Intradialytic Tolerance and Recovery Time in Different High-Efficiency Hemodialysis Modalities

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(2), P. 326 - 326

Published: Jan. 6, 2024

There are several forms of maintenance high-efficiency hemodialysis (HD), including hemodiafiltrations (HDF) in different technical modes and expanded HD, using dialyzers with medium cut-off membranes. The aim the study was to assess intradialytic tolerance length dialysis recovery time (DRT) these modalities. This is an exploratory, crossover HD patients low comorbidity no clinical indications for use who were exposed five intermittent dialyses random order: high-flux (S-HD), (HDx), pre-dilution HDF (PRE-HDF), mix-dilution (MIX-HDF) post-dilution (POST-HDF). Twenty-four sessions each method included analysis. Dialysis parameters, blood flow rate, fluid rate temperature, pharmacological treatment constant. Average total convection volume post-HDF, pre-HDF mix-HDF 25.6 (3.8), 61.5 (7.2) 47.1 (11.4) L, respectively. During all therapies, monitored similarity their hydration statuses bioimpedance spectroscopy, similar variability over systemic pressure cardiac output, while peripheral resistance impedance cardiography. lowest frequency adverse events observed during HDx. Delayed DRT shortest PRE-HDF. Patients also more likely report immediate receiving These differences did not reach statistical significance; however, results suggest that may depend on used. supports need taking into account patient preferences quality life individualizing therapy patients.

Language: Английский

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Angiotensin Converting Enzyme Inhibitors May Increase While Active Vitamin D May Decrease the Risk of Severe Pneumonia in SARS-CoV-2 Infected Patients with Chronic Kidney Disease on Maintenance Hemodialysis

Viruses, Journal Year: 2022, Volume and Issue: 14(3), P. 451 - 451

Published: Feb. 22, 2022

The group most at risk of death due to COVID-19 are patients on maintenance hemodialysis (HD). study aims describe the clinical course early phase SARS-CoV-2 infection and find predictors development severe pneumonia in this population. This is a case series HD nonvaccinated with stratified into mild according chest computed tomography (CT) total severity score (TSS) admission. Epidemiological, demographic, clinical, laboratory data were obtained from hospital records. 85 mean age 69.74 (13.19) years dialysis vintage 38 (14-84) months included. On admission, 29.14% had no symptoms, 70.59% reported fatigue followed by fever-44.71%, shortness breath-40.0%, cough-30.59%. 20% finger oxygen saturation less than 90%. In 28.81% patients, pulmonary parenchyma was involved least 25%. factors associated include fever, low arterial partial pressure oxygen, increased C-reactive protein ferritin serum levels, blood count lymphocytes as well chronic treatment angiotensin converting enzyme inhibitors; while active vitamin D pneumonia. conclusion, even though nearly one-third completely asymptomatic, remaining usually only single large percentage them extensive inflammatory changes diagnosis infection. We identified potential pneumonia, which might help individualize pharmacological improve outcomes.

Language: Английский

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What has vaccination against COVID-19 in CKD patients taught us?

Journal of Nephrology, Journal Year: 2023, Volume and Issue: 36(5), P. 1257 - 1266

Published: May 4, 2023

Language: Английский

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Hospitalization and mortality during the pandemic in chronic hemodialysis patients and the general population in Peru

Brazilian Journal of Nephrology, Journal Year: 2023, Volume and Issue: 45(4), P. 440 - 448

Published: May 15, 2023

Patients with chronic kidney disease have a higher risk of severe and mortality from COVID-19 than the general population.To compare hospitalization rates during pandemic among hemodialysis (HD) patients population in Lima (Peru).This retrospective cohort included an assessment database HD health service providers social insurance benefit networks Callao between 2019 2021. Hospitalization were obtained for every 1,000 individuals, variations percentages cases deaths calculated. These compared those data standardized by age sex.An average 3,937 evaluated each month. Of these, 4.8% had 64.97% mild cases. The per 19.5, 29.28, 36.7 2019, 2020, 2021, respectively. 5.9, 9.74, 11.49 When to population, peaks both coincided plateaus waves pandemic. rate was 12 times twice as high.HD population. Peaks hospitalizations first second

Language: Английский

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COVID-19 Infection and Response to Vaccination in Chronic Kidney Disease and Renal Transplantation: A Brief Presentation

Life, Journal Year: 2022, Volume and Issue: 12(9), P. 1358 - 1358

Published: Aug. 31, 2022

Chronic kidney disease (CKD) is associated with phenotypic and functional changes in the immune system, followed by detrimental clinical consequences, such as severe infections defective response to vaccination. Two years of pandemic, due acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have undoubtedly changed world; however, all efforts confront infection provide new generation vaccines tremendously improved our understanding mechanisms against after Humoral cellular responses vaccines, including mRNA are apparently affected CKD patients, elimination recent thymic emigrant naïve lymphocytes regulatory T-cells, together contraction T-cell repertoire homeostatic proliferation rate, which characterized patients responsible for impaired activation. Successful renal transplantation will restore some these changes, although several epigenetic irreversible even accelerated induction immunosuppression. Response vaccination definitely among both RT patients. In present review, we analyzed differences between healthy individuals depicted specific parameters, alterations predisposing this deficient response.

Language: Английский

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Intradialytic Tolerance and Recovery Time in Different High-Efficiency Hemodialysis Modalities

Published: Dec. 28, 2023

There are several forms of maintenance high-efficiency hemodialysis (HD) including hemodiafiltrations (HDF) in different technic modes and expanded HD using dialyzers with medium cut-off membranes. The aim the study was to assess intradialytic tolerance length dialysis recovery time (DRT) these modalities. This is an exploratory, cross-over patients low comorbidity no clinical indications for use HD, who were exposed five intermittent random order: high flux (S-HD), (HDx), pre-dilution HDF (PRE-HDF), mix-dilution (MIX-HDF) post-dilution (POST-HDF). 24 sessions each method included analysis. Dialysis parameters blood flow rate, fluid rate temperature, pharmacological treatment constant. Average total convection volume post-HDF, pre-HDF mix-HDF 25.6 (3.8), 61.5 (7.2) 47.1 (11.4) l, respectively. During all therapies, had similar hydration status monitored bioimpedance spectroscopy variability over systemic pressure, cardiac output, peripheral resistance impedance cardiography. lowest frequency adverse events observed during HDx. Delayed DRT shortest PRE-HDF. Patients also more likely report immediate while receiving These differences did not reach statistical significance, however results suggest that, may depend on used. support need taking into account patient preferences quality life individualizing efficiency therapy patients.

Language: Английский

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Analysis of Experiences in Preventing COVID-19 in Hemodialysis Centers of the North of Poland before the Era of Vaccination

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(2), P. 684 - 684

Published: Jan. 7, 2022

The appearance of very contagious SARS-CoV-2 variants and waning vaccine immunity may indicate the need to return using universal methods preventing spread COVID-19.We performed a multicenter retrospective cohort survey study describe used in dialysis units prevent control also association between these incidence COVID-19 among hemodialyzed (HD) patients before era vaccination. population included all maintenance HD (n = 1569) 14 Pomeranian Voivodeship.The group 352 (199 men, 153 female) were confirmed for COVID-19. absolute cumulative studied period was 22.4%. It varied widely by units, ranging from 9.4% 36.9%. Universal preventive applied units. Different additional implemented some stations with varying frequency (36-86%). In order quantify scale methods, we calculated summary prevention index (PI), i.e., one point method. Lower found centers applying isolation hospitalized due diseases requiring hospitalization (17.42% ± 6.89 vs. 26.54 6.34; p 0.028) higher medium-size (ANOVA F: 0.017). Significant inverse correlation PI demonstrated as well (r -0.759; 0.002).The number measures, lower risk infection patients. Among procedures is significant importance. measures proved be effective vaccination should continued, threat still exists.

Language: Английский

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Vaccination and COVID-19 in Polish Dialysis Patients: Results from the European Clinical Dialysis Database

Vaccines, Journal Year: 2022, Volume and Issue: 10(9), P. 1565 - 1565

Published: Sept. 19, 2022

Background: Patients with end-stage kidney disease undergoing hemodialysis are particularly vulnerable to severe COVID-19 as a result of older age and multimorbidities. Objectives: Data still limited there no published data on mortality in hemodialyzed patients Poland, particular when vaccines became available. We assessed the epidemiologic clinical laboratory-confirmed 2019, 2020, 2021, well vaccination rate 2021. Methods: Retrospectively collected from 73 Fresenius Nephrocare Poland centers one public unit were analyzed. Results: In was 96%. The unadjusted (number deaths divided by number patients) 2019 18.8%, while (after exclusion COVID-related deaths) 2020 20.8%, 2021 16.22%. prevalence cardiovascular almost identical (41.4% vs. 41.2%, respectively), figures increased slightly 44.1%. sudden cardiac higher than (19.6% 17.3%, respectively) consequently decreased (10.0%), strokes (6.2% 5.4%, 3.31% 2021), whereas due gastrointestinal tract diseases lower (2.5% 3.2%, 2.25% diabetes complications (0.5% 1.3%, 0.5% sepsis (5.1% 6.3%, 8.79% respiratory failure (1.2 1.6%, 2.83% pneumonia (1.4% 2.0%, 0.82%). There 1493 positive patients, among them, 191 died (12.79%). 1224 260 (21.24%). dialyzed contributed 13.39% 16.21% all recorded deaths. Conclusions: HD despite very high up non-COVID-19 may be possibility hospitalization dedicated care during pandemic. This information is extremely important order develop methods protect this highly patient group. Prevention plays key role; other measures essential mitigation spread centers.

Language: Английский

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Immunity after Vaccination against COVID-19

Vaccines, Journal Year: 2023, Volume and Issue: 11(11), P. 1723 - 1723

Published: Nov. 17, 2023

The outbreak of the COVID-19 pandemic at turn 2019 and 2020 posed a substantial challenge for world [...]

Language: Английский

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Intradialytic Tolerance and Recovery Time in Different High-Efficiency Hemodialysis Modalities

Published: Nov. 30, 2023

There are several forms of maintenance high-efficiency hemodialysis (HD) including hemodiafiltrations (HDF) in different technic modes and expanded HD using dialyzers with medium cut-off membranes. The aim the study was to assess intradialytic tolerance length dialysis recovery time (DRT) these modalities. This is an exploratory, cross-over patients low comorbidity no clinical indications for use HD, who were exposed five intermittent random order: high flux (S-HD), (HDx), pre-dilution HDF (PRE-HDF), mix-dilution (MIX-HDF) post-dilution (POST-HDF). 24 sessions each method included analysis. Dialysis parameters blood flow rate, fluid rate temperature, pharmacological treatment constant. Average total convection volume post-HDF, pre-HDF mix-HDF 25.6 (3.8), 61.5 (7.2) 47.1 (11.4) l, respectively. During all therapies, had similar hydration status monitored bioimpedance spectroscopy variability over systemic pressure, cardiac output, peripheral resistance impedance cardiography. lowest frequency adverse events observed during HDx. Delayed DRT shortest PRE-HDF. Patients also more likely report immediate while receiving These differences did not reach statistical significance, however results suggest that, may depend on used. support need taking into account patient preferences quality life individualizing efficiency therapy patients.

Language: Английский

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