Spatial transcriptomics: a new frontier in accurate localization of breast cancer diagnosis and treatment DOI Creative Commons
Yang Zhang,

Shuhua Gong,

Xiaofei Liu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 8, 2024

Breast cancer is one of the most prevalent cancers in women globally. Its treatment and prognosis are significantly influenced by tumor microenvironment heterogeneity. Precision therapy enhances efficacy, reduces unwanted side effects, maximizes patients’ survival duration while improving their quality life. Spatial transcriptomics significant importance for precise breast cancer, playing a critical role revealing internal structural differences tumors composition microenvironment. It offers novel perspective studying spatial structure cell interactions within tumors, facilitating more effective personalized treatments cancer. This article will summarize latest findings diagnosis from transcriptomics, focusing on revelation microenvironment, identification new therapeutic targets, enhancement disease diagnostic accuracy, comprehension progression metastasis, assessment drug responses, creation high-resolution maps cells, representation heterogeneity, support clinical decision-making, particularly elucidating immunotherapy correlation with outcomes.

Language: Английский

Spatial transcriptomics: a new frontier in accurate localization of breast cancer diagnosis and treatment DOI Creative Commons
Yang Zhang,

Shuhua Gong,

Xiaofei Liu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 8, 2024

Breast cancer is one of the most prevalent cancers in women globally. Its treatment and prognosis are significantly influenced by tumor microenvironment heterogeneity. Precision therapy enhances efficacy, reduces unwanted side effects, maximizes patients’ survival duration while improving their quality life. Spatial transcriptomics significant importance for precise breast cancer, playing a critical role revealing internal structural differences tumors composition microenvironment. It offers novel perspective studying spatial structure cell interactions within tumors, facilitating more effective personalized treatments cancer. This article will summarize latest findings diagnosis from transcriptomics, focusing on revelation microenvironment, identification new therapeutic targets, enhancement disease diagnostic accuracy, comprehension progression metastasis, assessment drug responses, creation high-resolution maps cells, representation heterogeneity, support clinical decision-making, particularly elucidating immunotherapy correlation with outcomes.

Language: Английский

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