Pentraxin 3 as a Noninvasive Biomarker of Fibrosis and Carotid Intima-media Thickness in Patients with Metabolic Associated Fatty Liver Disease
Gene Expression,
Journal Year:
2024,
Volume and Issue:
000(000), P. 000 - 000
Published: May 29, 2024
Background
and
objectivesMetabolic-associated
fatty
liver
disease
(MAFLD)
may
increase
the
risk
of
cardiovascular
events.
In
this
study,
we
assessed
predictive
value
pentraxin
3
(PTX3)
for
severe
fibrosis
carotid
intima-media
thickness
(CIMT)
in
patients
with
MAFLD.
Language: Английский
The prognostic role of aspartate transaminase to platelet ratio index on outcomes after nonemergent major hepatectomy
Surgery,
Journal Year:
2024,
Volume and Issue:
176(3), P. 763 - 768
Published: July 9, 2024
Language: Английский
Diagnostic Thresholds and Clinical Value of Ultrasound-Derived Fat Fraction in Assessing Hepatic Steatosis: Insights from a Prospective Study
Yimin Wu,
No information about this author
Lifang Fan,
No information about this author
Jiang Cheng
No information about this author
et al.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 4, 2024
Abstract
Background
A
reliable
assessment
of
hepatic
steatosis
is
imperative
for
the
effective
management
metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD).
This
study
assesses
effectiveness
ultrasound-derived
fat
fraction
(UDFF)
in
measuring
and
determines
diagnostic
thresholds
different
severity
levels.
Methods
prospective
cross-sectional
involved
79
participants
(mean
age
42.8
±
13.8
years)
recruited
from
two
centers.
MRI
proton
density
(PDFF)
served
as
reference
standard
assessing
steatosis.
Pearson
correlation
coefficients
were
applied
to
determine
relationship
between
UDFF
MRI-PDFF,
while
Bland-Altman
analysis
evaluated
measurement
consistency
PDFF.ROC
curve
performance
against
visual
score,
Fatty
Liver
Index
(FLI),
CAP
score
(CAPS),
Hepatic
Steatosis
(HSI).
Results
The
showed
a
strong
with
MRI-PDFF
(r
=
0.84,
p
<
0.001),
mean
bias
2.06%
95%
limits
agreement
ranging
−
7.03–11.15%.
AUC
values
diagnosing
grades
≥
S1,
≥S2,
S3
0.95,
0.97,
0.94,
respectively,
outperforming
FLI,
CAPS,
HSI.
optimal
cutoff
these
8.5%,
16.5%,
22%.
Conclusion
shows
high
PDFF
grades,
although
tend
be
slightly
higher
than
those
PDFF.
Language: Английский
Ultrasound evaluation of chronic liver disease
Abdominal Radiology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 18, 2024
Language: Английский