Dysfunction of motor cortices in Parkinson’s disease
Cerebral Cortex,
Journal Year:
2024,
Volume and Issue:
34(7)
Published: July 1, 2024
Abstract
The
cerebral
cortex
has
long
been
thought
to
be
involved
in
the
pathophysiology
of
motor
symptoms
Parkinson’s
disease.
impaired
cortical
function
is
believed
a
direct
and
immediate
effect
pathologically
patterned
basal
ganglia
output,
mediated
by
way
ventral
thalamus.
However,
recent
studies
humans
with
disease
animal
models
have
provided
strong
evidence
suggesting
that
involvement
much
broader
than
merely
serving
as
passive
conduit
for
subcortical
disturbances.
In
present
review,
we
discuss
disease–related
changes
frontal
regions,
focusing
on
neuropathology,
plasticity,
neurotransmission,
altered
network
interactions.
We
will
also
examine
exploring
circuits
potential
targets
neuromodulation
treat
Language: Английский
Waking up to the role of sleep disturbances in freezing of gait among people with Parkinson’s disease
Jennifer Zitser,
No information about this author
Talia Herman,
No information about this author
Nir Giladi
No information about this author
et al.
Parkinsonism & Related Disorders,
Journal Year:
2025,
Volume and Issue:
unknown, P. 107342 - 107342
Published: Feb. 1, 2025
Language: Английский
Cholinergic Basal Forebrain Integrity and Cognition in Parkinson's Disease: A Reappraisal of Magnetic Resonance Imaging Evidence
Movement Disorders,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 3, 2024
Abstract
Cognitive
impairment
is
a
well‐recognized
and
debilitating
symptom
of
Parkinson's
disease
(PD).
Degradation
in
the
cortical
cholinergic
system
thought
to
be
key
contributor.
Both
postmortem
vivo
positron
emission
tomography
(PET)
studies
have
provided
valuable
evidence
changes
PD,
which
are
pronounced
PD
dementia
(PDD).
A
growing
body
literature
has
employed
magnetic
resonance
imaging
(MRI),
noninvasive,
more
cost‐effective
alternative
PET,
examine
structural
PD.
This
review
provides
comprehensive
discussion
methodologies
findings
that
focused
on
relationship
between
basal
forebrain
(cBF)
integrity,
based
T1‐
diffusion‐weighted
MRI,
cognitive
function
Nucleus
basalis
Meynert
(Ch4)
volume
been
consistently
reduced
cognitively
impaired
samples
shown
potential
utility
as
prognostic
indicator
for
future
decline.
However,
extent
Ch4,
especially
early
stages
decline
remains
unclear.
In
addition,
change
anterior
cBF
regions
not
well
established.
underscores
importance
continued
cross‐sectional
longitudinal
research
elucidate
role
dysfunction
manifestations
©
2024
The
Author(s).
Movement
Disorders
published
by
Wiley
Periodicals
LLC
behalf
International
Parkinson
Disorder
Society.
Language: Английский
Regional Cerebral Cholinergic Vesicular Transporter Correlates of Visual Contrast Sensitivity in Parkinson’s Disease: Implications for Visual and Cognitive Function
Taylor Brown,
No information about this author
Prabesh Kanel,
No information about this author
Alexis Griggs
No information about this author
et al.
Parkinsonism & Related Disorders,
Journal Year:
2024,
Volume and Issue:
131, P. 107229 - 107229
Published: Dec. 9, 2024
Language: Английский
Multimodal gradients of basal forebrain connectivity across the neocortex
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Oct. 18, 2024
Cortical
cholinergic
projections
originate
from
subregions
of
the
basal
forebrain
(BF).
To
examine
its
organization
in
humans,
we
computed
multimodal
gradients
BF
connectivity
by
combining
7
T
diffusion
and
resting
state
functional
MRI.
Moving
anteromedial
to
posterolateral
BF,
observe
reduced
tethering
between
structural
gradients,
with
lowest
nucleus
basalis
Meynert.
In
neocortex,
this
gradient
is
expressed
progressively
unimodal
sensory
transmodal
cortex,
midcingulo-insular
network,
also
spatially
correlated
molecular
concentration
VAChT,
measured
[
Language: Английский