Negative emotional states and metabolic disorders in arterial hypertension in coal industry workers

Russian Journal of Occupational Health and Industrial Ecology, Journal Year: 2025, Volume and Issue: 65(1), P. 42 - 48

Published: Feb. 7, 2025

Introduction. Arterial hypertension, due to its prevalence and severity of complications, is one the leading causes disability working population. Psychosocial factors, including negative emotional states, are recognized as independent risk factors for development cardiovascular diseases. The relationship between states arterial hypertension in miners coal enterprises remains poorly understood. study aims consider metabolic disorders with mining workers. Materials methods. scientists examined 313 employees occupational diseases using questionnaires: DS14 determine psychological distress type D, Spielberger-Khanin establish level personal situational anxiety N.I. Vlakh questionnaire subdepression. diagnosis was established accordance clinical recommendations "Arterial adults". Results. incidence among surveyed 30.9%. authors found patients stage 1 an increase frequency overweight 80% (p<0.01; RR=2.57; CI=1.24–5.35) 87.9% (p<0.001; RR=3.99; CI=1.88–8.45), fasting hyperglycemia up 53.4% HR=2.67; CI=1.7–4.18), triglyceride levels 63.6% (p<0.005; RR=2.16; CI=1.32–3.54) 2nd 3rd stages. had no significant differences compared those normal blood pressure figures. Among stages, observed 40.8%, D — 58.9%, subdepression 32.4% 23.1%. reliability group stages has not been established. Limitations. limited a sample who were treated at Clinic Scientific Research Institute Complex Problems Hygiene Occupational Diseases. Conclusions. revealed industry With 2 3, there overweight, hypertriglyceridemia. There tendency anxiety, subdepression, D. Ethics. conducted compliance Ethical Principles conducting medical research human participation Helsinki Declaration World Medical Association "Ethical subject" amended 2013.

Language: Английский

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Accurate assessment of nocturnal blood pressure fall in patients with type 2 diabetes mellitus and resistant hypertension

Experimental and Clinical Gastroenterology, Journal Year: 2025, Volume and Issue: 9, P. 126 - 134

Published: March 6, 2025

Language: Английский

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Obesity and the nervous system

Obesity and metabolism, Journal Year: 2024, Volume and Issue: 21(1), P. 68 - 78

Published: March 6, 2024

The article discusses certain aspects of the relationship between neurological diseases and metabolic disorders that are extremely relevant in connection with pandemic spread obesity. pathogenesis damage to nervous system (NS) is considered detail. influence main factors on development cerebrovascular (CVD), incl. neuroinflammation, changes hemostasis, etc. demonstrated. problem cognitive dysfunction against background obesity due formation atrophic processes brain structures highlighted. Modern possibilities evaluation modulation eating behavior stimulation using functional magnetic resonance imaging (fMRI) navigational rhythmic transcranial (rTMS) described. cerebrometabolic health presented as a continuum cerebral disturbances. mechanisms interaction two most important systems body allow us consider occur them an integral neuroendocrine alteration.

Language: Английский

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Diversity of hypertension in obesity

Russian Journal of Cardiology, Journal Year: 2023, Volume and Issue: 28(4), P. 5360 - 5360

Published: Feb. 8, 2023

Induced hypertension (HTN) is one of the HTN types, pathogenetic mecha­nisms which are well studied: its main cause lies in dysfunction visceral adipose tissue, leads to renin-angiotensin-aldosterone system activation, imbalance sympathetic and parasympathetic systems, renal involvement, then vascular endothelium and, fact, an increase blood pressure consolidation. However, within this form, some mechanisms can be distinguished that, obesity, play a special role. This review describes such additional as chronic inflammation, excessive salt intake, dys­biosis, environmental factors. Understanding these features obesity has es­sential for achieving target levels. In addition, pays attention forms masked nocturnal, timely diagnosis extremely important initiation therapy improving prognosis.

Language: Английский

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Features of the course and treatment of bronchial asthma combined with arterial hypertension: a review

Russian Medicine, Journal Year: 2024, Volume and Issue: 30(1), P. 67 - 76

Published: March 14, 2024

Bronchial asthma (BA) is a serious medical and social problem. Many patients with have various concomitant chronic diseases, among which the pathology of cardiovascular system occupies an important place. Most often, occurs arterial hypertension (AH). This concurrence can lead to mutual aggravation progression these diseases may negatively affect prognosis. Usually, difficulties appear when choosing most effective therapy for BA along hypertension. review aimed analyse available publications on problem combination A literature presents summary, examines data prevalence indicates risk factors development asthma. The coexistence more typical in older people. includes questions regarding pathophysiology this comorbidity. role impaired gas exchange hypoxia, endothelial dysfunction, participation nitric oxide obesity are highlighted. significance nonrespiratory lung function shown, inflammation features comorbid indicated, as well contribution numerous genes In literature, 330 common been identified that be involved molecular mechanisms study shows effect course, control quality life patients. addition, article modern approaches main groups drugs used treat diseases. To date, studies demonstrated structure comorbidity, influence pathologies. Coexistence increases severity clinical symptoms. aspects treatment need thorough assessment safety pharmacological has demonstrated.

Language: Английский

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Single-pill combination of indapamide and perindopril: potential of practical application

Russian Journal of Cardiology, Journal Year: 2024, Volume and Issue: 29(3), P. 5831 - 5831

Published: April 17, 2024

The effectiveness of blood pressure control can be increased with the use single-pill combinations. When choosing an agent, evidence its components should focused. selection criteria are not only direct effects reducing pressure, but also organ protection and impact on prognosis. Perindopril indapamide have many years experience in a wide range patients used same treatment hypertension young elder­ly patients, normal-weight obese people, as tools for primary prevention myocardial infarction stroke, way to prevent recurrent events. article provides data advantages perindopril indapamide, potential combination, pleiotropic protective properties this drug. We systematized results related studies reflected main conclusions. Attention is paid latest long-term effect therapy risk cardiovascular

Language: Английский

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Can a lipophilic statin improve the treatment of heart failure with preserved ejection fraction in patients with hypertension and obesity?

Kardiologiia, Journal Year: 2023, Volume and Issue: 63(10), P. 47 - 54

Published: Nov. 8, 2023

To evaluate the effect of pleiotropic (anti-inflammatory and antifibrotic) effects a lipophilic statin (atorvastatin) in treatment heart failure (HF) with preserved left ventricular (LV) ejection fraction (HFpEF)Material methods. This observational study included 80 patients HFpEF; 40 them received atorvastatin 20-80 mg/day addition to standard treatment. patient who refused or had intolerance drug only The follow-up period was 12 months 5 visits. At visits, general condition evaluated; electrocardiography echocardiography were performed at rest during dosed physical exercise (PE); anthropometry analyzed; office blood pressure (BP), rate (HR) parameters systolic diastolic LV function recorded.Among into study, women aged 60-70 years prevailed pronounced obesity (n=46; 57.5% class II-II obesity), severe arterial hypertension (AH) (n=65; 81.2% grade 3 hypertension), dyslipidemia, type 2 diabetes mellitus, chronic kidney disease. administration therapy associated regression HF symptoms increased PE tolerance; these more after 6 observation. Furthermore, 12-month follow-up, significant multidirectional changes global longitudinal strain noted; main group, indicating an improvement while control it decreased reflecting early, preclinical manifestations progression. A stress test combination cardiopulmonary 64 HFpEF enrollment follow-up. When load reached 50 W group months, increase tissue Doppler velocity revealed, specifically e' septal lateral. led decrease E / ratio no time-related noted. Similar also detected higher levels PE.Long-term use clinical HFpEF, provided preservation function, some both PE.

Language: Английский

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Features of the formation of menopausal metabolic syndrome in arterial hypertension

Meditsinskiy sovet = Medical Council, Journal Year: 2023, Volume and Issue: 23, P. 357 - 365

Published: Jan. 19, 2023

Introduction . The concept of staging cardiometabolic diseases (CMD) in the clustering metabolic syndrome (MS) components is closely related to insulin resistance (IR), which depends on status sex hormones and age. It assumed that formation menopausal MS starts perimenopause due changes functional state pituitary-ovarian axis. However, mechanisms explaining differences IR, especially during transition, have not been established. Aim To evaluate relationship markers a cohort women aged 35–59 years without carbohydrate metabolism disorders with different ovaries, depending presence arterial hypertension (AH) influence age-associated factors. Materials methods In 88 normoglycemic axis divided into 2 groups hypertension, following were determined: BMI, waist circumference (WC), levels blood pressure (BP), triglycerides (TG), HDL cholesterol, FSH estradiol, fasting glucose (FG), TyG index. SPSS (version 13) assessed ME (25–75%); intergroup according Mann-Whitney test; Correlation analysis Spearman partial correlation performed level effect Results largest range significant associations, independent age tandem it, was found only group patients hypertension: OT FG, increase at > 25 mU/l; lipid parameters among themselves FG; estradiol levels, all focusing cholesterol. Conclusions process AH, relationships traditional CMD index, reflects IR through metabolism, are partially influenced by indicators: duration AH postmenopause.

Language: Английский

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Comorbidity in patients with arterial hypertension in therapeutic practice

Russian Journal of Preventive Medicine, Journal Year: 2023, Volume and Issue: 26(8), P. 100 - 100

Published: Jan. 1, 2023

Language: Английский

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Выраженность и структура коморбидности при наличии артериальной гипертензии

Ateroscleroz, Journal Year: 2023, Volume and Issue: 19(3), P. 234 - 236

Published: Oct. 6, 2023

Введение. Течение и прогноз, а также лечебно-профилактические мероприятия при артериальной гипертензии (АГ) значительно осложняются наличием множественной сопутствующей патологии этом заболевании, что существенно влияет на стоимость лечения, прогноз качество жизни пациентов [1–4]. Описаны особенности течения, клинические проявления отдельные патогенетические звенья формировании коморбидности АГ с отдельными нозологическим формами [5–8], однако системный подход к данной проблеме не разработан. Структура у больных учетом возрастной гендерной принадлежности в полной мере изучена.

Language: Русский

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