Exosome-Integrated Hydrogels for Bone Tissue Engineering DOI Creative Commons

Hee Sook Hwang,

Chung‐Sung Lee

Gels, Journal Year: 2024, Volume and Issue: 10(12), P. 762 - 762

Published: Nov. 23, 2024

Exosome-integrated hydrogels represent a promising frontier in bone tissue engineering, leveraging the unique biological properties of exosomes to enhance regenerative capabilities hydrogels. Exosomes, as naturally occurring extracellular vesicles, carry diverse array bioactive molecules that play critical roles intercellular communication and regeneration. When combined with hydrogels, these can be spatiotemporally delivered target sites, offering controlled sustained release therapeutic agents. This review aims provide comprehensive overview recent advancements development, application exosome-integrated for highlighting their potential overcome current challenges Furthermore, explores mechanistic pathways by which embedded within facilitate repair, encompassing regulation inflammatory pathways, enhancement angiogenic processes, induction osteogenic differentiation. Finally, addresses existing challenges, such scalability, reproducibility, regulatory considerations, while also suggesting future directions research this rapidly evolving field. Thus, we hope contributes advancing development next-generation biomaterials synergistically integrate exosome hydrogel technologies, thereby enhancing efficacy

Language: Английский

The potential use of bacteria and their derivatives as delivery systems for nanoparticles in the treatment of cancer DOI
Shiva Ahmadishoar, Saba Saeed,

Morug Salih Mahdi

et al.

Journal of drug targeting, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 54

Published: April 5, 2025

Cancer is a leading cause of mortality and morbidity worldwide. Nanomaterials, unique optical, magnetic, electrical properties at the nanoscale (1-100 nm), have been engineered to improve drug capacity, bioavailability, specificity in cancer treatment. These advancements address toxicity lack selectivity conventional therapies, enabling precise targeting cells, tumor microenvironment, immune system. Among emerging approaches, bacterial treatment shows promise due its natural ability target diverse therapeutic mechanisms, which nanotechnology can further enhance. Bacteria-based delivery systems leverage bacteria's adaptability survival strategies within human body. Bacterial derivatives, such as ghosts (BGs), extracellular vesicles (BEVs), dietary toxins, are recognized effective biological nanomaterials capable carrying nanoparticles (NPs). attracted increasing attention for their potential targeted NP This study explores use various bacteria byproducts vehicles, highlighting treating different types cancer. By combining strengths therapy, these innovative approaches aim revolutionize with improved precision efficacy.

Language: Английский

Citations

0
Engineered lung cell targeting and SLC7A11 siRNA expressing bacterial extracellular vesicles impair the progression of none‐small cell lung cancer DOI Creative Commons

Xiaodan Wan,

Xueliang Zhou,

Jinlong Liu

et al.

Bioengineering & Translational Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Abstract Non‐small cell lung cancer (NSCLC) presents significant therapeutic challenges, often characterized by aggressive proliferation and metastasis. This study investigates the role of SLC7A11, a ferroptosis‐related gene, in NSCLC progression potential engineered bacterial extracellular vesicles (BEVs) expressing SLC7A11‐targeting siRNA as strategy. Using TCGA GEO databases, we identified that SLC7A11 was significantly upregulated tissues. Functional assays demonstrated knockdown lines (NCI‐H2122 NCI‐H647) via qPCR, Western blot, immunofluorescence resulted impaired proliferation, migration, invasion abilities. In vivo xenograft models further revealed inhibited tumor growth metastasis, corroborated histological analyses. To enhance targeted delivery siRNA, BEVs with targeting peptide, verifying their structure function through transmission electron microscopy (TEM) nanoparticle tracking analysis (NTA). toxicity assessments indicated safety for these bioengineered vesicles. Importantly, treatment BEVs‐LCTP‐siSLC7A11 not only tumorigenesis but also activated ferroptosis pathways, evidenced altered expression levels transferrin metastatic Our findings suggest promising approach to inhibit while activating ferroptosis, offering insights into novel strategies against cancer.

Language: Английский

Citations

0
Exosome-Integrated Hydrogels for Bone Tissue Engineering DOI Creative Commons

Hee Sook Hwang,

Chung‐Sung Lee

Gels, Journal Year: 2024, Volume and Issue: 10(12), P. 762 - 762

Published: Nov. 23, 2024

Exosome-integrated hydrogels represent a promising frontier in bone tissue engineering, leveraging the unique biological properties of exosomes to enhance regenerative capabilities hydrogels. Exosomes, as naturally occurring extracellular vesicles, carry diverse array bioactive molecules that play critical roles intercellular communication and regeneration. When combined with hydrogels, these can be spatiotemporally delivered target sites, offering controlled sustained release therapeutic agents. This review aims provide comprehensive overview recent advancements development, application exosome-integrated for highlighting their potential overcome current challenges Furthermore, explores mechanistic pathways by which embedded within facilitate repair, encompassing regulation inflammatory pathways, enhancement angiogenic processes, induction osteogenic differentiation. Finally, addresses existing challenges, such scalability, reproducibility, regulatory considerations, while also suggesting future directions research this rapidly evolving field. Thus, we hope contributes advancing development next-generation biomaterials synergistically integrate exosome hydrogel technologies, thereby enhancing efficacy

Language: Английский

Citations

1