Differential encoding of mammalian proprioception by voltage-gated sodium channels
Science Advances,
Journal Year:
2025,
Volume and Issue:
11(2)
Published: Jan. 8, 2025
Animals
requiring
purposeful
movement
for
survival
are
endowed
with
mechanoreceptors,
called
proprioceptors,
that
provide
essential
sensory
feedback
from
muscles
and
joints
to
spinal
cord
circuits,
which
modulates
motor
output.
Despite
the
nature
of
proprioceptive
signaling
in
daily
life,
mechanisms
governing
proprioceptor
activity
poorly
understood.
Here,
we
identified
nonredundant
roles
two
voltage-gated
sodium
channels
(Na
V
s),
Na
1.1
1.6,
mammalian
proprioception.
Deletion
1.6
somatosensory
neurons
cKO
mice)
causes
severe
deficits
accompanied
by
loss
transmission,
contrasts
our
previous
findings
using
similar
mouse
models
target
).
In
animals,
observed
impairments
end-organ
structure
a
marked
reduction
skeletal
muscle
myofiber
size
were
absent
mice.
We
attribute
differential
contributions
distinct
cellular
localization
patterns.
Collectively,
evidence
s
uniquely
shape
neural
within
modality.
Language: Английский
Physiological Resilience: What Is It and How Might It Be Trained?
Scandinavian Journal of Medicine and Science in Sports,
Journal Year:
2025,
Volume and Issue:
35(3)
Published: March 1, 2025
Physiological
resilience
has
recently
been
recognized
as
an
additional
factor
that
influences
endurance
exercise
performance.
It
thus
incorporated
into
a
modified,
contemporary
version
of
"the
Joyner
model"
which
acknowledges
start-line
values
V̇O2max,
efficiency
or
economy,
and
metabolic
thresholds
are
prone
to
deterioration,
often
with
appreciable
interindividual
variability,
during
prolonged
exercise.
The
physiological
underpinnings
elusive
sports
physiologists
presently
concerned
developing
practical
testing
protocols
reflect
athlete's
characteristics.
is
also
important
consider
why
some
athletes
more
resilient
than
others
whether
can
be
enhanced-and,
if
so,
training
programs
specific
sessions
might
stimulate
its
development.
While
data
scant,
the
available
evidence
suggests
consistency
accumulation
relatively
large
volumes
over
longer-term
(i.e.,
several
years)
promote
resilience.
inclusion
regular
within
program,
especially
when
these
include
bouts
high-intensity
at
race
pace
above
progressive
increase
in
intensity
face
fatigue,
represent
effective
means
enhancing
Finally,
resistance
training,
heavy
strength
plyometric
appears
have
positive
effects
on
Considerations
for
resilience,
alongside
other
established
determinants
performance,
will
likely
long-term
development
successful
athletes.
Language: Английский
Exercise-driven cellular autophagy: A bridge to systematic wellness
Journal of Advanced Research,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Exercise
enhances
health
by
supporting
homeostasis,
bolstering
defenses,
and
aiding
disease
recovery.
It
activates
autophagy,
a
conserved
cellular
process
essential
for
maintaining
balance,
while
dysregulated
autophagy
contributes
to
progression.
Despite
extensive
research
on
exercise
independently,
their
interplay
remains
insufficiently
understood.
This
review
explores
the
molecular
mechanisms
of
exercise-induced
in
various
tissues,
focusing
key
transduction
pathways.
examines
how
different
types
trigger
specific
autophagic
responses,
balance
addressing
systemic
dysfunctions.
The
also
highlights
signaling
pathways
involved,
roles
protecting
organ
function,
reducing
risk,
promoting
longevity,
offering
clear
understanding
link
between
autophagy.
Exercise-induced
is
governed
highly
coordinated
dynamic
integrating
direct
indirect
mechanical
forces
biochemical
signals,
linking
physical
activity
across
multiple
systems.
Its
activation
influenced
modality,
intensity,
duration,
individual
biological
characteristics,
including
age,
sex,
muscle
fiber
composition.
Aerobic
exercises
primarily
engage
AMPK
mTOR
pathways,
mitochondrial
quality
homeostasis.
Anaerobic
training
PI3K/Akt
signaling,
modulating
molecules
like
FOXO3a
Beclin1
drive
repair.
In
pathological
contexts,
proteostasis,
tissue
regeneration,
benefiting
conditions
sarcopenia,
neurodegeneration,
myocardial
ischemia,
metabolic
disorders,
cancer.
However,
excessive
may
lead
overactivation,
leading
atrophy
or
cardiac
remodeling.
underscores
critical
need
balanced
regimens
maximize
therapeutic
efficacy
minimizing
risks.
Future
should
prioritize
identifying
reliable
biomarkers,
optimizing
protocols,
with
pharmacological
strategies
enhance
outcomes.
Language: Английский
The role of irisin in exercise-induced muscle and metabolic health: a narrative review
Sumaya Nadhim Mohammed,
No information about this author
Mohannad Hamid Jasim,
No information about this author
Shahad Hisham Mahmood
No information about this author
et al.
Naunyn-Schmiedeberg s Archives of Pharmacology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 1, 2025
Language: Английский
Testing Green Tea Extract and Ammonium Salts as Stimulants of Physical Performance in a Forced Swimming Rat Experimental Model
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(19), P. 10438 - 10438
Published: Sept. 27, 2024
The
study
of
drugs
natural
origin
that
increase
endurance
and/or
accelerate
recovery
is
an
integral
part
sports
medicine
and
physiology.
In
this
paper,
decaffeinated
green
tea
extract
(GTE)
two
ammonium
salts-chloride
(ACL)
carbonate
(ACR)-were
tested
individually
in
combination
with
GTE
as
stimulants
physical
performance
a
forced
swimming
rat
experimental
model.
determined
parameters
can
be
divided
into
seven
blocks:
functional
(swimming
duration);
biochemistry
blood
plasma;
erythrocytes;
hematology;
immunology;
gene
expression
slow-
fast-twitch
muscles
(m.
soleus,
SOL,
m.
extensor
digitorum
longus,
EDL,
respectively);
morphometric
indicators
muscles.
Regarding
the
negative
control
(intact
animals),
maximum
number
changes
all
blocks
was
recorded
+
ACR
group,
whose
animals
showed
result
minimum
lactate
values
on
last
day
experiment.
Next,
terms
changes,
were
groups
ACR,
ACL,
NaCl
(positive
control).
general,
identified
adaptive
proportional
to
state
corresponding
groups,
duration
load
four
days
However,
not
only
total
but
also
qualitative
composition
interest.
results
comparative
analysis
suggest
that,
model
we
developed,
promotes
restoration
body
moderate
mobilization
immune
system,
while
small
doses
salts,
especially
carbonate,
contribute
performance,
which
associated
satisfactory
skeletal
entire
body.
combined
use
salts
does
give
clearly
positive
effect.
Language: Английский
Differential encoding of mammalian proprioception by voltage-gated sodium channels
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 28, 2024
Abstract
Animals
that
require
purposeful
movement
for
survival
are
endowed
with
mechanosensory
neurons
called
proprioceptors
provide
essential
sensory
feedback
from
muscles
and
joints
to
spinal
cord
circuits,
which
modulates
motor
output.
Despite
the
nature
of
proprioceptive
signaling
in
daily
life,
mechanisms
governing
proprioceptor
activity
poorly
understood.
Here,
we
have
identified
distinct
nonredundant
roles
two
voltage-gated
sodium
channels
(NaVs),
NaV1.1
NaV1.6,
mammalian
proprioception.
Deletion
NaV1.6
somatosensory
(NaV1.6
cKO
mice)
causes
severe
deficits
accompanied
by
complete
loss
transmission,
contrasts
our
previous
findings
using
similar
mouse
models
target
(NaV1.1
).
In
animals,
caused
non-cell-
autonomous
impairments
end-organs
skeletal
muscle
were
absent
mice.
We
attribute
differential
contribution
function
cellular
localization
patterns.
Collectively,
these
data
first
evidence
NaV
subtypes
uniquely
shape
neurotransmission
within
a
modality.
Teaser
Voltage
gated
differentially
encode
proprioception
via
Language: Английский