No evidence of immune exhaustion after repeated SARS-CoV-2 vaccination in vulnerable and healthy populations DOI Creative Commons
Dawn M. E. Bowdish, Jenna M. Benoit, Jessica A. Breznik

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 27, 2024

Abstract Frequent SARS-CoV-2 vaccination in vulnerable populations has raised concerns that this may contribute to T cell exhaustion, which could negatively affect the quality of immune protection. Herein, we examined impact repeated on phenotypic and functional exhaustion frail older adults long-term care, individuals immunosuppressive drugs, healthy adults. Spike-specific CD4+ CD8+ levels did not decline any cohort following vaccination, nor expression markers spike-specific or total cells increase. production multiple cytokines (i.e. polyfunctionality) response spike protein vaccination. None cohorts displayed elevated terminally differentiated vaccinations. Thus, was associated with increased adults, immunosuppressed individuals,

Language: Английский

Three doses of Sars-CoV-2 mRNA vaccine in older adults result in similar antibody responses but reduced cellular cytokine responses relative to younger adults DOI Creative Commons
Geir Bredholt, Marianne Sævik,

Hanne Søyland

et al.

Vaccine X, Journal Year: 2024, Volume and Issue: 20, P. 100564 - 100564

Published: Sept. 25, 2024

Language: Английский

Citations

3
Impact of Immunosenescence on Vaccine Immune Responses and Countermeasures DOI Creative Commons
Li Chen,

Chengwei Shao,

Jingxin Li

et al.

Vaccines, Journal Year: 2024, Volume and Issue: 12(11), P. 1289 - 1289

Published: Nov. 19, 2024

The biological progression of aging encompasses complex physiological processes. As individuals grow older, their functions gradually decline, including compromised immune responses, leading to immunosenescence. Immunosenescence significantly elevates disease susceptibility and severity in older populations while concurrently compromising vaccine-induced responses. This comprehensive review aims elucidate the implications immunosenescence for immunity facilitate development optimized vaccination strategies geriatric populations, with specific focus on COVID-19, influenza, pneumococcal, herpes zoster, respiratory syncytial virus (RSV) vaccines. further elucidates relationship between immunity. presents a systematic evaluation intervention designed enhance vaccine responses encompassing adjuvant utilization, antigen doses, frequency modification, inflammatory response modulation, lifestyle interventions, physical activity nutritional modifications. These are explored potential improve current efficacy inform next-generation vaccines populations.

Language: Английский

Citations

3
Booster COVID-19 mRNA vaccination ameliorates impaired B-cell but not T-cell responses in older adults DOI Creative Commons
Kohei Kometani,

Takaaki Yorimitsu,

Norihide Jo

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 9, 2024

Age-associated differences in the effect of repetitive vaccination, particularly on memory T-cell and B-cell responses, remain unclear. While older adults (aged ≥65 years) exhibited enhanced IgG responses following COVID-19 mRNA booster they produced fewer spike-specific circulating follicular helper T cells-1 than younger adults. Similarly, cytotoxic CD8

Language: Английский

Citations

2
No evidence of immune exhaustion after repeated SARS-CoV-2 vaccination in vulnerable and healthy populations DOI Creative Commons
Dawn M. E. Bowdish, Jenna M. Benoit, Jessica A. Breznik

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 27, 2024

Abstract Frequent SARS-CoV-2 vaccination in vulnerable populations has raised concerns that this may contribute to T cell exhaustion, which could negatively affect the quality of immune protection. Herein, we examined impact repeated on phenotypic and functional exhaustion frail older adults long-term care, individuals immunosuppressive drugs, healthy adults. Spike-specific CD4+ CD8+ levels did not decline any cohort following vaccination, nor expression markers spike-specific or total cells increase. production multiple cytokines (i.e. polyfunctionality) response spike protein vaccination. None cohorts displayed elevated terminally differentiated vaccinations. Thus, was associated with increased adults, immunosuppressed individuals,

Language: Английский

Citations

0