Positive Psychological Factors Relate to Domain-Specific Cognition and Daily Functioning in Middle-Aged and Older Adults with HIV

AIDS and Behavior, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Abstract Understanding positive psychological factors (PPFs; internal strengths, socioemotional support) that promote optimal health outcomes among people with HIV (PWH) is increasingly important. 122 PWH and 98 without (PWoH) were included in multivariable regressions, testing interactions between status PPFs on 7 cognitive domains 2 daily functioning outcomes, controlling for depressive symptoms. Overall, higher strengths related to better learning memory, whereas support was processing speed psychomotor speed. had a stronger relationship verbal fluency than PWoH. associated fewer impairments; however, only PWoH showed functional declines support. may require greater accommodate an increased burden of comorbidities leading difficulties. Among PWH, bolstering improve cognition; particularly benefit functioning.

Language: Английский

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Glycation metabolites predict incident age-related comorbidities and mortality in older people with HIV

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Abstract Glycation is a class of modifications arising from non-enzymatic reactions reducing sugars with proteins, lipids, and/or DNA, generating advanced glycation end-products (AGEs). AGEs are linked to many age-related comorbidities. In response HIV-1 infection, activated T-cells and macrophages shift their predominate metabolism oxidative phosphorylation glycolysis. Increased glycolytic flux enhances AGE formation, which may increase this prospective, multicenter cohort study antiretroviral therapy treated people HIV, we explored predictive associations by baseline plasma concentrations corresponding detoxification metabolites, incident comorbidities mortality. included dicarbonyl sugars: 3-deoxyglucosone, glyoxal, methylglyoxal. Methylglyoxal-derived metabolites carboxyethyl-arginine, carboxyethyl-lysine, methylglyoxal hydroimidazolone-1. Detoxification reduced oxidized glutathione, the glyoxalase cycle products lactoyl-glutathione lactoyl-Lysine modified proteins. Plasma was collected at entry, in fasting state, assayed liquid chromatography-mass spectroscopy. Incident clinical outcomes diabetes, chronic kidney disease, hypertension, neurocognitive impairment, peripheral neuropathy, frailty, fractures, recurrent falls, all-cause Among 376 participants, higher derived predicted increased risks while 3-deoxyglucosone an risk neuropathy. By contrast, or lactoyl-glutathione, proteins lower These findings support growing experimental evidence potential mitigate declines interventions that reduce glutathione.

Language: Английский

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Mechanisms of immune aging in HIV

Clinical Science, Journal Year: 2022, Volume and Issue: 136(1), P. 61 - 80

Published: Jan. 1, 2022

Abstract Massive CD4+ T-cell depletion as well sustained immune activation and inflammation are hallmarks of Human Immunodeficiency Virus (HIV)-1 infection. In recent years, an emerging concept draws intriguing parallel between HIV-1 infection aging. Indeed, many the alterations that affect innate adaptive subsets in HIV-infected individuals reminiscent process aging, characteristic old age. These changes, which presumed cause is systemic established patients, likely participate immuno-incompetence described with HIV progression. With success antiretroviral therapy (ART), HIV-seropositive patients can now live for years despite chronic viral However, acquired immunodeficiency syndrome (AIDS)-related opportunistic infections have given way to diseases leading death since Therefore, comparison infected uninfected elderly goes beyond sole onset immunosenescence extends deterioration several physiological functions related light this observation, it interesting understand precise link aging figure out how best care people living (PLWH).

Language: Английский

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Long COVID as a Disease of Accelerated Biological Aging: An Opportunity to Translate Geroscience Interventions

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 99, P. 102400 - 102400

Published: June 28, 2024

Language: Английский

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Pilot Trial of a Transdiagnostic Cognitive Behavioral Therapy (CBT)-Based Group Intervention to Reduce Psychological Distress, Facilitate Positive Behavior Change, and Mitigate Inflammation in Older People with HIV

AIDS and Behavior, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Language: Английский

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“A Tricky Dance”: Ryan White Service Experiences Among American Indian/Alaska Native Two-Spirit and LGBTQ + People Living with HIV

AIDS and Behavior, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Language: Английский

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The heart of the matter: modeling HIV-associated cardiovascular comorbidities in nonhuman primate models

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: April 22, 2025

With the advent of antiretroviral therapy (ART) that effectively suppresses HIV replication, and reduced AIDS progression, clinical spectrum infection has dramatically changed. Currently, people living with (PLWH) who receive ART have a nearly normal prognostic survival, yet they still experience higher morbidity mortality than age-matched uninfected subjects. The risk death in PLWH is linked to persistence residual systemic inflammation T-cell activation. These factors contribute accelerated aging incidence HIV-associated non-AIDS conditions, thereby presenting new diagnostic therapeutic challenges. This shifting paradigm associates cardiovascular disease (CVD), such as stroke, acute myocardial infarction sudden cardiac death, stark contrast opportunistic infections. coronary several folds general population. Study United States (US) certificates listing shows deaths from CVD doubled between 1996 2006. will become an even more prominent comorbidity considering 50% US are over 50 years old, age frequently CVD, complications frequent urban African-Americans Hispanics, which disproportionately affected by HIV. Therefore, reducing overall these primary challenge management chronic infection. Not surprisingly, REPRIEVE trial showed substantial benefit statins PLWH, current guidelines include statin administration PLWH. Nonhuman primate (NHP) models for comorbidities associated currently available their use testing approaches aimed at countering effects hypercoagulability discussed. Their can be tremendous help understand etiology, pathophysiology, determinants poorly understood. Use NHP could dissecting relative contribution virus, behavioral factors, risk, having potential us establish strategic controlling HIV-related CVD.

Language: Английский

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Cytomegalovirus serostatus among people with HIV, characterizing the prevalence, risk factors, and association with immune recovery

HIV Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Abstract Introduction Cytomegalovirus (CMV) infection is common among people with HIV (PWH), and may be associated negative outcomes. We aimed to identify the seroprevalence of CMV between 01 January 1998 June 2022 PWH accessing care at Southern Alberta Clinic (SAC) risk factors. also assess impact seropositivity on CD4+ T‐cells CD4+/CD8+ ratio recovery who maintain viral suppression. Methods Poisson regression models robust variance estimated crude adjusted prevalence ratios 95% confidence intervals factors for seronegativity. Among maintaining suppression, trends in median T‐cell count were visualized, continuous time‐to‐event Cox proportional hazard hazards (aHR) cell ≥500 cells/mm 3 >1 10 years by serostatus. Results 3249 PWH, 2954 (91%) seropositive. seronegativity was younger ages, male sex, non‐Hispanic white race an education ≥12 years. While did not affect following suppression (aHR 1.15 [0.89–1.48]), it a greater likelihood normalization 2.38 [1.85–3.07]) follow‐up. Conclusions coinfection PWH. found that positivity while recovery, reduced recovery. This suggests association chronic infection‐mediated immune activation inflammation

Language: Английский

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Anti-HIV Drugs Cause Mitochondrial Dysfunction in Monocyte-Derived Macrophages

Antimicrobial Agents and Chemotherapy, Journal Year: 2022, Volume and Issue: 66(4)

Published: March 16, 2022

Combination antiretroviral therapy (cART) dramatically changed the face of HIV/AIDS pandemic, making it one most prominent medical breakthroughs past 3 decades. However, as life span persons living with HIV (PLWH) continues to approach that general population, same cannot be said regarding their quality life.

Language: Английский

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Epigenetic Aging Biomarkers Associated With Cognitive Impairment in Older African American Adults With Human Immunodeficiency Virus (HIV)

Clinical Infectious Diseases, Journal Year: 2021, Volume and Issue: 73(11), P. 1982 - 1991

Published: June 17, 2021

Abstract Background Accelerated epigenetic aging using DNA methylation (DNAm)-based biomarkers has been reported in people with human immunodeficiency virus (HIV, PWH), but limited data are available among African Americans (AA), women, and older PWH. Methods DNAm was measured Illumina EPIC Arrays for 107 (69 PWH 38 HIV-seronegative controls) AA adults ≥60 years New York City. Six DNAm-based of were estimated: (1) age acceleration (EAA), (2) extrinsic (EEAA), (3) intrinsic (IEAA), (4) GrimAge, (5) PhenoAge, (6) DNAm-estimated telomere length (DNAm-TL). The National Institutes Health (NIH) Toolbox Cognition Battery (domains: executive function, attention, working memory, processing speed, language) Montreal Cognitive Assessment (MoCA) administered. Participants assessed frailty by the Fried criteria. Results control groups did not differ sex, chronological age, or ethnicity. In total, 83% had a viral load <50 copies/mL, 94% recent CD4 ≥200 cells/µL. group higher EAA, EEAA, lower DNAm-TL compared to controls. IEAA different between groups. For PWH, there significant negative correlations memory PhenoAge attention. No associations detected. Conclusions Evidence observed aging. There no evidence independent cell type composition (IEAA) associated HIV, this measure decreased cognitive function

Language: Английский

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