Antioxidant-Rich Functional Foods and Exercise: Unlocking Metabolic Health Through Nrf2 and Related Pathways

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1098 - 1098

Published: Jan. 27, 2025

This article reviews the synergistic effects of antioxidant-enriched functional foods and exercise in improving metabolic health, focusing on underlying molecular mechanisms. The review incorporates evidence from PubMed, SCOPUS, Web Science, PsycINFO, reference lists relevant up to 20 December 2024, highlighting central role Nrf2 pathway. As a critical regulator oxidative stress adaptation, mediates benefits these interventions. presents an innovative approach understanding regulation inflammation, its potential prevention treatment various diseases, including cancer, neurodegenerative disorders, cardiovascular pulmonary diabetes, inflammatory conditions, ageing, infections such as COVID-19. novelty this study is investigate bioactive compounds found (such polyphenols, flavonoids, vitamins) exercise-induced activation combined reveals their improve insulin sensitivity lipid metabolism reduce offering promising strategy for management chronic diseases. However, there are significant gaps current research, particularly regarding mechanisms interaction between diet, physical activity, activation, well long-term different populations, those with In addition, interactions other signalling pathways, AMPK, NF-κB, PI3K/Akt, collective contributions health explored. Furthermore, novel biomarkers presented assess impact strategies, NAD+/NADH ratio, GSH markers mitochondrial health. findings provide valuable insights into how integration antioxidant-rich diet regular can by activating related pathways represent strategies disorders. Further studies needed fully understand therapeutic interventions diseases stress, disease, cancer.

Language: Английский

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Oxidative Stress and Antioxidant Biomarkers in Clinical and Experimental Models of Non-Alcoholic Fatty Liver Disease

Medicina, Journal Year: 2019, Volume and Issue: 55(2), P. 26 - 26

Published: Jan. 24, 2019

Non-alcoholic fatty liver disease (NAFLD) is a term that covers range of hepatic disorders involving fat deposits in the liver. NAFLD begins with simple steatosis and progresses into non-alcoholic steatohepatitis (NASH) characterised by inflammation, fibrosis, apoptosis, oxidative stress, lipid peroxidation, mitochondrial dysfunction release adipokines pro-inflammatory cytokines. Oxidative stress antioxidants are known to play vital role pathogenesis severity NAFLD/NASH. A number antioxidant markers employed assessment pathological state progression disease. In this article, we review several biomarkers have been measured at clinical experimental levels. Also included comprehensive description sources contribution

Language: Английский

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Physical Exercise in the Oldest Old

Comprehensive physiology, Journal Year: 2019, Volume and Issue: unknown, P. 1281 - 1304

Published: Sept. 19, 2019

Societies are progressively aging, with the oldest old (i.e., those aged >80–85 years) being most rapidly expanding population segment. However, advanced aging comes at a price, as it is associated an increased incidence of so-called age-related conditions, including greater risk for loss functional independence. How to combat sarcopenia, frailty, and overall intrinsic capacity decline in elderly major challenge modern medicine, exercise appears be potential solution. In this article, we first summarize physiological mechanisms underlying deterioration capacity, particularly regarding phenotypes related decline. The main methods available physical assessment then described, finally multisystem benefits that (or "exercise mimetics" situations which volitional not feasible) can provide segment reviewed. summary, lifetime help attenuate many properties affected by especially when latter accompanied inactive lifestyle also obtained frail individuals who start exercising age. Multicomponent programs combining mainly aerobic resistance training should included old, during disuse such hospitalization. evidence still needed support effectiveness passive strategies neuromuscular electrical stimulation or vibration prevention disuse-induced negative adaptations people unable do exercise. © 2019 American Physiological Society. Compr Physiol 9:1281-1304, 2019.

Language: Английский

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Unveiling the Role of Inflammation and Oxidative Stress on Age-Related Cardiovascular Diseases

Oxidative Medicine and Cellular Longevity, Journal Year: 2020, Volume and Issue: 2020, P. 1 - 20

Published: May 9, 2020

The global population above 60 years has been growing exponentially in the last decades, which is accompanied by an increase prevalence of age-related chronic diseases, highlighting cardiovascular diseases (CVDs), such as hypertension, atherosclerosis, and heart failure. Aging main risk factor for these diseases. Such susceptibility to disease explained, at least part, oxidative stress, it damages cellular components proteins, DNA, lipids. In addition, inflammatory process aging “inflammaging” also contributes cell damage, creating a stressful environment drives development CVDs. Taken together, possible identify molecular connection between stress process, especially crosstalk transcription factors Nrf-2 NF- κ B are mediated redox signalling involved aging. Therapies that control this key targets prevention/combat review, we show basics inflammation including them, implications on

Language: Английский

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Role of increasing the aerobic capacity on improving the function of immune and respiratory systems in patients with coronavirus (COVID-19): A review

Diabetes & Metabolic Syndrome Clinical Research & Reviews, Journal Year: 2020, Volume and Issue: 14(4), P. 489 - 496

Published: April 28, 2020

Language: Английский

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