Swertiamarin and sweroside are potential inhibitors of COVID-19 based on the silico analysis DOI Creative Commons
Wenxiang Wang, Ying Tan, Jingxin Mao

et al.

Medicine, Journal Year: 2024, Volume and Issue: 103(45), P. e40425 - e40425

Published: Nov. 8, 2024

The severity of the respiratory disease caused by severe acute syndrome coronavirus 2 has escalated rapidly in recent years, posing a significant threat to global health. Sweroside and swertiamarin are bioactive iridoid glycosides extracted mainly from Swertia davidii Franch. It remains unclear how Specifically affects COVID-19 its underlying mechanisms. We first employed network pharmacology molecular docking techniques investigate sweroside affect order explore potential mechanism. found that 35 target genes can be used for treatment COVID-19, with androgen receptor (AR), HSP90AA1, RAC-alpha serine/threonine-protein kinase, cyclin-dependent kinase 1, epidermal growth factor receptor, glycogen synthase kinase-3 beta emerging as particularly promising candidates. Additionally, demonstrated unambiguous interactions 3CL protease AR through research. At active site, bind (1T65), main (5R82), (6M2N), showing therapeutic potential.

Language: Английский

Iron and copper: critical executioners of ferroptosis, cuproptosis and other forms of cell death DOI Creative Commons
Yu Li,

Yuhui Du,

Yujie Zhou

et al.

Cell Communication and Signaling, Journal Year: 2023, Volume and Issue: 21(1)

Published: Nov. 16, 2023

Abstract Regulated cell death (RCD) is a regulable that involves well-organized signaling cascades and molecular mechanisms. RCD implicated in fundamental processes such as organ production tissue remodeling, removing superfluous structures or cells, regulating numbers. Previous studies have not been able to reveal the complete mechanisms, novel methods of are constantly being proposed. Two metal ions, iron (Fe) copper (Cu) essential factors leading RCDs only induce ferroptosis cuproptosis, respectively but also lead impairment eventually diverse death. This review summarizes direct indirect mechanisms by which Fe Cu impede growth various forms mediated these two metals. Moreover, we aimed delineate interrelationships between with distinct pathways shedding light on complex intricate govern cellular survival Finally, prospects outlined this suggest approach for investigating death, may involve integrating current therapeutic strategies offer promising solution overcome drug resistance certain diseases.

Language: Английский

Citations

72
Regulation of Ferroptosis in Lung Adenocarcinoma DOI Open Access

Xiangyun Wei,

Xiaohe Li,

Shuming Hu

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(19), P. 14614 - 14614

Published: Sept. 27, 2023

Lung adenocarcinoma (LUAD) is the most common lung cancer, which accounts for about 35-40% of all cancer patients. Despite therapeutic advancements in recent years, overall survival time LUAD patients still remains poor, especially KRAS mutant LUAD. Therefore, it necessary to further explore novel targets and drugs improve prognos Ferroptosis, an iron-dependent regulated cell death (RCD) caused by lipid peroxidation, has attracted much attention recently as alternative target apoptosis therapy. Ferroptosis been found be closely related at every stage, including initiation, proliferation, progression. In this review, we will provide a comprehensive overview ferroptosis mechanisms, its regulation LUAD, application targeting

Language: Английский

Citations

30
Ferroptosis and cuproptosis in periodontitis: recent biological insights and therapeutic advances DOI Creative Commons
Tengyi Zheng, Fangguo Lu, Po‐Ying Wu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 24, 2025

Periodontitis is a significant global public health issue associated with the onset and progression of various systemic diseases, thereby requiring additional research clinical attention. Although ferroptosis cuproptosis have emerged as areas in medical field, their precise roles pathogenesis periodontitis remain unclear. We aim to systematically summarize current on periodontal disease investigate glutathione pathway autophagy connecting during periodontitis. Further, we propose that homeostatic imbalance copper iron, driven by pathogens, may contribute elevated oxidative stress, representing potential unifying link between involved This article presents comprehensive overview molecular mechanisms underlying periodontitis, offering novel theoretical insights into its therapeutic targets.

Language: Английский

Citations

1
Bioinformatics analysis to disclose shared molecular mechanisms between type-2 diabetes and clear-cell renal-cell carcinoma, and therapeutic indications DOI Creative Commons

Reaz Ahmmed,

Md. Bayazid Hossen,

Alvira Ajadee

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Aug. 19, 2024

Type 2 diabetes (T2D) and Clear-cell renal cell carcinoma (ccRCC) are both complicated diseases which incidence rates gradually increasing. Population based studies show that severity of ccRCC might be associated with T2D. However, so far, no researcher yet investigated about the molecular mechanisms their association. This study explored T2D causing shared key genes (sKGs) from multiple transcriptomics profiles to investigate common pathogenetic processes drug molecules. We identified 259 differentially expressed (sDEGs) can separate patients control samples. Local correlation analysis on expressions sDEGs indicated significant association between ccRCC. Then ten (CDC42, SCARB1, GOT2, CXCL8, FN1, IL1B, JUN, TLR2, TLR4, VIM) were selected as sKGs through protein-protein interaction (PPI) network analysis. These found significantly different CpG sites DNA methylation cause The sKGs-set enrichment Gene Ontology (GO) terms KEGG pathways revealed some crucial functions, biological process, cellular components development regulatory six post-transcriptional regulators (hsa-mir-93-5p, hsa-mir-203a-3p, hsa-mir-204-5p, hsa-mir-335-5p, hsa-mir-26b-5p, hsa-mir-1-3p) five transcriptional (YY1, FOXL1, FOXC1, NR2F1 GATA2) sKGs. Finally, sKGs-guided top-ranked three repurposable molecules (Digoxin, Imatinib, Dovitinib) recommended treatment for by docking ADME/T Therefore, results this may useful diagnosis therapies who also suffering

Language: Английский

Citations

5
Harnessing nanomaterials for copper-induced cell death DOI

Su-Ran Li,

Shi-Yue Tao,

Qian Li

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 313, P. 122805 - 122805

Published: Sept. 3, 2024

Language: Английский

Citations

5
Identification of AURKA as a Biomarker Associated with Cuproptosis and Ferroptosis in HNSCC DOI Open Access
Xiao Jia,

Jiao Tian,

Yueyue Fu

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(8), P. 4372 - 4372

Published: April 16, 2024

Cuproptosis and ferroptosis represent copper- iron-dependent forms of cell death, respectively, both are known to play pivotal roles in head neck squamous carcinoma (HNSCC). However, few studies have explored the prognostic signatures related cuproptosis HNSCC. Our objective was construct a model based on genes associated with ferroptosis. We randomly assigned 502 HSNCC samples from The Cancer Genome Atlas (TCGA) into training testing sets. Pearson correlation analysis utilized identify cuproptosis-associated set. Cox proportional hazards (COX) regression least absolute shrinkage operator (LASSO) were employed model. performance internally validated using single-factor COX regression, multifactor Kaplan–Meier analysis, principal component (PCA), receiver operating curve (ROC) analysis. Additionally, we obtained 97 Gene Expression Omnibus (GEO) database for external validation. constructed model, 12 genes, proved be an independent predictor HNSCC prognosis. Among these increased expression aurora kinase A (AURKA) has been implicated various cancers. To further investigate, small interfering RNAs (siRNAs) knock down AURKA conducted functional experiments. results demonstrated that knockdown significantly inhibited proliferation migration cells (Cal27 CNE2). Therefore, may serve as potential biomarker

Language: Английский

Citations

4
Neuronal regulated cell death in aging-related neurodegenerative diseases: key pathways and therapeutic potentials DOI Creative Commons
Run Song, Shiyi Yin, Jiannan Wu

et al.

Neural Regeneration Research, Journal Year: 2024, Volume and Issue: 20(8), P. 2245 - 2263

Published: July 29, 2024

Regulated cell death (such as apoptosis, necroptosis, pyroptosis, autophagy, cuproptosis, ferroptosis, disulfidptosis) involves complex signaling pathways and molecular effectors, has been proven to be an important regulatory mechanism for regulating neuronal aging death. However, excessive activation of regulated may lead the progression aging-related diseases. This review summarizes recent advances in understanding seven forms age-related Notably, newly identified ferroptosis cuproptosis have implicated risk cognitive impairment neurodegenerative These exacerbate disease by promoting inflammation, oxidative stress, pathological protein aggregation. The also provides overview key crosstalk mechanisms among these forms, with a focus on disulfidptosis. For instance, FDX1 directly induces copper ion valency dihydrolipoamide S-acetyltransferase aggregation, while mediates glutathione peroxidase 4 degradation, enhancing sensitivity. Additionally, inhibiting Xc- transport system prevent can increase disulfide formation shift NADP + /NADPH ratio, transitioning insights help uncover potential connections novel differentiate them from traditional mechanisms. In conclusion, identifying targets their points various aid developing specific biomarkers reverse clock treat conditions.

Language: Английский

Citations

4
G-CSF promotes the development of hepatocellular carcinoma by activating the PI3K/AKT/mTOR pathway in TAM DOI Creative Commons
Heng Cao, Shunxiang Wang

Aging, Journal Year: 2024, Volume and Issue: unknown

Published: July 1, 2024

This investigation seeks to elucidate the role of Granulocyte Colony-Stimulating Factor (G-CSF) in progression hepatocellular carcinoma (HCC), as well impact substance on related signaling pathways within disease matrix.

Language: Английский

Citations

3
Exploring the immunological mechanism of Houttuynia cordata in the treatment of colorectal cancer through combined network pharmacology and experimental validation DOI
Yao Li,

Jinxiu Wu,

Sicong Jiang

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: 397(11), P. 9095 - 9110

Published: June 18, 2024

Language: Английский

Citations

2
FKBP3, a poor prognostic indicator, promotes the progression of LUAD via regulating ferroptosis and immune infiltration DOI Creative Commons

Shengyi Li,

Lexin Yang,

Jing Li

et al.

Medicine, Journal Year: 2024, Volume and Issue: 103(26), P. e38606 - e38606

Published: June 28, 2024

Background: Ferroptosis was reported to possess the therapeutic potentials in various human cancers. In present study, we explored expression, clinical significance and molecular mechanism of FK506 binding protein 3 (FKBP3) progression lung adenocarcinoma (LUAD). Material Method: Cox regression performed obtain prognosis related differentially expressed genes (DEGs) LUAD datasets from TCGA. We also downloaded ferroptosis-related gene GeneCards. Venn diagram find intersecting FKBP3 selected as targeted by analyzing diagnostic prognostic values Top10 genes. Moreover, univariate multivariate analyses were evaluate association between clinicopathological factors survival rates. GO/KEGG GSEA analysis explore function progression. Protein-protein interaction (PPI) network via STRING database top10 hub selected. Finally, relationship immune infiltration ssGSEA analysis. Results: Firstly, 184 associated with ferroptosis obtained. found be significantly a poor overall rate patients. Immunohistochemical staining results showed that highly located cytoplasm membrane cells tissues. PPI HDAC1, YY1, HDAC2, MTOR, PSMA3, PIN1, NCL, C14orf166, PIN4, LARP6 Furthermore, spearman expression positively correlated abundance Th2 T helper cells. Conclusion: High level outcomes patients, which inhibited Additionally, involved regulating process Thus, possessed tumor promotion role might involving

Language: Английский

Citations

2