,
gene
expressions,
apoptotic
anti-apoptotic
protein
levels,
ultrastructural
analysis
neurons
contribute
understanding
consequences
cerebellum.
Methods
Results
results
immunohistochemical
expressions
for
Caspase-3,
XIAP,
IGFR-1
were
similar
both
groups.
Serum
levels
miR-9-3p,
-15b-5p,
-16-5p,
-21,
−
200a,
222-3p
upregulated
presence
aging.
Conclusions
suggest
an
important
tolerance
development
by
UChB
rats
consumption
aged
cerebellum,
miRNAs
may
be
potentially
involved
this
mechanism.
