Posttranslational modifications in retinal degeneration diseases: An update on the molecular basis and treatment DOI Creative Commons
Ke Yao,

Qianxue Mou,

Zhen Jiang

et al.

Brain‐X, Journal Year: 2024, Volume and Issue: 2(3)

Published: Sept. 1, 2024

Abstract Noninherited diseases and age‐associated vision loss are often associated with retinal degeneration. The retina is a postmitotic neural tissue lacking endogenous regeneration capacity. Therefore, understanding the mechanism of degeneration in pivotal. Posttranslational modifications (PTMs) determine protein function during physiological pathological processes, including signal transduction, localization, activation. Advanced detection technologies have revealed over 400 different PTMs acetylation, methylation, phosphorylation, ubiquitination SUMOylation. Here, we discuss to aid our their molecular basis suggest potential future clinical treatment.

Language: Английский

The Role of Non-coding RNAs in Diabetic Retinopathy: Mechanistic Insights and Therapeutic Potential DOI

Zhuan Zuo,

Ni Li, Qian Zhang

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Posttranslational modifications in retinal degeneration diseases: An update on the molecular basis and treatment DOI Creative Commons
Ke Yao,

Qianxue Mou,

Zhen Jiang

et al.

Brain‐X, Journal Year: 2024, Volume and Issue: 2(3)

Published: Sept. 1, 2024

Abstract Noninherited diseases and age‐associated vision loss are often associated with retinal degeneration. The retina is a postmitotic neural tissue lacking endogenous regeneration capacity. Therefore, understanding the mechanism of degeneration in pivotal. Posttranslational modifications (PTMs) determine protein function during physiological pathological processes, including signal transduction, localization, activation. Advanced detection technologies have revealed over 400 different PTMs acetylation, methylation, phosphorylation, ubiquitination SUMOylation. Here, we discuss to aid our their molecular basis suggest potential future clinical treatment.

Language: Английский

Citations

0