Association of DNA methylation age acceleration with digital clock drawing test performance: the Framingham Heart Study DOI Creative Commons

Zexu Li,

Huitong Ding, Mengyao Wang

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 7, 2024

Abstract Background Cognitive function measured by digital clock drawing test (dCDT) has drawn attention for their precision, automation, and reproductivity. However, the relationship between cognitive metrics biological aging is lacking. Methods We conducted association analyses dCDT quantified five DNA methylation (DNAm) age (Horvath, Hannum, GrimAge, PhenoAge, DunedinPACE) in Framingham Heart Study (FHS). linear regression to investigate functions (global four sub-domain functions) DNAm acceleration, adjusting covariates. used a false discovery rate (FDR) < 0.05 significance. Results Among 1,798 FHS participants (mean 65±13, 53% women), we found that lower total score associated with acceleration. Larger magnitudes of associations were observed older (≥ 65 years). The showed strongest DundinPACE pooled sample (beta = −2.1, FDR 0.0004), younger −1.9, 0.02), group −2.2, 0.01). was significantly acceleration estimated Horvath (beta=-1.9, =0.01) PhenoAge (beta=-2.5, FDR=0.01) while not or (<65 In functions, simple motor DunedinPACE (FDR 0.005) both groups GrimAge group), indicating deterioration various organ systems may particularly impact this domain. Discussion Our findings suggest middle-aged FHS, potentially shedding light on epigenetic mechanisms underlying digitally function.

Language: Английский

The Association between Dietary Nutrient Intake and Acceleration of Aging: Evidence from NHANES DOI Open Access

MA Jian-hua,

Ping-An Li, Yue Jiang

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(11), P. 1635 - 1635

Published: May 27, 2024

The acceleration of aging is a risk factor for numerous diseases, and diet has been identified as an especially effective anti-aging method. Currently, research on the relationship between dietary nutrient intake accelerated remains limited, with existing studies focusing small number individual nutrients. Comprehensive single mixed effects nutrients not conducted. This study aimed to comprehensively explore intakes, both singly in combination, aging. Data this were extracted from 2015–2018 National Health Nutrition Examination Surveys (NHANES). was measured by phenotypic age acceleration. Linear regression (linear), restricted cubic spline (RCS) (nonlinear), weighted quantile sum (WQS) (mixed effect) models used association A total 4692 participants aged ≥ 20 included study. In fully adjusted models, intakes 16 negatively associated (protein, vitamin E, A, beta-carotene, B1, B2, B6, K, phosphorus, magnesium, iron, zinc, copper, potassium, fiber, alcohol). Intakes sugars, C, caffeine, alcohol showed significant nonlinear associations Additionally, Single well may mitigate Moderately increasing specific maintaining balance be key strategies prevent

Language: Английский

Citations

6
Chronic alcohol consumption accelerates cardiovascular aging and decreases cardiovascular reserve capacity DOI Creative Commons
Partha Mukhopadhyay,

Burhan Yokus,

Bruno Paes‐Leme

et al.

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Abstract The pathology of cardiovascular aging is complex, involving mitochondrial dysfunction, oxidative and nitrative stress, DNA injury, impaired lipid metabolism, cell death, senescence, chronic inflammation. These processes lead to remodeling structural changes in the system, resulting a progressive decline reserve capacity health, an increased risk diseases mortality. Excessive alcohol consumption exacerbates these risks by promoting hypertension, stroke, arrhythmias, coronary artery disease, cardiomyopathy, sudden cardiac yet effects on remain unclear. Herein, we explored impact 6-month 5% Lieber-DeCarli diet young (3 months old) (24–26 Fisher F344BNF1 rats. We assessed detailed hemodynamics, function, oxidative/nitrative inflammation, myocardial fibrosis using pressure–volume isolated vascular rings, various histological, biochemical, molecular biology methods. Alcohol both rats disrupted cholesterol triglyceride leading systolic contractile function. In rats, further exacerbated diastolic dysfunction fibrosis. also apoptosis, senescence vasculature, contributing endothelial total peripheral resistance. Additionally, aging-related ventriculo-arterial uncoupling diminished efficiency, reducing capacity. conclusion, promotes diminishes already associated with aging.

Language: Английский

Citations

0
Objective Assessments of Smoking and Drinking Outperform Clinical Phenotypes in Predicting Variance in Epigenetic Aging DOI Open Access
Robert A. Philibert, Man‐Kit Lei, Mei Ling Ong

et al.

Genes, Journal Year: 2024, Volume and Issue: 15(7), P. 869 - 869

Published: July 2, 2024

The reliability of the associations acceleration epigenetic aging (EA) indices with clinical phenotypes other than for smoking and drinking is poorly understood. Furthermore, majority phenotyping studies have been conducted using data from subjects European ancestry. In order to address these limitations, we clinical, physiologic, assessments a cohort 278 middle-aged African American adults analyzed recently described principal-components-trained version GrimAge (i.e., PC-GrimAge) DunedinPACE (PACE) index regression analyses. We found that 74% PC-GrimAge accelerated could be predicted by simple baseline model consisting age, sex, methylation-sensitive digital PCR (MSdPCR) drinking. addition serological, demographic, medical history variables or PACE values did not meaningfully improve prediction, although some significantly fit. contrast, mapping cardiometabolic syndrome independently contribute prediction beyond model. were correlated (r = 0.2), little overlap in variance explained conveyed results suggest EA may differ information they provide significant limitations as screening tools guide patient care.

Language: Английский

Citations

3
Discovering the direct relations between nutrients and epigenetic ageing DOI Creative Commons
Pol Grootswagers,

Daimy Bach,

Ynte Biemans

et al.

The journal of nutrition health & aging, Journal Year: 2024, Volume and Issue: 28(9), P. 100324 - 100324

Published: July 26, 2024

Along with the ageing of society, absolute prevalence age-related diseases is expected to rise, leading a substantial burden on healthcare systems and society. Thus, there an urgent need promote healthy ageing. As opposed chronological age, biological age was introduced accurately represent process, as it considers physiological deterioration that linked morbidity mortality risk. Furthermore, responds various factors, including nutritional which have potential mitigate risk diseases. result, promising biomarker known epigenetic clock has emerged suitable measure investigate direct relations between factors ageing, thereby identifying intervention targets improve In this study, we analysed data from 3,969 postmenopausal women Women's Health Initiative identify nutrients are associated rate by using accurate called PhenoAge clock. We used Copula Graphical Models, data-driven exploratory analysis tool, relationships nutrient intake age-acceleration, while correcting for every variable in dataset. revealed increased dietary intakes coumestrol, beta-carotene arachidic acid were decelerated contrast, added sugar, gondoic acid, behenic arachidonic vitamin A ash accelerated women. Our study discovered revealing areas follow-up studies determine magnitude causality our estimated diet-epigenetic relationships.

Language: Английский

Citations

1
Parental Alcohol Exposures Associate with Lasting Mitochondrial Dysfunction and Accelerated Aging in a Mouse Model DOI Creative Commons
Alison Basel, Sanat S. Bhadsavle,

Katherine Z. Scaturro

et al.

Aging and Disease, Journal Year: 2024, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2024

Although detrimental changes in mitochondrial morphology and function are widely described symptoms of fetal alcohol exposure, no studies have followed these deficits into adult life or determined if they predispose individuals with spectrum disorders (FASDs) to accelerated biological aging. Here, we used a multiplex preclinical mouse model compare markers cellular senescence age-related outcomes induced by maternal, paternal, dual-parental exposures. We find that even middle (postnatal day 300), the offspring alcohol-exposed parents exhibited significant increases stress-induced premature brain liver, including an upregulation cell cycle inhibitory proteins increased senescence-associated β-galactosidase activity. Strikingly, male offspring, observe interaction between maternal paternal use, histological indicators liver disease exceeding those either use alone. Our indicate chronic parental causes enduring dysfunction resulting reduced NAD+/NAHD ratio altered expression NAD+-dependent deacetylases SIRT1 SIRT3. These observations suggest some aspects FASDs may be linked aging due programmed regulation bioenergetics.

Language: Английский

Citations

1
Reversing Aging and Improving Health Span in Glaucoma Patients: The Next Frontier? DOI Open Access

Tanuj Dada,

Karthikeyan Mahalingam,

Shibal Bhartiya

et al.

JOURNAL OF CURRENT GLAUCOMA PRACTICE, Journal Year: 2024, Volume and Issue: 18(3), P. 87 - 93

Published: Oct. 29, 2024

Dada T, Mahalingam K, Bhartiya S. Reversing Aging and Improving Health Span in Glaucoma Patients: The Next Frontier? J Curr Pract 2024;18(3):87-93.

Language: Английский

Citations

0
Association of DNA methylation age acceleration with digital clock drawing test performance: the Framingham Heart Study DOI Creative Commons

Zexu Li,

Huitong Ding, Mengyao Wang

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 7, 2024

Abstract Background Cognitive function measured by digital clock drawing test (dCDT) has drawn attention for their precision, automation, and reproductivity. However, the relationship between cognitive metrics biological aging is lacking. Methods We conducted association analyses dCDT quantified five DNA methylation (DNAm) age (Horvath, Hannum, GrimAge, PhenoAge, DunedinPACE) in Framingham Heart Study (FHS). linear regression to investigate functions (global four sub-domain functions) DNAm acceleration, adjusting covariates. used a false discovery rate (FDR) < 0.05 significance. Results Among 1,798 FHS participants (mean 65±13, 53% women), we found that lower total score associated with acceleration. Larger magnitudes of associations were observed older (≥ 65 years). The showed strongest DundinPACE pooled sample (beta = −2.1, FDR 0.0004), younger −1.9, 0.02), group −2.2, 0.01). was significantly acceleration estimated Horvath (beta=-1.9, =0.01) PhenoAge (beta=-2.5, FDR=0.01) while not or (<65 In functions, simple motor DunedinPACE (FDR 0.005) both groups GrimAge group), indicating deterioration various organ systems may particularly impact this domain. Discussion Our findings suggest middle-aged FHS, potentially shedding light on epigenetic mechanisms underlying digitally function.

Language: Английский

Citations

0